Abstract
Direct visualization of the composition of the atherosclerotic plaque during its natural history and after therapeutic intervention may be helpful in detecting lesions with high risk of acute events and in understanding progression and regression of the disease. A wide variety of invasive and non-invasive imaging techniques is available to detect clue aspects of atherosclerosis from the early stage to the clinical evidence appearance. We will firstly review the ongoing technological and clinical research on both invasive and noninvasive techniques. Afterward, we will discuss in detail the use of high-resolution, multicontrast magnetic resonance imaging for non-invasive imaging of the plaque and its characterization in terms of its various components (i.e., thickness, lipid, fibrous, calcium, or thrombus). Finally, we will describe the potential of quantitative analysis in describing of plaque constituents with improved reproducibility.
Keywords: clinical imaging, atherosclerosis, magnetic resonance imaging, quantitative analysis
Current Pharmaceutical Design
Title: New Technological Developments in the Clinical Imaging of Atherosclerotic Plaque
Volume: 9 Issue: 29
Author(s): Luigi Landini, Maria Filomena Santarelli, Alessandro Pingitore and Vincenzo Positano
Affiliation:
Keywords: clinical imaging, atherosclerosis, magnetic resonance imaging, quantitative analysis
Abstract: Direct visualization of the composition of the atherosclerotic plaque during its natural history and after therapeutic intervention may be helpful in detecting lesions with high risk of acute events and in understanding progression and regression of the disease. A wide variety of invasive and non-invasive imaging techniques is available to detect clue aspects of atherosclerosis from the early stage to the clinical evidence appearance. We will firstly review the ongoing technological and clinical research on both invasive and noninvasive techniques. Afterward, we will discuss in detail the use of high-resolution, multicontrast magnetic resonance imaging for non-invasive imaging of the plaque and its characterization in terms of its various components (i.e., thickness, lipid, fibrous, calcium, or thrombus). Finally, we will describe the potential of quantitative analysis in describing of plaque constituents with improved reproducibility.
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Cite this article as:
Landini Luigi, Santarelli Filomena Maria, Pingitore Alessandro and Positano Vincenzo, New Technological Developments in the Clinical Imaging of Atherosclerotic Plaque, Current Pharmaceutical Design 2003; 9 (29) . https://dx.doi.org/10.2174/1381612033453794
DOI https://dx.doi.org/10.2174/1381612033453794 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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