Abstract
Chloride channels are involved in many different physiological processes such as cell migration, proliferation and apoptosis. The importance of the CLC family of chloride channels in these cellular functions has been recognized only recently. Infiltration of inflammatory cells, such as eosinophils, T cells, mast cells and neutrophils, is a hallmark of allergy and asthma. Indeed, chronic asthma is associated with widespread damage to the bronchial epithelium, due to excessive apoptosis, and with defective epithelial repair. However, the relationship between the immune cells of allergic airway diseases and chloride channels has not been clearly elucidated. In this review, characteristics of CLC channels are mainly discussed based on their function and presence in different immune cells in airway diseases. Not only are chloride channels involved in the recruitment of immune cells, they also play a role in the activation of these cells. Thus, understanding the role of CLC channels in the immune cells would provide unique insights to the pathophysiologic process of chronic asthma and the means to prevent or reverse the disease.
Keywords: Apoptosis, cell migration, cell proliferation, chloride channels, eosinophils, epithelial cells, macrophages, mast cells, neutrophils, T lymphocytes
Current Molecular Medicine
Title: Chloride Channel Expression and Functional Diversity in the Immune Cells of Allergic Diseases
Volume: 8 Issue: 5
Author(s): Gang Cheng, Ajeeth Ramanathan, Zhifei Shao and Devendra K. Agrawal
Affiliation:
Keywords: Apoptosis, cell migration, cell proliferation, chloride channels, eosinophils, epithelial cells, macrophages, mast cells, neutrophils, T lymphocytes
Abstract: Chloride channels are involved in many different physiological processes such as cell migration, proliferation and apoptosis. The importance of the CLC family of chloride channels in these cellular functions has been recognized only recently. Infiltration of inflammatory cells, such as eosinophils, T cells, mast cells and neutrophils, is a hallmark of allergy and asthma. Indeed, chronic asthma is associated with widespread damage to the bronchial epithelium, due to excessive apoptosis, and with defective epithelial repair. However, the relationship between the immune cells of allergic airway diseases and chloride channels has not been clearly elucidated. In this review, characteristics of CLC channels are mainly discussed based on their function and presence in different immune cells in airway diseases. Not only are chloride channels involved in the recruitment of immune cells, they also play a role in the activation of these cells. Thus, understanding the role of CLC channels in the immune cells would provide unique insights to the pathophysiologic process of chronic asthma and the means to prevent or reverse the disease.
Export Options
About this article
Cite this article as:
Cheng Gang, Ramanathan Ajeeth, Shao Zhifei and Agrawal K. Devendra, Chloride Channel Expression and Functional Diversity in the Immune Cells of Allergic Diseases, Current Molecular Medicine 2008; 8 (5) . https://dx.doi.org/10.2174/156652408785160934
DOI https://dx.doi.org/10.2174/156652408785160934 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Advances in Noninvasive Pulmonary Gene Therapy
Current Drug Delivery A Review of <i>Saurauia roxburghii</i> Wall. (Actinidiacaea) as a Traditional Medicinal Plant, Its Phytochemical Study and Therapeutic Potential
Mini-Reviews in Medicinal Chemistry Selective Inhibitors of Nuclear Factor of Activated T Cells: Potential Therapeutic Drugs for the Treatment of Immunological and Inflammatory Diseases
Inflammation & Allergy - Drug Targets (Discontinued) Therapeutic Potential of Janus Kinase 3 (JAK3) Inhibitors
Current Pharmaceutical Design Biochanin A Ameliorates Ovalbumin-induced Airway Inflammation through Peroxisome Proliferator-Activated Receptor-Gamma in a Mouse Model
Endocrine, Metabolic & Immune Disorders - Drug Targets The Airway Neurogenic Inflammation: Clinical and Pharmacological Implications
Inflammation & Allergy - Drug Targets (Discontinued) Use of Antibiotics in Bronchiectasis
Reviews on Recent Clinical Trials Clinical Implications of Recent Insights into the Structural Biology of Beta2 Adrenoceptors
Current Drug Targets Editorial [Hot Topic: Pediatricians Role in Tobacco Prevention and Control (Guest Editors: Norman Hymowitz, Dana Best and Joseph V. Schwab)]
Current Pediatric Reviews Compartmentalized and Internally Structured Particles for Drug Delivery - A Review
Current Pharmaceutical Design Editorial [Hot Topic: (Guest Editor: Allan R. Brasier)]
Current Proteomics Acne in the Adult
Mini-Reviews in Medicinal Chemistry Effects of Sublingual Immunotherapy on Allergic Inflammation: An Update
Inflammation & Allergy - Drug Targets (Discontinued) Advances and Patents about Grinding Equipments with Nano-Particle Jet Minimum Quantity Lubrication
Recent Patents on Nanotechnology Recent Advances in the Design and Synthesis of Prednisolone and Methylprednisolone Conjugates
Current Pharmaceutical Design Anti-Inflammatory Properties of Acetylcholinesterase Inhibitors Administred in Alzheimers Disease
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Redox-Active Selenium in Health and Disease: A Conceptual Review
Mini-Reviews in Medicinal Chemistry Inhaled Biologics: From Preclinical to Product Approval
Current Pharmaceutical Design Molecular and Biochemical Properties of Storage Mites (Except Blomia species)
Protein & Peptide Letters Medicinal Chemistry Approaches of Controlling Gastrointestinal Side Effects of Non-Steroidal Anti-Inflammatory Drugs. Endogenous Protective Mechanisms and Drug Design
Medicinal Chemistry