Integrins and Cancer: Gene Expression, Epigenetics and Metastasis

Title: Integrins and Cancer: Gene Expression, Epigenetics and Metastasis

Volume: 7 Issue: 5

Author(s): T. Stuardi, S. M.O. Phipps and T. O. Tollefsbol

Affiliation:

Keywords: Integrin, cancer, Twist, ILK, MMP, epigenetic, HoxD3

Abstract: Integrins are composed of a variety of binding subunits that are responsible for interacting with the extracellu-lar matrix and intracellular signaling pathways. Among their various functions, integrins have the ability to augment cellu-lar adhesion, influence cytoskeletal architecture, activate tyrosine kinase and affect cell survival. Many investigations have demonstrated a correlation between the regulation of integrin expression and tumor invasiveness and proliferation. Integrins affect transcription factors Twist and HoxD3, epigenetic regulation, matrix metalloproteinases, insulin-like growth factors, integrin-linked kinases and adherens junctions, which are all important components of tumorigenicity. Cancer cells modify their functional genomic composition thereby altering integrin expression. Understanding the rela-tionship between integrin expression and tumor activities could provide an important strategy for cancer treatment.

Cite this article as:

Stuardi T., M.O. Phipps S. and O. Tollefsbol T., Integrins and Cancer: Gene Expression, Epigenetics and Metastasis, Current Genomics 2006; 7 (5) . https://dx.doi.org/10.2174/138920206778604377