Abstract
DNA-damage checkpoints sense and respond to genomic damage. Human Rad9 (hRad9), an evolutionarily conserved gene with multiple functions for preserving genomic integrity, plays multiple roles in fundamental biological processes, including the regulation of the DNA damage response, cell cycle checkpoint control, DNA repair, apoptosis, transcriptional regulation, exonuclease activity, ribonucleotide synthesis and embryogenesis. This review examines work that provides significant insight into the molecular mechanisms of several individual cellular processes which might be beneficial for developing novel therapeutic approaches to cancerous diseases with genomic instability.
Keywords: DNA damage, replication, checkpoint, cancer
Current Genomics
Title: Multiple Functions of Rad9 for Preserving Genomic Integrity
Volume: 7 Issue: 8
Author(s): Kazuhiro Ishikawa, Hideshi Ishii, Toshiyuki Saito and Keiichi Ichimura
Affiliation:
Keywords: DNA damage, replication, checkpoint, cancer
Abstract: DNA-damage checkpoints sense and respond to genomic damage. Human Rad9 (hRad9), an evolutionarily conserved gene with multiple functions for preserving genomic integrity, plays multiple roles in fundamental biological processes, including the regulation of the DNA damage response, cell cycle checkpoint control, DNA repair, apoptosis, transcriptional regulation, exonuclease activity, ribonucleotide synthesis and embryogenesis. This review examines work that provides significant insight into the molecular mechanisms of several individual cellular processes which might be beneficial for developing novel therapeutic approaches to cancerous diseases with genomic instability.
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Cite this article as:
Ishikawa Kazuhiro, Ishii Hideshi, Saito Toshiyuki and Ichimura Keiichi, Multiple Functions of Rad9 for Preserving Genomic Integrity, Current Genomics 2006; 7 (8) . https://dx.doi.org/10.2174/138920206779315746
DOI https://dx.doi.org/10.2174/138920206779315746 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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