Microcystin Produces Disparate Effects on Liver Cells in a Dose Dependent Manner

Title: Microcystin Produces Disparate Effects on Liver Cells in a Dose Dependent Manner

Volume: 6 Issue: 3

Author(s): Lars Herfindal and Frode Selheim

Affiliation:

Keywords: Microcystin, protein phosphatases, PP1, PP2A, reactive oxygen species, cancer, apoptosis, mitochondria

Abstract: In this review we present recent studies on the effects of the protein phosphatase inhibitor microcystin on mammalian cells. Whereas high concentrations of microcystin promote liver cell death induced by ROS signalling without the involvement of typical apoptotic proteins, intermediate doses activate classic apoptotic pathways. Low concentrations however, increase liver cell survival and proliferation, and can cause primary liver cancer.

Cite this article as:

Herfindal Lars and Selheim Frode, Microcystin Produces Disparate Effects on Liver Cells in a Dose Dependent Manner, Mini-Reviews in Medicinal Chemistry 2006; 6 (3) . https://dx.doi.org/10.2174/138955706776073475