Chemistry and Biological Activities of Caffeic Acid Derivatives from Salvia miltiorrhiza

Title: Chemistry and Biological Activities of Caffeic Acid Derivatives from Salvia miltiorrhiza

Volume: 12 Issue: 2

Author(s): Ren-Wang Jiang, Kit-Man Lau, Po-Ming Hon, Thomas C. W. Mak, Kam-Sang Woo and Kwok-Pui Fung

Affiliation:

Keywords: caffeic acid derivative, salvianolic acid, antioxidant, anti-ischemia reperfusion, anti-thrombosis, anti-hypertension, anti-fibrosis, antivirus, antitumor, salvia miltiorrhiza

Abstract: Caffeic acid (3,4-dihydroxycinnamic acid), one of the most common phenolic acids, frequently occurs in fruits, grains and dietary supplements for human consumption as simple esters with quinic acid or saccharides, and are also found in traditional Chinese herbs. Caffeic acid derivatives occur as major water-soluble components of Salvia miltiorrhiza, including caffeic acid monomers and a wide variety of oligomers. This review provides up-to-date coverage of this class of phenolic acids in regard to structural classification, natural resources, chemical and biosyntheses, analytical methods and biological activities including antioxidant, anti-ischemia reperfusion, anti-thrombosis, antihypertension, anti-fibrosis, antivirus and antitumor properties. Special attention is paid to both structural classification and biological activities. The structural diversity and the pronounced biological activities encountered in the caffeic acid derivatives of S. miltiorrhiza indicate that this class of compounds is worthy of further studies that may lead to new drug discovery.

Cite this article as:

Jiang Ren-Wang, Lau Kit-Man, Hon Po-Ming, Mak C. W. Thomas, Woo Kam-Sang and Fung Kwok-Pui, Chemistry and Biological Activities of Caffeic Acid Derivatives from Salvia miltiorrhiza, Current Medicinal Chemistry 2005; 12 (2) . https://dx.doi.org/10.2174/0929867053363397