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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Perspective

Domino/Cascade and Multicomponent Reactions for the Synthesis of Thiazole Derivatives

Author(s): Mohammad A. Alam*

Volume 26, Issue 4, 2022

Published on: 24 March, 2022

Page: [343 - 347] Pages: 5

DOI: 10.2174/1385272826666220214110118

Abstract

Substituted thiazoles are widely known as natural products, approved drugs, and a number of synthetic compounds as bioactive agents. Due to the worth of this heterocycle nucleus, a large number of synthetic methodologies have been reported over the years to synthesize its derivatives. In this perspective, recent advances in the synthesis of thiazole compounds by using domino/cascade and multicomponent approaches have been summarized.

Keywords: Domino/cascade reaction, multicomponent reaction, thiazole, thiazoline, fused-thiazole, anticancer, thiazolo-androstenone, isothiazole.

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