Abstract
It is now well accepted that colon cancer evolves from a multi-step process and is a disease strongly influenced by environmental factors, with diet being one of the most important modifying agents. Among dietary factors, there is cogent evidence indicating a protective effect of fish oil feeding with respect to colonic tumor development. We have recently demonstrated that the balance between colonic epithelial cell proliferation and programmed cell death (apoptosis) can be favorably modulated by feeding fish oil, containing n-3 polyunsaturated fatty acids, specifically, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). We propose that the suppression of colonic tumor development by dietary n-3 polyunsaturated fatty acids may be due to an effect on the subcellular localization of oncogenic p21 ras. The potential for fish oil feeding to antagonize ras-dependent signal transduction is significant because the acquisition of chronically activated ras via mutation or overexpression is a relatively early step in colorectal cancer development.
Current Organic Chemistry
Title: Dietary Fish Oil Reduces Colon Cancer Risk
Volume: 4 Issue: 11
Author(s): Esther D. Collett, Laurie A. Davidson, Joanne R. Lupton and Robert S. Chapkin
Affiliation:
Abstract: It is now well accepted that colon cancer evolves from a multi-step process and is a disease strongly influenced by environmental factors, with diet being one of the most important modifying agents. Among dietary factors, there is cogent evidence indicating a protective effect of fish oil feeding with respect to colonic tumor development. We have recently demonstrated that the balance between colonic epithelial cell proliferation and programmed cell death (apoptosis) can be favorably modulated by feeding fish oil, containing n-3 polyunsaturated fatty acids, specifically, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). We propose that the suppression of colonic tumor development by dietary n-3 polyunsaturated fatty acids may be due to an effect on the subcellular localization of oncogenic p21 ras. The potential for fish oil feeding to antagonize ras-dependent signal transduction is significant because the acquisition of chronically activated ras via mutation or overexpression is a relatively early step in colorectal cancer development.
Export Options
About this article
Cite this article as:
Collett D. Esther, Davidson A. Laurie, Lupton R. Joanne and Chapkin S. Robert, Dietary Fish Oil Reduces Colon Cancer Risk, Current Organic Chemistry 2000; 4 (11) . https://dx.doi.org/10.2174/1385272003375824
DOI https://dx.doi.org/10.2174/1385272003375824 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Diagnostic Utility of Pleural Fluid Tests in Clinical Practice
Current Respiratory Medicine Reviews Sirtuin-1 and HIV-1: An Overview
Current Drug Targets Hypoxia Inducible Factor-1 in Cancer Immune Suppression
Current Immunology Reviews (Discontinued) Cardiotoxicity of Molecularly Targeted Agents
Current Cardiology Reviews Epigenetic Mechanisms Underlying Diet-Sourced Compounds in the Prevention and Treatment of Gastrointestinal Cancer
Anti-Cancer Agents in Medicinal Chemistry Psychoimmunological Analysis of Cancer Patients: Correlation with the Prognosis
Current Aging Science Prospects of miRNA-Based Therapy for Pancreatic Cancer
Current Drug Targets The Roles of Sox Family Genes in Sarcoma
Current Drug Targets Basic Mechanisms Involved in the Anti-Cancer Effects of Melatonin
Current Medicinal Chemistry Ras-Induced Resistance to Lapatinib is Overcome by MEK Inhibition
Current Cancer Drug Targets Molecular Determinants of Gastrointestinal and Liver Cancers: Role of Bile Acid Activated Nuclear Receptors
Current Topics in Medicinal Chemistry Current Concepts and Future Directions in Radioimmunotherapy
Current Drug Discovery Technologies Iron Oxide Nanoparticles: An Insight into their Biomedical Applications
Current Medicinal Chemistry Mn-SOD and Chronic Inflammation of Gastric Mucosa
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Combining Angiogenesis Inhibitors with Radiation: Advances and Challenges in Cancer Treatment
Current Pharmaceutical Design The Changing Role of Radiation in the Post-TME ERA of Rectal Cancer
Current Cancer Therapy Reviews Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer
Current Neurovascular Research Biosynthetic and Metabolic Alterations in Cancer Growth
Current Angiogenesis (Discontinued) The Potential Clinical Value of Curcumin and its Derivatives in Colorectal Cancer
Anti-Cancer Agents in Medicinal Chemistry Anti-cancer Effects of a Neutral Triterpene Fraction from Ganoderma lucidum and its Active Constituents on SW620 Human Colorectal Cancer Cells
Anti-Cancer Agents in Medicinal Chemistry