Functional Chemokine Receptors in Allergic Diseases: Is CCR8 a Novel Therapeutic Target?

Title: Functional Chemokine Receptors in Allergic Diseases: Is CCR8 a Novel Therapeutic Target?

Volume: 6 Issue: 4

Author(s): E. Mitsuyama, Y. Kunori, T. Kamimura and O. Kaminuma

Affiliation:

Keywords: Allergy, atopic dermatitis, bronchial asthma, chemokine, eosinophil, knockout mouse, Th2 cell

Abstract: CC chemokine receptor (CCR) 8, which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. This review represents an overview of the functional roles of CCR8 in the pathogenesis of eosinophilic inflammation and debates the potential of recently developed CCR8 antagonists to treat allergic disorders.

Cite this article as:

Mitsuyama E., Kunori Y., Kamimura T. and Kaminuma O., Functional Chemokine Receptors in Allergic Diseases: Is CCR8 a Novel Therapeutic Target?, Mini-Reviews in Medicinal Chemistry 2006; 6 (4) . https://dx.doi.org/10.2174/138955706776361394