Voltammetric Insights in the Transfer of Ionizable Drugs Across Biomimetic Membranes - Recent Achievements

Title: Voltammetric Insights in the Transfer of Ionizable Drugs Across Biomimetic Membranes - Recent Achievements

Volume: 10 Issue: 7

Author(s): Rubin Gulaboski, Fernanda Borges, Carlos M. Pereira, M. Natnlia D.S. Cordeiro, Jorge Garrido and A. Fernando Silva

Affiliation:

Keywords: Partition coefficients, ionisable drugs, three-phase electrode, voltammetry, biomimetic membranes liquid-liquid interface

Abstract: The latest results of voltammetric research on the ionic transfer process of ionisable drugs across bare and lipid-modified liquid-liquid interfaces are reviewed. In recent years, two voltammetric methods have been extensively applied to this purpose, i.e. the classical four electrode voltammetry at the interface between two immiscible electrolyte solutions, and the “three-phase electrode.” Thus, a brief background of the methodologies and some successful examples of their application are highlighted in this work. Particular attention is given to the ionic transfer kinetics and to the electrochemical characterization of the drug-membrane interactions between the ionized drugs and lipid-modified interfaces. Future trends in this area are also mentioned in connection with high-throughput assessment of ADMET properties of drugs.

Cite this article as:

Gulaboski Rubin, Borges Fernanda, Pereira M. Carlos, Cordeiro Natnlia D.S. M., Garrido Jorge and Silva Fernando A., Voltammetric Insights in the Transfer of Ionizable Drugs Across Biomimetic Membranes - Recent Achievements, Combinatorial Chemistry & High Throughput Screening 2007; 10 (7) . https://dx.doi.org/10.2174/138620707782152399