Login Register Cart 0
Generic placeholder image

Current Drug Research Reviews

Editor-in-Chief

ISSN (Print): 2589-9775
ISSN (Online): 2589-9783

Back
Journal Home About Journal Editorial Board Current Issue Volumes/Issues
Subscribe
Review Article

Plant-based Natural Products for Wound Healing: A Critical Review

Author(s): Shalini Ramalingam, Moola Joghee Nanjan Chandrasekar* and Moola Joghee Nanjan

Volume 14, Issue 1, 2022

Published on: 27 December, 2021

Page: [37 - 60] Pages: 24

DOI: 10.2174/2589977513666211005095613

Price: $65

Abstract

Wound healing is an intricate process consisting of four overlapping phases, namely hemostasis, inflammation, proliferation, and remodelling. Effective treatment of wounds depends upon the interaction of appropriate cell types, cell surface receptors, and the extracellular matrix with the therapeutic agents. Several approaches currently used for treating wounds, such as advanced wound dressing, growth factor therapy, stem cell therapy, and gene therapy, are not very effective and lead to impaired healing. Further, repeated use of antibiotics to treat open wounds leads to multi- drug resistance. Today there is considerable interest in plant-based drugs as they are believed to be safe, inexpensive, and more suitable for chronic wounds. For example, a large number of plant- based extracts and their bioactive compounds have been investigated for wound healing. In recent years the structural and mechanistic diversity of natural products have become central players in the search for newer therapeutic agents. In the present review, a thorough critical survey of the traditionally used plant-based drugs used worldwide for wound healing with special reference to the natural products/bioactive compounds isolated and screened is presented. It is hoped that this review will attract the attention of the research community involved in newer drug design and development for wound healing.

Keywords: Wound healing, excision, incision, growth factor, breaking strength, epithelialization.

