Effects of the Natural Isoflavonoid Genistein on Growth, Signaling Pathways and Gene Expression of Matrix Macromolecules by Breast Cancer Cells

Title: Effects of the Natural Isoflavonoid Genistein on Growth, Signaling Pathways and Gene Expression of Matrix Macromolecules by Breast Cancer Cells

Volume: 6 Issue: 3

Author(s): O. C. Kousidou, G. N. Tzanakakis and N. K. Karamanos

Affiliation:

Keywords: genistein, estrogens, estrogen receptor, signaling, breast cancer

Abstract: Genistein is a well known protein tyrosine kinase inhibitor. It is structurally similar to 17- estradiol and exerts antiestrogenic effects. It also affects the signal transduction components Akt, FAK, ErbB-2 and Bcl-2. Key enzymes implicated in cancer invasion are also affected by genistein. A critical evaluation of the effects of genistein on breast cancer growth, signaling and gene expression is presented in this review.

Cite this article as:

Kousidou C. O., Tzanakakis N. G. and Karamanos K. N., Effects of the Natural Isoflavonoid Genistein on Growth, Signaling Pathways and Gene Expression of Matrix Macromolecules by Breast Cancer Cells, Mini-Reviews in Medicinal Chemistry 2006; 6 (3) . https://dx.doi.org/10.2174/138955706776073420