Abstract
As inductive tissues for the initiation of antigen-specific T and B cell responses, the various mucosa-associated lymphoid tissues (MALT) of the aerodigestive tract, which include gut-associated lymphoid tissue (GALT), nasopharynx-associated lymphoid tissue (NALT) and bronchus-associated lymphoid tissue (BALT), share many histological and immunological characteristics. However, recent advances in our molecular and cellular understanding of immunological development have revealed that the various types of MALT also exhibit different molecular and cellular interactions for their organogenesis. In this review, we delineate the distinctive features of GALT, NALT and BALT and seek to show the role played by those features in the regulation of mucosal tissue organogenesis, the mucosal immune system, and mucosal homeostasis, all in an attempt to provide insights which might lead to a prospective mucosal vaccine.
Keywords: gut-associated lymphoid tissue, nasopharynx-associated lymphoid tissue, bronchus-associated lymphoid tissue, peyers patches, isolated lymphoid follicles, dendritic cells, tumor necrosis factor, epithelial cells, organogenesis, mucosal vaccine
Current Molecular Medicine
Title: Mucosa-Associated Lymphoid Tissues in the Aerodigestive Tract: Their Shared and Divergent Traits and Their Importance to the Orchestration of the Mucosal Immune System
Volume: 5 Issue: 6
Author(s): Jun Kunisawa, Satoshi Fukuyama and Hiroshi Kiyono
Affiliation:
Keywords: gut-associated lymphoid tissue, nasopharynx-associated lymphoid tissue, bronchus-associated lymphoid tissue, peyers patches, isolated lymphoid follicles, dendritic cells, tumor necrosis factor, epithelial cells, organogenesis, mucosal vaccine
Abstract: As inductive tissues for the initiation of antigen-specific T and B cell responses, the various mucosa-associated lymphoid tissues (MALT) of the aerodigestive tract, which include gut-associated lymphoid tissue (GALT), nasopharynx-associated lymphoid tissue (NALT) and bronchus-associated lymphoid tissue (BALT), share many histological and immunological characteristics. However, recent advances in our molecular and cellular understanding of immunological development have revealed that the various types of MALT also exhibit different molecular and cellular interactions for their organogenesis. In this review, we delineate the distinctive features of GALT, NALT and BALT and seek to show the role played by those features in the regulation of mucosal tissue organogenesis, the mucosal immune system, and mucosal homeostasis, all in an attempt to provide insights which might lead to a prospective mucosal vaccine.
Export Options
About this article
Cite this article as:
Kunisawa Jun, Fukuyama Satoshi and Kiyono Hiroshi, Mucosa-Associated Lymphoid Tissues in the Aerodigestive Tract: Their Shared and Divergent Traits and Their Importance to the Orchestration of the Mucosal Immune System, Current Molecular Medicine 2005; 5 (6) . https://dx.doi.org/10.2174/1566524054863924
DOI https://dx.doi.org/10.2174/1566524054863924 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Phosphodiesterase 3 (PDE3): Structure, Localization and Function
Cardiovascular & Hematological Agents in Medicinal Chemistry Non-Analgesic Effects of Opioids: Cardiovascular Effects of Opioids and their Receptor Systems
Current Pharmaceutical Design Recent Progress of Small Molecular VEGFR Inhibitors as Anticancer Agents
Mini-Reviews in Medicinal Chemistry Anti-TNF Antibodies in Inflammatory Bowel Disease: Do We Finally Know How it Works?
Current Drug Targets Prevention and Treatment of Alzheimer Disease and Aging: Antioxidants
Mini-Reviews in Medicinal Chemistry Chinese Medicinal Herbs as Source of Antioxidant Compounds – Where Tradition Meets the Future
Current Medicinal Chemistry Flax Terpenoid Pathway as a Source of Health Promoting Compounds
Mini-Reviews in Medicinal Chemistry Subject Index To Volume 12
Current Pharmaceutical Design Recent Advances in the Synthesis of Pyrazole Derivatives Using Multicomponent Reactions
Current Organic Synthesis Identification of Enzyme Inhibitors from Phage-Displayed Combinatorial Peptide Libraries
Combinatorial Chemistry & High Throughput Screening Recent Developments in Nano-Drug Delivery Systems Loaded by Phytochemicals for Wound Healing
Mini-Reviews in Medicinal Chemistry Effects of Static Magnetic Fields on Blood Pressure in Animals and Humans
Current Hypertension Reviews Subject Index To Volume 2
Current Medicinal Chemistry - Anti-Cancer Agents Natural Products Targeting Cancer Stem Cells: A Revisit
Current Medicinal Chemistry Structure-Activity Relationships of Histamine H2 Receptor Ligands+
Mini-Reviews in Medicinal Chemistry Modelling the Neurovascular Unit and the Blood-Brain Barrier with the Unique Function of Pericytes
Current Neurovascular Research Biologic Characteristics of Bone Marrow Mesenchymal Stem Cells in Myelodysplastic Syndromes
Current Stem Cell Research & Therapy Anti-Diabetic Compounds and their Patent Information: An Update
Recent Patents on Inflammation & Allergy Drug Discovery Histone Deacetylase Inhibitors: An Attractive Strategy for Cancer Therapy
Current Medicinal Chemistry On the Role of Neuropeptides in the Hypothalamic Regulation of Food Intake
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents