Abstract
A search for susceptibility genes for psychiatric illness may benefit from recent advances in mouse molecular genetics. Molecular and phenotypic characterization of single gene mutations in mice with anomalies in neurophysiological or neurodevelopmental processes, disrupted in a psychiatric disease, can reveal new insights into the pathways that underlie these genetically complex illnesses. However, in the case of many psychiatric disorders such as autism and schizophrenia, the exact nature of these neurophysiological or neurodevelopmental processes is not known. For example, nothing is known about the molecular pathology underlying impaired social behavior, a prominent feature of both autism and schizophrenia. In this review we discuss published reports on genetic and pharmacological studies of social behavior in mice. We argue that paradigms for studies of the genetics and neurobiological origins of social interactions in mice are amenable to gene- and phenotype-based mutagenesis screens and that identification of a core set of genes that underlie social behavior in mice may provide important clues for our understanding of some aspects of autism and schizophrenia.
Keywords: endophenotype, psychiatric, neurodevelopmental, autism, schizophrenia
Current Genomics
Title: Social Behavior as an Endophenotype for Psychiatric Disorders Development of Mouse Models
Volume: 2 Issue: 1
Author(s): Dubravka Hranilovic and Maja Bucan
Affiliation:
Keywords: endophenotype, psychiatric, neurodevelopmental, autism, schizophrenia
Abstract: A search for susceptibility genes for psychiatric illness may benefit from recent advances in mouse molecular genetics. Molecular and phenotypic characterization of single gene mutations in mice with anomalies in neurophysiological or neurodevelopmental processes, disrupted in a psychiatric disease, can reveal new insights into the pathways that underlie these genetically complex illnesses. However, in the case of many psychiatric disorders such as autism and schizophrenia, the exact nature of these neurophysiological or neurodevelopmental processes is not known. For example, nothing is known about the molecular pathology underlying impaired social behavior, a prominent feature of both autism and schizophrenia. In this review we discuss published reports on genetic and pharmacological studies of social behavior in mice. We argue that paradigms for studies of the genetics and neurobiological origins of social interactions in mice are amenable to gene- and phenotype-based mutagenesis screens and that identification of a core set of genes that underlie social behavior in mice may provide important clues for our understanding of some aspects of autism and schizophrenia.
Export Options
About this article
Cite this article as:
Hranilovic Dubravka and Bucan Maja, Social Behavior as an Endophenotype for Psychiatric Disorders Development of Mouse Models, Current Genomics 2001; 2 (1) . https://dx.doi.org/10.2174/1389202013351138
DOI https://dx.doi.org/10.2174/1389202013351138 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Deep learning in Single Cell Analysis
The field of biology is undergoing a revolution in our ability to study individual cells at the molecular level, and to integrate data from multiple sources and modalities. This has been made possible by advances in technologies for single-cell sequencing, multi-omics profiling, spatial transcriptomics, and high-throughput imaging, as well as ...read more
New insights on Pediatric Tumors and Associated Cancer Predisposition Syndromes
Because of the broad spectrum of children cancer susceptibility, the diagnosis of cancer risk syndromes in children is rarely used in direct cancer treatment. The field of pediatric cancer genetics and genomics will only continue to expand as a result of increasing use of genetic testing tools. It's possible that ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Autism Spectrum Disorders: Etiology and Pharmacotherapy
Current Drug Therapy Regulators of Platelet cAMP Levels: Clinical and Therapeutic Implications
Current Medicinal Chemistry A Review of Pharmacokinetic Parameters of Metabolites and Prodrugs
Drug Metabolism Letters Nanoemulgel: A Promising Phase in Drug Delivery
Current Pharmaceutical Design Potential Therapeutic Application of Chondroitin Sulfate/Dermatan Sulfate
Current Drug Discovery Technologies Anticonvulsant and Antitubercular Activities of 6-Phenyl/Biphenyl-4-yl-2- [2-(pyridin-2-ylamino)-ethyl]- and 6-(Biphenyl-4yl)-2-(2N-subtituted amin- 1-yl)-ethyl derivatives of 4,5-dihydropyridazin-3(2H)-one
Letters in Drug Design & Discovery “Epileptic Encephalopathy” of Infancy and Childhood: Electro-Clinical Pictures and Recent Understandings
Current Neuropharmacology Pharmacological Manipulation of Neural Progenitor Pathways In Situ: Possibilities for Neural Restoration in the Injured Adult Brain
Current Medicinal Chemistry - Central Nervous System Agents Structure, Pharmacology and Therapeutic Prospects of Family C G-Protein Coupled Receptors
Current Drug Targets Pathophysiogenesis of Mesial Temporal Lobe Epilepsy: Is Prevention of Damage Antiepileptogenic?
Current Medicinal Chemistry The Molecular Targets of Cannabinoids in the Treatment of Cancer and Inflammation
Current Pharmaceutical Design The Relationship Between Cleft Lip, Maxillary Hypoplasia, Hypoxia and Phenytoin
Current Pharmaceutical Design Neuropharmacology of Vestibular System Disorders
Current Neuropharmacology Lepidium Sativum but not Nigella Sativa Affects Carbamazepine Disposition in an Animal Model
Drug Metabolism Letters Can Nutrition Play a Role as a Stimulant for COVID 19 in Children?
Reviews on Recent Clinical Trials Disorders of Consciousness and Electrophysiological Treatment Strategies: A Review of the Literature and New Perspectives
Current Pharmaceutical Design Transcriptional Dys-regulation in Anxiety and Major Depression: 5-HT1A Gene Promoter Architecture as a Therapeutic Opportunity
Current Pharmaceutical Design Neurotransmitter Effects in Human Immunodeficiency Virus (HIV) and Simian Immuno-Deficiency Virus (SIV) Infection
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Brain Serotonin, Psychoactive Drugs, and Effects on Reproduction
Central Nervous System Agents in Medicinal Chemistry Fluorescent Dyes for Bio-Applications in the Patent Literature
Recent Patents on Materials Science