Abstract
Disintegrins represent a family of polypeptides released in the venoms of Viperidae and Crotalidae snakes (vipers and rattlesnakes) by the proteolytic processing of multidomain metalloproteinases, which selectively block the function of β1 and β3 integrin receptors. Research on disintegrins is relevant for understanding the biology of viper venom toxins, but also provides information of new structural determinants involved in integrin recognition that may be useful in both, basic and clinical research. The role of the composition, conformation and concerted dynamics of the integrin inhibitory loop and the C-terminal tail in determining the selective inhibition of integrin receptors is discussed.
Keywords: crotalidae snakes, hemorrhage, metalloproteinases, integrin-ligand interactions, svmps molecules
Current Pharmaceutical Design
Title: Structure-Function Correlations of Snake Venom Disintegrins
Volume: 11 Issue: 7
Author(s): Juan J. Calvete
Affiliation:
Keywords: crotalidae snakes, hemorrhage, metalloproteinases, integrin-ligand interactions, svmps molecules
Abstract: Disintegrins represent a family of polypeptides released in the venoms of Viperidae and Crotalidae snakes (vipers and rattlesnakes) by the proteolytic processing of multidomain metalloproteinases, which selectively block the function of β1 and β3 integrin receptors. Research on disintegrins is relevant for understanding the biology of viper venom toxins, but also provides information of new structural determinants involved in integrin recognition that may be useful in both, basic and clinical research. The role of the composition, conformation and concerted dynamics of the integrin inhibitory loop and the C-terminal tail in determining the selective inhibition of integrin receptors is discussed.
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Cite this article as:
Calvete J. Juan, Structure-Function Correlations of Snake Venom Disintegrins, Current Pharmaceutical Design 2005; 11 (7) . https://dx.doi.org/10.2174/1381612053381783
DOI https://dx.doi.org/10.2174/1381612053381783 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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