Abstract
To achieve therapeutic effects, gene transportation or gene transfection becomes the key technique of gene therapy. Since viral vectors for gene therapy have shown serious problems, including immunogenicity and other adverse effects, non-viral carriers have attracted a great deal of attention, despite the fact that the transfection efficiencies are lower than those by viral carriers. Therefore, the major challenge of gene delivery is to improve the transfection efficiencies of the non-viral carriers, and first of all, the cell penetration efficiencies. This review focuses on recent approaches in the development of new non-viral gene delivery vectors, with great respect to those constructed based on cell penetration pathways of intracellular process considering transfection efficiency and cell penetration efficiency. Further development of sophisticated delivery systems is prospected for the non-viral vectors application in gene therapy.
Keywords: Gene delivery, Transfection efficiency, Pharmaceutical strategies, Non-viral vector, Cell penetration pathways
Current Gene Therapy
Title: Pharmaceutical Strategies Enhancing Cell Penetration Efficiencies of Non-Viral Gene Delivery Systems
Volume: 9 Issue: 4
Author(s): Chunxi Liu and Na Zhang
Affiliation:
Keywords: Gene delivery, Transfection efficiency, Pharmaceutical strategies, Non-viral vector, Cell penetration pathways
Abstract: To achieve therapeutic effects, gene transportation or gene transfection becomes the key technique of gene therapy. Since viral vectors for gene therapy have shown serious problems, including immunogenicity and other adverse effects, non-viral carriers have attracted a great deal of attention, despite the fact that the transfection efficiencies are lower than those by viral carriers. Therefore, the major challenge of gene delivery is to improve the transfection efficiencies of the non-viral carriers, and first of all, the cell penetration efficiencies. This review focuses on recent approaches in the development of new non-viral gene delivery vectors, with great respect to those constructed based on cell penetration pathways of intracellular process considering transfection efficiency and cell penetration efficiency. Further development of sophisticated delivery systems is prospected for the non-viral vectors application in gene therapy.
Export Options
About this article
Cite this article as:
Liu Chunxi and Zhang Na, Pharmaceutical Strategies Enhancing Cell Penetration Efficiencies of Non-Viral Gene Delivery Systems, Current Gene Therapy 2009; 9 (4) . https://dx.doi.org/10.2174/156652309788921053
DOI https://dx.doi.org/10.2174/156652309788921053 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
Call for Papers in Thematic Issues
Programmed Cell Death Genes in Oncology: Pioneering Therapeutic and Diagnostic Frontiers (BMS-CGT-2024-HT-45)
Programmed Cell Death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Medicinal Compound Celastrol As a Potential Clinical Anticancer Drug: Lessons Learned From Preclinical Studies
Clinical Cancer Drugs MicroRNA-208a Potentiates Angiotensin II-triggered Cardiac Myoblasts Apoptosis via Inhibiting Nemo-like Kinase (NLK)
Current Pharmaceutical Design Interactions Between Cholinergic and Fibroblast Growth Factor Receptors in Brain Trophism and Plasticity
Current Protein & Peptide Science Ligands Targeting the Excitatory Amino Acid Transporters (EAATs)
Current Topics in Medicinal Chemistry Synthetic Small Molecule Inhibitors of Hh Signaling As Anti-Cancer Chemotherapeutics
Current Medicinal Chemistry Chromatin Remodeling Agents for Cancer Therapy
Reviews on Recent Clinical Trials Nucleic Acid Aptamers Against Protein Kinases
Current Medicinal Chemistry Effects of Plants and Isolates of Celastraceae Family on Cancer Pathways
Anti-Cancer Agents in Medicinal Chemistry Glycogen Metabolism and Brain Pathologies
Central Nervous System Agents in Medicinal Chemistry Rho GTPase Effector Functions in Tumor Cell Invasion and Metastasis
Current Drug Targets Angiopoietin-2 Axis Inhibitors: Current Status and Future Considerations for Cancer Therapy
Current Angiogenesis (Discontinued) Vector Delivery Methods and Targeting Strategies for Gene Therapy of Brain Tumors
Current Gene Therapy On the Epistemological Crisis in Genomics
Current Genomics MiR-125b Inhibits Cell Proliferation and Induces Apoptosis in Human Colon Cancer SW480 Cells <i>via</i> Targeting STAT3
Recent Patents on Anti-Cancer Drug Discovery Natural Products and Cancer Stem Cells
Current Pharmaceutical Design Anticancer Alkylphospholipids: Mechanisms of Action, Cellular Sensitivity and Resistance, and Clinical Prospects
Current Pharmaceutical Design Killing Glioma ‘Stem-like’ Cells via Drug-Induced Relocation of Endosomal Urokinase Proteins
Anti-Cancer Agents in Medicinal Chemistry <sup>68</sup>Ga-labeled HBED-CC Variant of uPAR Targeting Peptide AE105 Compared with <sup>68</sup>Ga-NODAGA-AE105
Anti-Cancer Agents in Medicinal Chemistry Immunologic Diseases and Brain Tumors
Inflammation & Allergy - Drug Targets (Discontinued) Dihydromyricetin Reduces TGF-β Via P53 Activation-dependent Mechanism in Hepatocellular Carcinoma HepG2 Cells
Protein & Peptide Letters