Abstract
Proper control of cell cycle progression requires the functionality of a small family of activating phosphatases termed Cdc25, which have been implicated in cancer and Alzheimers disease. These protein tyrosine phosphatases are therefore recognized as attractive molecular targets for small molecules. We review the rationale, approaches, progress and challenges for developing small molecule inhibitors of the Cdc25 family. A number of potential chemical probes are discussed and their characteristics are summarized.
Keywords: Protein tyrosine phosphatase, natural products, enzyme assays, reactive oxygen species
Anti-Cancer Agents in Medicinal Chemistry
Title: Is Cdc25 a Druggable Target?
Volume: 8 Issue: 8
Author(s): John S. Lazo and Peter Wipf
Affiliation:
Keywords: Protein tyrosine phosphatase, natural products, enzyme assays, reactive oxygen species
Abstract: Proper control of cell cycle progression requires the functionality of a small family of activating phosphatases termed Cdc25, which have been implicated in cancer and Alzheimers disease. These protein tyrosine phosphatases are therefore recognized as attractive molecular targets for small molecules. We review the rationale, approaches, progress and challenges for developing small molecule inhibitors of the Cdc25 family. A number of potential chemical probes are discussed and their characteristics are summarized.
Export Options
About this article
Cite this article as:
Lazo S. John and Wipf Peter, Is Cdc25 a Druggable Target?, Anti-Cancer Agents in Medicinal Chemistry 2008; 8 (8) . https://dx.doi.org/10.2174/187152008786847738
DOI https://dx.doi.org/10.2174/187152008786847738 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Structural MRI Biomarkers of Mild Cognitive Impairment from Young Elders to Centenarians
Current Alzheimer Research Metabolism of Antiarrhythmics
Current Drug Metabolism The Use of Tripeptides for Lead Discovery of 5-HT4 Receptor Ligands
Protein & Peptide Letters A Qualitative Report on the Subjective Experience of Intravenous Psilocybin Administered in an fMRI Environment
Current Drug Abuse Reviews Synthesis of 2,5-Disubstituted-1,3,4-oxadiazole Analogs as Novel Anticancer and Antimicrobial Agents
Letters in Drug Design & Discovery Psychosocial Factors and Central Sensitivity Syndromes
Current Rheumatology Reviews Current Neuropharmacological Interventions in Autism: Potential Drug Targets from Pre-clinical and Clinical Findings
Current Psychopharmacology Cellular Changes, Molecular Pathways and the Immune System Following Photodynamic Treatment
Current Medicinal Chemistry Endothelial Dysfunction and Coronary Artery Spasm
Current Drug Targets - Cardiovascular & Hematological Disorders Pure Emotion-loaded Materials in the International Affective Digitized Sounds (IADS): A Study on Intensity Ratings in Chinese University Students
Current Psychiatry Research and Reviews Acute Administration of Nigella sativa Showed Anxiolytic and Anti- Depression Effects in Rats
Current Nutrition & Food Science Nanostructured Modulators of Neuroglia
Current Pharmaceutical Design Ghrelin and Cardiovascular Diseases
Current Cardiology Reviews Metabolomics
Current Drug Metabolism Interaction of Human Alpha-2-Macroglobulin with Pesticide Aldicarb Using Spectroscopy and Molecular Docking
Protein & Peptide Letters Recent Developments in Potential Anxiolytic Agents Targeting GABAA/BzR Complex or the Translocator Protein (18kDa) (TSPO)
Current Topics in Medicinal Chemistry LC-MS/MS Profiling of 37 Fingerprint Phytochemicals in <i>Oenanthe fistulosa</i> L. and its Biological Activities
The Natural Products Journal The Potential Role of Pro-Inflammatory and Anti-Inflammatory Cytokines in Epilepsy Pathogenesis
Endocrine, Metabolic & Immune Disorders - Drug Targets Management of Tuberculosis in Children and New Treatment Options
Infectious Disorders - Drug Targets COMMENTARY: Magnetic Resonance Techniques Applied to Parkinson’s Disease
CNS & Neurological Disorders - Drug Targets