Abstract
Arthropod-borne viruses (arboviruses) are a significant cause of human diseases worldwide. Interactions between these viruses and the innate immune system play a major role in determining the outcome of disease. The complement system is particularly important in this process as activation of complement can contribute to both host defense as well as injury to host tissues. This review focuses on the increasing evidence that the complement system plays key roles in both protective and pathologic outcomes of arbovirus infection.
Keywords: Arbovirus, viral pathogenesis, alphavirus, flavivirus, complement
Current Drug Targets
Title: The Host Complement System and Arbovirus Pathogenesis
Volume: 9 Issue: 2
Author(s): M. T. Heise and T. E. Morrison
Affiliation:
Keywords: Arbovirus, viral pathogenesis, alphavirus, flavivirus, complement
Abstract: Arthropod-borne viruses (arboviruses) are a significant cause of human diseases worldwide. Interactions between these viruses and the innate immune system play a major role in determining the outcome of disease. The complement system is particularly important in this process as activation of complement can contribute to both host defense as well as injury to host tissues. This review focuses on the increasing evidence that the complement system plays key roles in both protective and pathologic outcomes of arbovirus infection.
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Cite this article as:
Heise T. M. and Morrison E. T., The Host Complement System and Arbovirus Pathogenesis, Current Drug Targets 2008; 9 (2) . https://dx.doi.org/10.2174/138945008783502485
DOI https://dx.doi.org/10.2174/138945008783502485 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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