Critical Role for IL-15 in Innate Immunity

Title: Critical Role for IL-15 in Innate Immunity

Volume: 2 Issue: 4

Author(s): Toshiaki Ohteki

Affiliation:

Keywords: il-15, il-2, innate immunity, iel, il-15/il-15r

Abstract: Although some functional activities of interleukin (IL)-15 on NK and T cells overlap with those of IL-2, recent findings obtained from gene-targeted mice deficient in components of IL-2 / IL-15 system demonstrate distinct roles of IL-15 for the activation of innate immune system. IL-15 is a pivotal cytokine for the development and survival of NK cells, NKT cells, TCRγδ+ intestinal intraepithelial lymphocytes (iIEL), and for the functional maturation of dendritic cells and macrophages. IL-15 is also important for memory T cell maintenance in vivo. In this review, I summarize recent progress of studies in the IL-15 / IL-15R system.

Cite this article as:

Ohteki Toshiaki, Critical Role for IL-15 in Innate Immunity, Current Molecular Medicine 2002; 2 (4) . https://dx.doi.org/10.2174/1566524023362519