« Previous Next »
Graphical Abstract

[1]
Nagar HK, Srivastava AK, Srivastava R, Kurmi M, Chandel HS, Ranawat MS. Pharmacological investigation of the wound healing activity of Cestrum nocturnum (L.) ointment in wistar albino rats. J Pharm (Cairo) 2016; 8
[2]
Frances S. Physiology of wound healing. Newborn Infant Nurs Rev 2001; 1(1): 43-52.
[3]
Palmieri B, Vadalà M, Laurino C. Review of the molecular mechanisms in wound healing: new therapeutic targets? J Wound Care 2017; 26(12): 765-75.
[http://dx.doi.org/10.12968/jowc.2017.26.12.765] [PMID: 29244975]
[4]
Christian A, Bekoe EO, Boakye YD, Dapaah SO, Appiah T, Bekoe SO. Medicinal plants and natural products with demonstrated wound healing properties. In: Alexandrescu V-A, Ed. Wound Healing - New insights into Ancient Challenges. IntechOpen 2016.
[http://dx.doi.org/10.5772/63574]
[5]
Goldberg SR, Diegelmann RF. Wound healing primer. Surg Clin North Am 2010; 90: 1133-46.
[http://dx.doi.org/10.1016/j.suc.2010.08.003] [PMID: 21074032]
[6]
Marume A, Matope G, Katsande S, et al. Wound healing properties of selected plants used in ethnoveterinary medicine. Front Pharmacol 2017; 8: 544.
[http://dx.doi.org/10.3389/fphar.2017.00544] [PMID: 28932192]
[7]
Avinash S, Gowda DV, Suresh J, Ram A, Srivastava A, Osmani RAM. Formulation and evaluation of topical gel using Eupatorium glandulosum michx. for wound healing activity. Pharm Lett 2016; 8(8): 255-66.
[8]
Kumar B, Vijayakumar M, Govindarajan R, Pushpangadan P. Ethnopharmacological approaches to wound healing- exploring medicinal plants of India. J Ethnopharmacol 2007; 114(2): 103-13.
[http://dx.doi.org/10.1016/j.jep.2007.08.010] [PMID: 17884316]
[9]
Umeh VN, Ilodigwe EE, Ajaghaku DL, Erhirhie EO, Moke GE, Akah PA. Wound-healing activity of the aqueous leaf extract and fractions of Ficus exasperata (moraceae) and its safety evaluation on albino rats. J Tradit Complement Med 2014; 4(4): 246-52.
[http://dx.doi.org/10.4103/2225-4110.139105] [PMID: 25379466]
[10]
Budovsky A, Yarmolinsky L, Ben-Shabat S. Effect of medicinal plants on wound healing. Wound Repair Regen 2015; 23(2): 171-83.
[http://dx.doi.org/10.1111/wrr.12274] [PMID: 25703533]
[11]
Hasanoglu A, Ara C, Ozen S, Kali K, Senol M, Ertas E. Efficacy of micronized flavonoid fraction in healing of clean and infected wounds. Int J Angiol 2001; 10(1): 41-4.
[http://dx.doi.org/10.1007/BF01616343] [PMID: 11178786]
[12]
Stipcevic T, Piljac J, Berghe VD. Effect of different flavonoids on collagen synthesis in human fibroblasts. Plant Foods Hum Nutr 2006; 61(1): 29-34.
[http://dx.doi.org/10.1007/s11130-006-0006-8] [PMID: 16642409]
[13]
Martin P, Nunan R. Cellular and molecular mechanisms of repair in acute and chronic wound healing. Br J Dermatol 2015; 173(2): 370-8.
[http://dx.doi.org/10.1111/bjd.13954] [PMID: 26175283]
[14]
Teller P, White TK. The physiology of wound healing: Injury through maturation. Perioper Nurs Clin 2011; 6: 159-70.
[http://dx.doi.org/10.1016/j.cpen.2011.04.001]
[15]
Enoch S, Grey JE, Harding KG. ABC of wound healing. Non-surgical and drug treatments. BMJ 2006; 332(7546): 900-3.
[http://dx.doi.org/10.1136/bmj.332.7546.900] [PMID: 16613966]
[16]
Levine JM. The effect of oral medication on wound healing. Adv Skin Wound Care 2012; 30(3): 137-42.
[http://dx.doi.org/10.1097/01.asw.0000512112.60254.28] [PMID: 28198745]
[17]
Shrivastav A, Mishra AK, Alia SS, Ahmad A, Abuzinadah MF, Khan NA. In vivo models for assessment of wound healing potential: A systematic review. Wound Medicine 2018; 20: 43-53.
[http://dx.doi.org/10.1016/j.wndm.2018.01.003]
[18]
