Abstract
The TGF-β signaling pathway plays a significant role in various biological phenomena such as cell growth, embryogenesis, differentiation, morphogenesis and apoptosis. Gastrointestinal endodermal stem cells, influenced by TGF- β signals, undergo asymmetric cell division that leads to differentiation into tissue-specific functional cells such as hepatocytes and gut epithelial cells. Disruption of this process results in tissue-specific cancer development. This review illustrates the role of TGF-β signaling in normal and cancer stem cells. Through mouse studies targeting different members of this pathway, investigators will be able to better define mechanisms of malignant progression in order to develop and improve cancer therapeutics.
Keywords: TGF-β, ELF, Smad4, gastrointestinal tract, cancer stem cells
Current Cancer Therapy Reviews
Title: TGF-β Signaling in Gastrointestinal Cancer Stem Cells
Volume: 4 Issue: 3
Author(s): Chohee Yun, Jonathan Mendelson, Young Woo Kim and Lopa Mishra
Affiliation:
Keywords: TGF-β, ELF, Smad4, gastrointestinal tract, cancer stem cells
Abstract: The TGF-β signaling pathway plays a significant role in various biological phenomena such as cell growth, embryogenesis, differentiation, morphogenesis and apoptosis. Gastrointestinal endodermal stem cells, influenced by TGF- β signals, undergo asymmetric cell division that leads to differentiation into tissue-specific functional cells such as hepatocytes and gut epithelial cells. Disruption of this process results in tissue-specific cancer development. This review illustrates the role of TGF-β signaling in normal and cancer stem cells. Through mouse studies targeting different members of this pathway, investigators will be able to better define mechanisms of malignant progression in order to develop and improve cancer therapeutics.
Export Options
About this article
Cite this article as:
Yun Chohee, Mendelson Jonathan, Kim Woo Young and Mishra Lopa, TGF-β Signaling in Gastrointestinal Cancer Stem Cells, Current Cancer Therapy Reviews 2008; 4 (3) . https://dx.doi.org/10.2174/157339408785294339
DOI https://dx.doi.org/10.2174/157339408785294339 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Pharmacological Inhibitors of Fatty Acid Synthase (FASN)-Catalyzed Endogenous Fatty Acid Biogenesis: A New Family of Anti-Cancer Agents?
Current Pharmaceutical Biotechnology Application of Monoclonal Antibodies as Cancer Therapy in Solid Tumors
Current Clinical Pharmacology Invertebrate FMRFamide Related Peptides
Protein & Peptide Letters Potential of DNMT and its Epigenetic Regulation for Lung Cancer Therapy
Current Genomics New Potential Pharmaceutical Applications of Hypericum Species
Mini-Reviews in Medicinal Chemistry Recent Progress in the Pharmacology of Imidazo[1,2-a]pyridines
Mini-Reviews in Medicinal Chemistry Bamboo a Supplement to Human Health: A Comprehensive Review on its Ethnopharmacology, Phytochemistry, and Pharmacological Activity
The Natural Products Journal Role of ABC Transporters in Veterinary Drug Research and Parasite Resistance
Current Drug Delivery <i>Circular RNA NF1-419</i> Inhibits Proliferation and Induces Apoptosis by Regulating Lipid Metabolism in Astroglioma Cells
Recent Patents on Anti-Cancer Drug Discovery A Comprehensive Review on Recent Developments in the Field of Biological Applications of Potent Pyrazolines Derived from Chalcone Precursors
Letters in Drug Design & Discovery Pharmacokinetic and Pharmacogenetic Markers of Irinotecan Toxicity
Current Medicinal Chemistry Meta-analysis Reveals No Association of DNMT3B -149 C>T Gene Polymorphism With Overall Cancer Risk
Current Genomics Digestive Enzyme Supplementation in Gastrointestinal Diseases
Current Drug Metabolism Challenges in the Management of Paediatric Febrile Neutropenia
Current Pediatric Reviews HIF-1 Signaling in Drug Resistance to Chemotherapy
Current Medicinal Chemistry Shear-Wave and Strain Elastography: A Comparative Review on Principles, Basic Techniques and Applications.
Current Medical Imaging Preface:
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Antitumor Carbazoles
Anti-Cancer Agents in Medicinal Chemistry Epidemiology, Clinical Presentation and Treatment of Mucosal Melanoma
Clinical Cancer Drugs Recent Advances in Receptor-Targeted Fluorescent Probes for In Vivo Cancer Imaging
Current Medicinal Chemistry