Targeting RSK: An Overview of Small Molecule Inhibitors

Title: Targeting RSK: An Overview of Small Molecule Inhibitors

Volume: 8 Issue: 7

Author(s): Tam Luong Nguyen

Affiliation:

Keywords: Serine/threonine kinase, inhibitor, RSK specific

Abstract: Ribosomal S6 kinase (RSK) is a family of serine/threonine kinases that has been identified as a promising anti-cancer target. While a number of protein kinase inhibitors that have potent activity against other serine/threonine kinases were shown to also inactivate RSK, there is keen interest in the three different inhibitor chemotypes that were shown to be RSK specific, since these compounds have tremendous utility as chemical probes in elucidating the biochemistry of the RSK signaling cascade and unraveling the molecular basis of cancer. Because each compound may have therapeutic potential, the nonspecific kinase inhibitors as well as the RSK specific inhibitors will be discussed.

Cite this article as:

Nguyen Luong Tam, Targeting RSK: An Overview of Small Molecule Inhibitors, Anti-Cancer Agents in Medicinal Chemistry 2008; 8 (7) . https://dx.doi.org/10.2174/187152008785914770