Altoé LS, Alves RS, Sarandy MM, Morais-Santos M, Novaes RD, Gonçalves RV. Does antibiotic use accelerate or retard cutaneous repair? A systematic review in animal models. PLoS One 2019; 14(10): e0223511.
[http://dx.doi.org/10.1371/journal.pone.0223511] [PMID: 31600279]
[19]
White RJ, Cooper R, Kingsley A. Wound colonization and infection: The role of topical antimicrobials. Br J Nurs 2001; 10(9): 563-78.
[http://dx.doi.org/10.12968/bjon.2001.10.9.9387] [PMID: 12066030]
[20]
Siddique Z, Shah GM, Ahmed HM, et al. Ethnophytotherapy practices for wound healing among populations of district Haripur, KPK, Pakistan. Evid Based Complement Alternat Med 2019; 2019: 4591675.
[http://dx.doi.org/10.1155/2019/4591675] [PMID: 31379961]
[21]
Hermann PTA, Martin AW. Pharmacology of Curcuma longa. Planta Med 1991; 57(1): 1-7.
[http://dx.doi.org/10.1055/s-2006-960004] [PMID: 2062949]
[22]
Sidhu GS, Singh AK, Thaloor D, et al. Enhancement of wound healing by curcumin in animals. Wound Repair Regen 1998; 6(2): 167-77.
[http://dx.doi.org/10.1046/j.1524-475X.1998.60211.x] [PMID: 9776860]
[23]
Jagetia GC, Rajanikant GK. Role of curcumin, a naturally occurring phenolic compound of turmeric in accelerating the repair of excision wound, in mice whole-body exposed to various doses of γ-radiation. J Surg Res 2004; 120(1): 127-38.
[http://dx.doi.org/10.1016/j.jss.2003.12.003] [PMID: 15172199]
[24]
Davis RH, Leitner MG, Russo JM, Byrne ME. Wound healing. Oral and topical activity of aloe vera. J Am Podiatr Med Assoc 1989; 79(11): 559-62.
[http://dx.doi.org/10.7547/87507315-79-11-559] [PMID: 2607423]
[25]
Choi SW, Son BW, Son YS, Park YI, Lee SK, Chung MH. The wound-healing effect of a glycoprotein fraction isolated from aloe vera. Br J Dermatol 2001; 145(4): 535-45.
[http://dx.doi.org/10.1046/j.1365-2133.2001.04410.x] [PMID: 11703278]
[26]
Villegas LF, Marcalo A, Martin J, et al. (+)-epi-alpha-bisbolol is the wound-healing principle of peperomia galioides: investigation of the in vivo wound-healing activity of related terpenoids. J Nat Prod 2001; 64: 1357-9.
[http://dx.doi.org/10.1021/np0102859] [PMID: 11678668]
[27]
Kamatou GPP, Viljoen AM. A review of the application and pharmacological properties of α-bisabolol and α-bisabolol-rich oils. J Am Oil Chem Soc 2009; 87(1): 1-7.
[http://dx.doi.org/10.1007/s11746-009-1483-3]
[28]
Souza R, Cardoso M, Menezes C, Silva J, De Sousa D, Batista J. Gastroprotective activity of α-terpineol in two experimental models of gastric ulcer in rats. Daru 2011; 19(4): 277-81.
[PMID: 22615669]
[29]
Philip CS, Monique SJS, Julia S, Peter JH, Peter G. Wound healing activity of acylated iridoid glycosides from scrophularia nodosa. Phytother Res 2002; 16: 33-5.
[http://dx.doi.org/10.1002/ptr.798]
[30]
HamdifNilgun O, Seval K, Yusuf O, Husnu CB. Effects of gentopicroside, sweroside, swertiamarine, secoiridioids from gentian (gentiana lutea ssp, sympyandra) on cultured chicken embryonic fibroblast. Planta Med 2006; 72: 289-94.
[http://dx.doi.org/10.1055/s-2005-916198] [PMID: 16557467]
[31]
Huang Y, Lin J, Yi W, et al. Research on the potential mechanism of gentiopicroside against gastric cancer based on network pharmacology. Drug Des Devel Ther 2020; 14: 5109-18.
[http://dx.doi.org/10.2147/DDDT.S270757] [PMID: 33262572]
[32]
Gupta A, Kumar R, Pal K, Singh V, Banerjee PK, Sawhney RC. Influence of sea buckthorn (Hippophae rhamnoides L.) flavone on dermal wound healing in rats. Mol Cell Biochem 2006; 290(1-2): 193-8.
[http://dx.doi.org/10.1007/s11010-006-9187-6] [PMID: 16633732]
[33]
