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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Fluoroquinolones: An Important Class of Antibiotics Against Tuberculosis

Author(s): Marcus V. N. De Souza, Thatyana R. A. Vasconcelos, Mauro V. d. Almeida and Silvia H. Cardoso

Volume 13, Issue 4, 2006

Page: [455 - 463] Pages: 9

DOI: 10.2174/092986706775527965

Price: $65

Abstract

Tuberculosis (TB) is a global health problem due to the lack of new drugs in the market and also due to the advent of multidrug resistant strains (MDR). This disease affects around 8 million people and kills almost 3 million people each year and it is estimated that there are 1 billion infected with TB worldwide. Due to this problem fluoroquinolones have attracted much attention as the new class of anti TB drugs due to their fewer toxic side effects, improved pharmacokinetic properties and extensive and potent activity against Grampositive and Gram-negative bacteria, including resistant strains. In this present review we report fluoroquinolones as a promising new class of anti TB.

Keywords: Tuberculosis, antibiotics, fluoroquinolones


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