Abstract
Recent work indicates that the expression of Eph and ephrin proteins is upregulated after injury in the central nervous system (CNS). Although to date, much of the interest in these protein families in the nervous system has been on their roles during development, their presence in the adult CNS at multiple time points after injury suggest that they play significant roles in key aspects of the nervous systems response to damage. Several fundamental features of Eph and ephrin biology, such as bidirectional signaling, promiscuity of ligand-receptor binding, and potential cis regulation of function, present challenges for the formulation of rational and effective Eph/ephrin based strategies for CNS axon regeneration. However, recent work that have identified specific functions for individual Ephs and ephrins in injury-induced phenomena such as axon sprouting, cellular remodeling, and scar formation has begun to tease apart their contributions and may provide a number of potential entry points for beneficial therapeutic intervention.
Keywords: Eph, ephrin, central nervous system, injury, axon, regeneration, therapy, nerve, damage
Current Pharmaceutical Design
Title: Eph/ephrin Signaling as a Potential Therapeutic Target After Central Nervous System Injury
Volume: 13 Issue: 24
Author(s): J. Du, C. Fu and D.W. Sretavan
Affiliation:
Keywords: Eph, ephrin, central nervous system, injury, axon, regeneration, therapy, nerve, damage
Abstract: Recent work indicates that the expression of Eph and ephrin proteins is upregulated after injury in the central nervous system (CNS). Although to date, much of the interest in these protein families in the nervous system has been on their roles during development, their presence in the adult CNS at multiple time points after injury suggest that they play significant roles in key aspects of the nervous systems response to damage. Several fundamental features of Eph and ephrin biology, such as bidirectional signaling, promiscuity of ligand-receptor binding, and potential cis regulation of function, present challenges for the formulation of rational and effective Eph/ephrin based strategies for CNS axon regeneration. However, recent work that have identified specific functions for individual Ephs and ephrins in injury-induced phenomena such as axon sprouting, cellular remodeling, and scar formation has begun to tease apart their contributions and may provide a number of potential entry points for beneficial therapeutic intervention.
Export Options
About this article
Cite this article as:
J. Du , C. Fu and D.W. Sretavan , Eph/ephrin Signaling as a Potential Therapeutic Target After Central Nervous System Injury, Current Pharmaceutical Design 2007; 13 (24) . https://dx.doi.org/10.2174/138161207781368594
DOI https://dx.doi.org/10.2174/138161207781368594 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Nanomedicine in Therapeutic Intervention of Tuberculosis Meningitis
Current Nanoscience Arboviral Encephalitis and RNAi Treatment
Central Nervous System Agents in Medicinal Chemistry Renin-Angiotensin System in Central Nervous System Diseases and its Interaction with COVID-19
Current Medicinal Chemistry Apoptosis: A Key in Neurodegenerative Disorders
Current Neurovascular Research The Dental Effects of Meningococcal Septicaemia: A Case Series
Current Pediatric Reviews Disentangling the Intricacies of Migraine: A Review
CNS & Neurological Disorders - Drug Targets Lignans and Neolignans Anti-tuberculosis Identified by QSAR and Molecular Modeling
Combinatorial Chemistry & High Throughput Screening Syphilis and HIV Co-Infection: When is Lumbar Puncture Indicated?
Current HIV Research Exploring Optic Nerve Axon Regeneration
Current Neuropharmacology Azoles as Effective Antifungal Agents: Trends, Scope and Relevance
The Natural Products Journal Lysosomal Storage Diseases and the Blood-Brain Barrier
Current Pharmaceutical Design Chronic Progressive Multiple Sclerosis – Pathogenesis of Neurodegeneration and Therapeutic Strategies
Current Neuropharmacology A Review of the Potential Receptors of Migraine with a Special Emphasis on CGRP to Develop an Ideal Antimigraine Drug
Current Molecular Pharmacology Structural Aspects of Peptides with Immunomodulating Activity
Mini-Reviews in Medicinal Chemistry Antiphospholipid Antibody-Mediated Thrombotic Mechanisms in Antiphospholipid Syndrome: Towards Pathophysiology-Based Treatment
Current Pharmaceutical Design Antiangiogenic Therapy in Malignant Glioma: Promise and Challenge
Current Pharmaceutical Design Prokaryotic Substrate-Binding Proteins as Targets for Antimicrobial Therapies
Current Drug Targets Post Dural Puncture Headache and Hypertension
Current Hypertension Reviews Role of EGFR Inhibitors in the Treatment of Central Nervous System Metastases from Non-Small Cell Lung Cancer
Current Cancer Drug Targets Eight Stranded β -Barrel and Related Outer Membrane Proteins: Role in Bacterial Pathogenesis
Protein & Peptide Letters