Singh S, Krishna V, Mankani K, Manjunatha B, Vidya S, Manohara Y. Wound healing activity of the leaf extracts and deoxyelephantopin isolated from Elephantopus scaber Linn. Indian J Pharmacol 2005; 37(4): 238-42.
[http://dx.doi.org/10.4103/0253-7613.16570]
[34]
Mehmood T, Maryam A, Ghramh HA, Khan M, Ma T. Deoxyelephantopin and isodeoxyelephantopin as potential anticancer agents with effects on multiple signaling pathways. Molecules 2017; 22(6): 1013.
[http://dx.doi.org/10.3390/molecules22061013] [PMID: 28635648]
[35]
Papageorgiou VP. Wound healing properties of naphthaquinone pigments from Alkanna tinctoria. Experientia 1978; 34(11): 1499-501.
[http://dx.doi.org/10.1007/BF01932375] [PMID: 720485]
[36]
Ozgen U, Ikbal M, Hacimuftuoglu A, et al. Fibroblast growth stimulation by extracts and compounds of Onosma argentatum roots. J Ethnopharmacol 2006; 104(1-2): 100-3.
[http://dx.doi.org/10.1016/j.jep.2005.08.052] [PMID: 16226418]
[37]
Zhu Y, Zhong Y, Long X, et al. Deoxyshikonin isolated from Arnebia euchroma inhibits colorectal cancer by down-regulating the PI3K/Akt/mTOR pathway. Pharm Biol 2019; 57(1): 412-23.
[http://dx.doi.org/10.1080/13880209.2019.1626447] [PMID: 31230505]
[38]
Anoop KS, Anuj S, James W, Subhashree M, Keith S, Rajeshkumar NV. Picroliv accelerates epithelialization and angiogenesis in rat wound. Planta Med 2007; 73: 251-6.
[39]
Tang T, Yin L, Yang J, Shan G. Emodin, an anthraquinone derivative from Rheum officinale Baill, enhances cutaneous wound healing in rats. Eur J Pharmacol 2007; 567(3): 177-85.
[http://dx.doi.org/10.1016/j.ejphar.2007.02.033] [PMID: 17540366]
[40]
Dong X, Fu J, Yin X, et al. Emodin: a review of its pharmacology, toxicity and pharmacokinetics. Phytother Res 2016; 30(8): 1207-18.
[http://dx.doi.org/10.1002/ptr.5631] [PMID: 27188216]
[41]
Harish BG, Krishna V, Santosh KHS, Khadeer ABM, Sharath R, Kumara SHM. Wound healing activity and docking of glycogen-synthase-kinase-3-beta-protein with isolated triterpenoid lupeol in rats. Phytomedicine 2008; 15(9): 763-7.
[http://dx.doi.org/10.1016/j.phymed.2007.11.017] [PMID: 18222664]
[42]
Siddique HR, Saleem M. Beneficial health effects of lupeol triterpene: a review of preclinical studies. Life Sci 2011; 88(7-8): 285-93.
[http://dx.doi.org/10.1016/j.lfs.2010.11.020] [PMID: 21118697]
[43]
Khadeer Ahamed BM, Krishna V, Malleshappa KH. In vivo wound healing activity of the methanolic extract and its isolated constituent, gulonic acid γ-lactone, obtained from Grewia tiliaefolia. Planta Med 2009; 75(5): 478-82.
[http://dx.doi.org/10.1055/s-0029-1185315] [PMID: 19219758]
[44]
Süntar IP, Akkol EK, Yilmazer D, et al. Investigations on the in vivo wound healing potential of Hypericum perforatum L. J Ethnopharmacol 2010; 127(2): 468-77.
[http://dx.doi.org/10.1016/j.jep.2009.10.011] [PMID: 19833187]
[45]
Raza A, Xu X, Sun H, Tang J, Zhen O. Pharmacological activities and pharmacokinetic study of hyperoside: a short review. Trop J Pharm Res 2017; 16(2): 483-9.
[http://dx.doi.org/10.4314/tjpr.v16i2.30]
[46]
Al-Dhabi NA, Arasu MV, Park CH, Park SU. An up-to-date review of rutin and its biological and pharmacological activities. EXCLI J 2015; 14: 59-63.
[PMID: 26535031]
[47]
Jayachandran M, Wu Z, Ganesan K, Khalid S, Chung SM, Xu B. Isoquercetin upregulates antioxidant genes, suppresses inflammatory cytokines and regulates AMPK pathway in streptozotocin-induced diabetic rats. Chem Biol Interact 2019; 303: 62-9.
[http://dx.doi.org/10.1016/j.cbi.2019.02.017] [PMID: 30817903]
[48]
Kulkarni S, Patil P, Virupaksha B, Alpana G, Prashant K, Baikerikar S. Molecular dynamics, docking and qsar analysis of napthoquinone derivatives as topoisomerase i inhibitors. International Journal Of Computational Bioinformatics And In Silico Modeling 2013; 2(5): 223-33.
