Abstract
Gabapentin is an antiepileptic drug, which decreases neuronal excitability and may act by increasing the availability of gamma-aminobutyric acid or by inhibiting Ca2+ channels. It has safe pharmacokinetic and side effect profiles. Not surprisingly, it has been tested as a treatment in a number of psychiatric conditions. The most robust evidence exists for it as an efficacious treatment in both social phobia and panic disorder. However, the extant literature indicates that it also holds promise in the treatment of other anxiety disorders, alcohol and cocaine dependence, nonrefractory bipolar disorder, as well as in behavioral agitation. Further, controlled, investigations of gabapentins effectiveness in these disorders / conditions merit due consideration, especially given their associated morbidity and lost productivity.
Keywords: gabapentin, pharmacology, pregnancy, lactation, psychiatric disorder
Current Neuropharmacology
Title: Pharmacology and Therapeutics of Gabapentin in the Treatment of Psychiatric Disorders; Present and Future Perspectives
Volume: 1 Issue: 3
Author(s): J. L. Megna, M. M. Iqbal and A. Aneja
Affiliation:
Keywords: gabapentin, pharmacology, pregnancy, lactation, psychiatric disorder
Abstract: Gabapentin is an antiepileptic drug, which decreases neuronal excitability and may act by increasing the availability of gamma-aminobutyric acid or by inhibiting Ca2+ channels. It has safe pharmacokinetic and side effect profiles. Not surprisingly, it has been tested as a treatment in a number of psychiatric conditions. The most robust evidence exists for it as an efficacious treatment in both social phobia and panic disorder. However, the extant literature indicates that it also holds promise in the treatment of other anxiety disorders, alcohol and cocaine dependence, nonrefractory bipolar disorder, as well as in behavioral agitation. Further, controlled, investigations of gabapentins effectiveness in these disorders / conditions merit due consideration, especially given their associated morbidity and lost productivity.
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Cite this article as:
Megna L. J., Iqbal M. M. and Aneja A., Pharmacology and Therapeutics of Gabapentin in the Treatment of Psychiatric Disorders; Present and Future Perspectives, Current Neuropharmacology 2003; 1 (3) . https://dx.doi.org/10.2174/1570159033477125
DOI https://dx.doi.org/10.2174/1570159033477125 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
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