Abstract
This narrative review outlines the work done in other fields with regards biomarker validation and qualification and the lessons that we may learn from this experience. Defining a universally agreed upon path for biomarker validation and qualification is urgently needed to circumvent many of the hurdles faced in OA therapeutic development irrespective of whether we are discussing biochemical markers, imaging markers or other measures. This review proposes a path that may be suitable for osteoarthritis and poses some logical next steps that will take us in this direction.
Keywords: Osteoarthritis, biomarkers, imaging, biochemical marker, validation, qualification, intervention, surrogate
Current Drug Targets
Title: A Pathway and Approach to Biomarker Validation and Qualification for Osteoarthritis Clinical Trials
Volume: 11 Issue: 5
Author(s): David J. Hunter, Elena Losina, Ali Guermazi, Deb Burstein, Marissa N. Lassere and Virginia Kraus
Affiliation:
Keywords: Osteoarthritis, biomarkers, imaging, biochemical marker, validation, qualification, intervention, surrogate
Abstract: This narrative review outlines the work done in other fields with regards biomarker validation and qualification and the lessons that we may learn from this experience. Defining a universally agreed upon path for biomarker validation and qualification is urgently needed to circumvent many of the hurdles faced in OA therapeutic development irrespective of whether we are discussing biochemical markers, imaging markers or other measures. This review proposes a path that may be suitable for osteoarthritis and poses some logical next steps that will take us in this direction.
Export Options
About this article
Cite this article as:
J. Hunter David, Losina Elena, Guermazi Ali, Burstein Deb, N. Lassere Marissa and Kraus Virginia, A Pathway and Approach to Biomarker Validation and Qualification for Osteoarthritis Clinical Trials, Current Drug Targets 2010; 11 (5) . https://dx.doi.org/10.2174/138945010791011947
DOI https://dx.doi.org/10.2174/138945010791011947 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Related Journals
Related Books
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Rheumatoid Foot and Ankle Surgery
Current Rheumatology Reviews Integrating Autism Spectrum Disorder Pathophysiology: Mitochondria, Vitamin A, CD38, Oxytocin, Serotonin and Melatonergic Alterations in the Placenta and Gut
Current Pharmaceutical Design Hydrogen Sulfide-Based Therapies: Focus on H2S Releasing NSAIDs
Inflammation & Allergy - Drug Targets (Discontinued) Glia: An Important Target for Anti-Inflammatory and Antidepressant Activity
Current Drug Targets Meet Our Editorial Board Member
Current Neuropharmacology The Role of Amitriptyline in the Management of Non-small Cell Lung Cancer
Current Cancer Therapy Reviews Leptinaemia and Antiendothelial Antibodies in Accelerated Atherosclerosis – Is There a Relationship?
Vascular Disease Prevention (Discontinued) Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes
Current Neuropharmacology The Impact of Thrombopoietin on Clinical Practice
Current Pharmaceutical Design Subject Index To Volume 12
Current Pharmaceutical Design Meet Our Editorial Board Member
Mini-Reviews in Medicinal Chemistry Editorial [Hot Topic: New Avenues of Research on Multiple Sclerosis from the Perspective of Chronic Cerebrospinal Venous Insufficiency Paradigm (Guest Editor: Marian Simka)]
Reviews on Recent Clinical Trials α-Secretase in Alzheimers Disease and Beyond: Mechanistic, Regulation and Function in the Shedding of Membrane Proteins
Current Alzheimer Research Prospective Clinical Applications of CRF Peptide Antagonists
Current Molecular Pharmacology Therapeutics Targeting Nogo-A Hold Promise for Stroke Restoration
CNS & Neurological Disorders - Drug Targets Inflammation in Peripheral Arterial Disease (PAD)
Current Pharmaceutical Design GPRASP/ARMCX Protein Family: Potential Involvement in Health and Diseases Revealed by their Novel Interacting Partners
Current Topics in Medicinal Chemistry Exploring the Role of Aggregated Proteomes in the Pathogenesis of Alzheimer’s Disease
Current Protein & Peptide Science Opioids in Neuropathic Pain
Current Pharmaceutical Design Impact of Aging on the Angiogenic Potential of the Myocardium: Implications for Angiogenic Therapies with Emphasis on Sirtuin Agonists
Recent Patents on Cardiovascular Drug Discovery