[49]
Annan K, Houghton PJ. Two novel lupane triterpenoids from Paullinia pinnata L. with fibroblast stimulatory activity. J Pharm Pharmacol 2010; 62(5): 663-8.
[http://dx.doi.org/10.1211/jpp.62.05.0016] [PMID: 20609071]
[50]
Akdemir Z, Kahraman C, Tatlı II, Küpeli Akkol E, Süntar I, Keles H. Bioassay-guided isolation of anti-inflammatory, antinociceptive and wound healer glycosides from the flowers of Verbascum mucronatum Lam. J Ethnopharmacol 2011; 136(3): 436-43.
[http://dx.doi.org/10.1016/j.jep.2010.05.059] [PMID: 20621642]
[51]
Shukla A, Rasik AM, Jain GK, Shankar R, Kulshrestha DK, Dhawan BN. In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. J Ethnopharmacol 1999; 65(1): 1-11.
[http://dx.doi.org/10.1016/S0378-8741(98)00141-X] [PMID: 10350364]
[52]
Liu M, Dai Y, Li Y, et al. Madecassoside isolated from Centella asiatica herbs facilitates burn wound healing in mice. Planta Med 2008; 74(8): 809-15.
[http://dx.doi.org/10.1055/s-2008-1074533] [PMID: 18484522]
[53]
Wu F, Bian D, Xia Y, et al. Identification of major active ingredients responsible for burn wound healing of centella asiatica herbs. Evid Based Complement Alternat Med 2012; 2012: 848093.
[http://dx.doi.org/10.1155/2012/848093] [PMID: 23346217]
[54]
Kumara Swamy HM, Krishna V, Shankarmurthy K, et al. Wound healing activity of embelin isolated from the ethanol extract of leaves of Embelia ribes Burm. J Ethnopharmacol 2007; 109(3): 529-34.
[http://dx.doi.org/10.1016/j.jep.2006.09.003] [PMID: 17034970]
[55]
Choung M-G, Baek I-Y, Kang S-T, et al. Isolation and determination of anthocyanins in seed coats of black soybean (Glycine max (L.) Merr.). J Agric Food Chem 2001; 49(12): 5848-51.
[http://dx.doi.org/10.1021/jf010550w] [PMID: 11743773]
[56]
Nizamutdinova IT, Kim YM, Chung JI, et al. Anthocyanins from black soybean seed coats stimulate wound healing in fibroblasts and keratinocytes and prevent inflammation in endothelial cells. Food Chem Toxicol 2009; 47(11): 2806-12.
[http://dx.doi.org/10.1016/j.fct.2009.08.016] [PMID: 19733615]
[57]
Cleber AS, Renato M, Torsten B, et al. Catechin derivatives from Parapiptadenia rigida with in vitro wound-healing properties. J Nat Prod 2010; 73(12): 2035-41.
[http://dx.doi.org/10.1021/np100523s] [PMID: 21080642]
[58]
Sharath R, Harish BG, Krishna V, Sathyanarayana BN, Swamy HM. Wound healing and protease inhibition activity of Bacoside-A, isolated from Bacopa monnieri wettest. Phytother Res 2010; 24(8): 1217-22.
[http://dx.doi.org/10.1002/ptr.3115] [PMID: 20213670]
[59]
Clericuzio MST, Bruno B, Elia R, Simona M, Laura C, Arianna La. R. Flavonoid Oligo glycosides from Ophioglossum vulgatum L. having wound healing properties. Planta Med 2012; 78: 1639-44.
[http://dx.doi.org/10.1055/s-0032-1315149] [PMID: 22936389]
[60]
Tseng HL, Li CJ, Huang LH, et al. Quercetin 3-O-methyl ether protects FL83B cells from copper induced oxidative stress through the PI3K/Akt and MAPK/Erk pathway. Toxicol Appl Pharmacol 2012; 264(1): 104-13.
[http://dx.doi.org/10.1016/j.taap.2012.07.022] [PMID: 22842013]
[61]
Clericuzio M, Burlando B, Gandini G, et al. Keratinocyte wound healing activity of galactoglycerolipids from the fern Ophioglossum vulgatum L. J Nat Med 2014; 68(1): 31-7.
[http://dx.doi.org/10.1007/s11418-013-0759-y] [PMID: 23508568]
[62]
Petpiroon N, Suktap C, Pongsamart S, Chanvorachote P, Sukrong S. Kaempferol-3-O-rutinoside from Afgekia mahidoliae promotes keratinocyte migration through FAK and Rac1 activation. J Nat Med 2015; 69(3): 340-8.
