Myostatin in the Pathophysiology of Skeletal Muscle

Title: Myostatin in the Pathophysiology of Skeletal Muscle

Volume: 8 Issue: 7

Author(s): Anne Bonnieu, Gilles Carnac and Barbara Vernus

Affiliation:

Keywords: p38 MAPK, myostatin, satellite cells, extra-cellular matrix, muscle regeneration

Abstract: Myostatin is an endogenous, negative regulator of muscle growth determining both muscle fiber number and size. The myostatin pathway is conserved across diverse species ranging from zebrafish to humans. Experimental models of muscle growth and regeneration have implicated myostatin as an important mediator of catabolic pathways in muscle cells. Inhibition of this pathway has emerged as a promising therapy for muscle wasting. Here we discuss the recent developments and the controversies in myostatin research, focusing on the molecular and cellular mechanisms underlying the actions of myostatin on skeletal muscle and the potential therapeutic role of myostatin on muscle-related disorders.

Cite this article as:

Bonnieu Anne, Carnac Gilles and Vernus Barbara, Myostatin in the Pathophysiology of Skeletal Muscle, Current Genomics 2007; 8 (7) . https://dx.doi.org/10.2174/138920207783591672