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Current Gene Therapy

Editor-in-Chief

ISSN (Print): 1566-5232
ISSN (Online): 1875-5631

Modified Envelope Glycoproteins to Retarget Retroviral Vectors

Author(s): Catherine Haynes, Otto Erlwein and Barbara S. Schnierle

Volume 3, Issue 5, 2003

Page: [405 - 410] Pages: 6

DOI: 10.2174/1566523034578267

Price: $65

Abstract

A conceptual breakthrough in gene therapy would be gene transfer vector that could be systemically applied, allowing targeted gene transfer into a predetermined cell type. The host range of a retroviral vector is determined by the interaction of the viral envelope glycoprotein (Env) and the retrovirus receptor on the surface of the host cell. In this review, we describe the current efforts to engineer targeted envelope glycoproteins, which can be incorporated into retroviral particles and are capable of delivering genes in a highly specific manner.

Keywords: murine leukemia virus, targeting, vector, envelope, virus entry, host range


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