[http://dx.doi.org/10.1007/s11418-015-0899-3] [PMID: 25783411]
[63]
Suktap C, Lee HK, Amnuaypol S, Suttisri R, Sukrong S. Wound healing effect of flavonoid glycosides from afgekia mahidolae B.L.Burtt & Chermsir. leaves. Rec Nat Prod 2018; 12(4): 391-6.
[http://dx.doi.org/10.25135/rnp.39.17.10.166]
[64]
Yadav E, Singh D, Yadav P, Verma A. Attenuation of dermal wounds via downregulating oxidative stress and inflammatory markers by protocatechuic acid rich n-butanol fraction of Trianthema portulacastrum Linn. in wistar albino rats. Biomed Pharmacother 2017; 96: 86-97.
[http://dx.doi.org/10.1016/j.biopha.2017.09.125] [PMID: 28965012]
[65]
Ghosh S, Samanta A, Mandal NB, Bannerjee S, Chattopadhyay D. Evaluation of the wound healing activity of methanol extract of Pedilanthus tithymaloides (L.) Poit leaf and its isolated active constituents in topical formulation. J Ethnopharmacol 2012; 142(3): 714-22.
[http://dx.doi.org/10.1016/j.jep.2012.05.048] [PMID: 22683906]
[66]
Kimura Y, Sumiyoshi M, Kawahira K, Sakanaka M. Effects of ginseng saponins isolated from Red Ginseng roots on burn wound healing in mice. Br J Pharmacol 2006; 148(6): 860-70.
[http://dx.doi.org/10.1038/sj.bjp.0706794] [PMID: 16770323]
[67]
Kim YS, Cho IH, Jeong MJ, et al. Therapeutic effect of total ginseng saponin on skin wound healing. J Ginseng Res 2011; 35(3): 360-7.
[http://dx.doi.org/10.5142/jgr.2011.35.3.360] [PMID: 23717081]
[68]
Kim WK, Song SY, Oh WK, et al. Wound-healing effect of ginsenoside Rd from leaves of Panax ginseng via cyclic AMP-dependent protein kinase pathway. Eur J Pharmacol 2013; 702(1-3): 285-93.
[http://dx.doi.org/10.1016/j.ejphar.2013.01.048] [PMID: 23399764]
[69]
Sharifi R, Pasalar P, Kamalinejad M, et al. The effect of silymarin (Silybum marianum) on human skin fibroblasts in an in vitro wound healing model. Pharm Biol 2013; 51(3): 298-303.
[http://dx.doi.org/10.3109/13880209.2012.721789] [PMID: 23137300]
[70]
Tabari SA, Carpi S, Polini B, et al. Topical application of silymarin enhances cutaneous wound healing in rats. S Afr J Bot 2019; 124: 494-8.
[http://dx.doi.org/10.1016/j.sajb.2019.06.004]
[71]
Reza TM, Ahamd O, Adel M-A, Abotorab T-N. Silibinin regulates matrix metalloproteinase 3 (stromelysine1) gene expression, hexoseamines and collagen production during rat skin wound healing. Phytother Res 2013; 27(8): 1149-53.
[http://dx.doi.org/10.1002/ptr.4839] [PMID: 22976003]
[72]
Hua X, Qina N. Dehydrodiconiferyl alcohol from Silybum marianum (L.) Gaertn accelerates wound healing via inactivating NF-kB pathways in macrophages. J Pharm Pharmacol 2020; 72(2): 305-17.
[http://dx.doi.org/10.1111/jphp.13205] [PMID: 31742713]
[73]
Sung SH, Park SH, Song SY, et al. Epidermal regeneration by ent-16α, 17-dihydroxy-kauran-19-oic acid isolated from Siegesbeckia pubescens. Cell Prolif 2011; 44(6): 527-36.
[http://dx.doi.org/10.1111/j.1365-2184.2011.00786.x] [PMID: 21992237]
[74]
Balekar N, Nakpheng T, Katkam NG, Srichana T. Wound healing activity of ent-kaura-9(11),16-dien-19-oic acid isolated from Wedelia trilobata (L.) leaves. Phytomedicine 2012; 19(13): 1178-84.
[http://dx.doi.org/10.1016/j.phymed.2012.07.014] [PMID: 22921749]
[75]
Nagappan T, Segaran TC, Wahid ME, Ramasamy P, Vairappan CS. Efficacy of carbazole alkaloids, essential oil and extract of Murraya koenigii in enhancing subcutaneous wound healing in rats. Molecules 2012; 17(12): 14449-63.
[http://dx.doi.org/10.3390/molecules171214449] [PMID: 23519245]
[76]
