Abstract
New developments in the utilities of some carbon nucleophiles in heterocyclic synthesis are reviewed. General synthetic routes based on the utilization of carbon nucleophiles of active methylene are discussed. The major methods and modifications are analyzed. Heterocycles are ubiquitous in all kind of compounds of interest, and among all the possible synthetic methods of achieving their introduction into a structure, probably the use of a carbon nucleophile analogues are the most direct one. The present review deals with the generation and synthetic of carbon nucleophile, which uses as scaffold for the heterocyclic synthesis, and can be considered as an update review. Therefore the only references published upon the second quarter of 2003 are included, and the same restrictions to the literature coverage apply.
Keywords: Thiophene Derivatives, pyrrole derivatives, intermolecular Michael addition, Carbanions, Benzothiophenes, Pyran Derivatives
Current Organic Chemistry
Title: Utilities of Some Carbon Nucleophiles in Heterocyclic Synthesis
Volume: 11 Issue: 10
Author(s): H. M. F. Madkour and A. S. H. Elgazwy
Affiliation:
Keywords: Thiophene Derivatives, pyrrole derivatives, intermolecular Michael addition, Carbanions, Benzothiophenes, Pyran Derivatives
Abstract: New developments in the utilities of some carbon nucleophiles in heterocyclic synthesis are reviewed. General synthetic routes based on the utilization of carbon nucleophiles of active methylene are discussed. The major methods and modifications are analyzed. Heterocycles are ubiquitous in all kind of compounds of interest, and among all the possible synthetic methods of achieving their introduction into a structure, probably the use of a carbon nucleophile analogues are the most direct one. The present review deals with the generation and synthetic of carbon nucleophile, which uses as scaffold for the heterocyclic synthesis, and can be considered as an update review. Therefore the only references published upon the second quarter of 2003 are included, and the same restrictions to the literature coverage apply.
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Cite this article as:
H. M. F. Madkour and A. S. H. Elgazwy , Utilities of Some Carbon Nucleophiles in Heterocyclic Synthesis, Current Organic Chemistry 2007; 11 (10) . https://dx.doi.org/10.2174/138527207781024030
DOI https://dx.doi.org/10.2174/138527207781024030 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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