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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Pharmacological and Clinical Studies on Purine Nucleoside Analogs- New Anticancer Agents

Author(s): E. Lech-Maranda, A. Korycka and T. Robak

Volume 6, Issue 5, 2006

Page: [575 - 581] Pages: 7

DOI: 10.2174/138955706776876212

Price: $65

Abstract

More recently, three novel purine nucleoside analogs, including clofarabine, nelarabine and immucillin H, have been introduced into clinical trials. These agents have different metabolic properties, novel mechanism of action, and are undergoing phase I-II clinical studies for the treatment of hematopoietic malignancies. Pharmacology and anticancer activity of PNA are the subjects of this review.

Keywords: Cladribine, fludarabine, pentostatin, clofarabine, nelarabine, immucillin H


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