A Role of GABA Analogues in the Treatment of Neurological Diseases

K.      Gajcy; S.      Lochynski; T.      Librowski

doi:10.2174/092986710791698549

Abstract

γ-Amino butyric acid is an extremely important inhibitory neurotransmitter in the mammalian central nervous system and is essential for the overall balance between neuronal excitation and inhibition. It is well documented that GABA deficiency is associated with several important neurological disorders such as Huntingtons chorea, Parkinsons and Alzheimers disease and other psychiatric disorders, like anxiety, depression, pain, panic, or mania. Although, it is known that increasing the brain concentration of GABA prevents convulsions, the high polarity and flexible structure of this compound are probably responsible for its inefficiency as an anticonvulsant when administered orally or intravenously. To resolve this problem, GABA analogues are being designed. Over recent years, there has been increasing interest in the synthesis and pharmacological effect of new GABA derivatives, which can be considered as potent drugs in the treatment of neurodegenerative disorders.

Keywords: GABA analogues, neurological diseases, GABAergic receptors, cyclopropane derivatives

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