Abstract
The production of single enantiomers of drug intermediates has become increasingly important in the pharmaceutical industry. Chiral intermediates and fine chemicals are in high demand by both the pharmaceutical and agrochemical industries for the preparation of bulk drug substances and agricultural products. The enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enatioselectivities has been demonstrated. In this article, biocatalytic processes are described for the synthesis of chiral intermediates for anti-hypertensive drugs, lipid lowering drugs, anti-cancer agents, antiviral agents, β-3- and β-2-receptor receptor agonists, melatonin receptor agonists, a tryptase inhibitor, retinoic acid γ-specific antagonist, and anti-
Keywords: HIV Protease Inhibitor, Enzymatic Synthesis, biotransformation, Crixivan, Aminoacylation, Paclitaxel, Orally Active Taxane
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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