Abstract
The relationship between hypertension, antihypertensive treatments and the risk of renal-cell cancer (RCC) remains still controversial. To evaluate the strength of the evidence provided by the epidemiological literature on this topic, a MEDLINE search of the papers published from 1966 to 2006 was performed. A total of 18 studies were included in the analysis. Pooled estimates of the effects of interest were obtained by fitting random effect models to the original data. The effects of some characteristics of the studies were considered as putative sources of heterogeneity of the estimates. Significant increased risks of RCC associated with hypertension (pooled odds ratio 1.62; 95% confidence interval: 1.24 to 2.12), as well as with the use of both diuretics (1.43; 1.12 to 1.83) and no diuretics (1.51; 1.21 to 1.87) antihypertensive drugs were observed. The effect of diuretics was significant in women (1.92; 1.59 to 2.33), but not in men (1.18; 0.93 to 1.49). Allowance for the known risk factors of RCC appreciably modified the effect of no diuretic antihypertensives making its pooled estimate not significant (1.17; 0.94 to 1.46). Although the pooled estimates show that both, hypertension and hypertensive therapy, are statistically associated with increased risk of RCC, experimental data and a closer look on the original data from epidemiologic literature, show that available evidence are still uncertain and need to be further investigated.
Keywords: Antihypertensive medicaments, hypertension, meta-analysis, renal-cell cancer
Current Drug Safety
Title: Hypertension, Antihypertensive Therapy and Renal-Cell Cancer: A Meta-Analysis
Volume: 2 Issue: 2
Author(s): Giovanni Corrao, Lorenza Scotti, Vincenzo Bagnardi and Roberto Sega
Affiliation:
Keywords: Antihypertensive medicaments, hypertension, meta-analysis, renal-cell cancer
Abstract: The relationship between hypertension, antihypertensive treatments and the risk of renal-cell cancer (RCC) remains still controversial. To evaluate the strength of the evidence provided by the epidemiological literature on this topic, a MEDLINE search of the papers published from 1966 to 2006 was performed. A total of 18 studies were included in the analysis. Pooled estimates of the effects of interest were obtained by fitting random effect models to the original data. The effects of some characteristics of the studies were considered as putative sources of heterogeneity of the estimates. Significant increased risks of RCC associated with hypertension (pooled odds ratio 1.62; 95% confidence interval: 1.24 to 2.12), as well as with the use of both diuretics (1.43; 1.12 to 1.83) and no diuretics (1.51; 1.21 to 1.87) antihypertensive drugs were observed. The effect of diuretics was significant in women (1.92; 1.59 to 2.33), but not in men (1.18; 0.93 to 1.49). Allowance for the known risk factors of RCC appreciably modified the effect of no diuretic antihypertensives making its pooled estimate not significant (1.17; 0.94 to 1.46). Although the pooled estimates show that both, hypertension and hypertensive therapy, are statistically associated with increased risk of RCC, experimental data and a closer look on the original data from epidemiologic literature, show that available evidence are still uncertain and need to be further investigated.
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Cite this article as:
Corrao Giovanni, Scotti Lorenza, Bagnardi Vincenzo and Sega Roberto, Hypertension, Antihypertensive Therapy and Renal-Cell Cancer: A Meta-Analysis, Current Drug Safety 2007; 2 (2) . https://dx.doi.org/10.2174/157488607780598296
DOI https://dx.doi.org/10.2174/157488607780598296 |
Print ISSN 1574-8863 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3911 |

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