Dineshkumar B, Mitra A, Mahadevappa M. Antidiabetic and hypolipidemic effects of mahanimbine (carbazole alkaloid) from Murraya koenigii (rutaceae) leaves. Int J Phytomed 2010; 2: 22-30.
[77]
Moura-Letts G, Villegas LF, Marcalo A, Vaisberg AJ, Hammond GB. In vivo wound-healing activity of oleanolic acid derived from the acid hydrolysis of Anredera diffusa. J Nat Prod 2006; 69: 978-9.
[http://dx.doi.org/10.1021/np0601152]
[78]
Kuonen R, Weissenstein U, Urech K, et al. Effects of lipophilic extract of viscum album l. and oleanolic acid on migratory activity of nih/3t3 fibroblasts and on hacat keratinocytes. Evid Based Complement Alternat Med 2013; 2013: 718105.
[http://dx.doi.org/10.1155/2013/718105] [PMID: 24379890]
[79]
Muhammad AA, Pauzi NA, Arulselvan P, Abas F, Fakurazi S. In vitro wound healing potential and identification of bioactive compounds from Moringa oleifera Lam. BioMed Res Int 2013; 2013: 974580.
[http://dx.doi.org/10.1155/2013/974580] [PMID: 24490175]
[80]
Süntar IP, Akkol EK, Yalçin FN, Koca U, Keleş H, Yesilada E. Wound healing potential of Sambucus ebulus L. leaves and isolation of an active component, quercetin 3-O-glucoside. J Ethnopharmacol 2010; 129(1): 106-14.
[http://dx.doi.org/10.1016/j.jep.2010.01.051] [PMID: 20132876]
[81]
Zheng YZ, Deng G, Liang Q, Chen DF, Guo R, Lai RC. Antioxidant activity of quercetin and its glucosides from propolis: a theoretical study. Sci Rep 2017; 7(1): 7543.
[http://dx.doi.org/10.1038/s41598-017-08024-8] [PMID: 28790397]
[82]
Esposito D, Munafo JP Jr, Lucibello T, Baldeon M, Komarnytsky S, Gianfagna TJ. Steroidal glycosides from the bulbs of Easter lily (Lilium longiflorum Thunb.) promote dermal fibroblast migration in vitro. J Ethnopharmacol 2013; 148(2): 433-40.
[http://dx.doi.org/10.1016/j.jep.2013.04.032] [PMID: 23644411]
[83]
Di R, Murray AF, Xiong J, et al. Lily steroidal glycoalkaloid promotes early inflammatory resolution in wounded human fibroblasts. J Ethnopharmacol 2020; 258: 112766.
[http://dx.doi.org/10.1016/j.jep.2020.112766] [PMID: 32194231]
[84]
Mukherjee H, Ojha D, Bharitkar YP, et al. Evaluation of the wound healing activity of Shorea robusta, an Indian ethnomedicine, and its isolated constituent(s) in topical formulation. J Ethnopharmacol 2013; 149(1): 335-43.
[http://dx.doi.org/10.1016/j.jep.2013.06.045] [PMID: 23838474]
[85]
Avula MK, Sudhakar BT, Ravi SP, Reddanna , Latha J. Wound healing activity of flavonoid fraction isolated from the stem bark of Butea monosperma (Lam) in albino wistar rats. Eur J Exp Biol 2013; 3(6): 1-6.
[86]
Bui NT, Ho MT, Kim YM, Lim Y, Cho M. Flavonoids promoting HaCaT migration: II. Molecular mechanism of 4′,6,7-trimethoxyisoflavone via NOX2 activation. Phytomedicine 2014; 21(4): 570-7.
[http://dx.doi.org/10.1016/j.phymed.2013.10.010] [PMID: 24388604]
[87]
Islamie KR, Stefanie HC. Wound healing activity of aucubin on hyperglycemic rat. J Young Pharm 2018; 10(2)(Suppl.): s136-9.
[88]
Yuan X, Han L, Fu P, et al. Cinnamaldehyde accelerates wound healing by promoting angiogenesis via up-regulation of PI3K and MAPK signaling pathways. Lab Invest 2018; 98(6): 783-98.
[http://dx.doi.org/10.1038/s41374-018-0025-8]
[89]
Özbilgin S, Acıkara OB, Akkol EK, Süntar I, Keleş H, İşcan GS. In vivo wound-healing activity of Euphorbia characias subsp. wulfenii: isolation and quantification of quercetin glycosides as bioactive compounds. J Ethnopharmacol 2018; 224: 400-8.
[http://dx.doi.org/10.1016/j.jep.2018.06.015] [PMID: 29920357]
[90]
Si N, Kanazawa H, Okuyama K, et al. Involvement of catechols in acteoside in the activation of promatrix metalloproteinase-2 and membrane type-1-matrix metalloproteinase expression via a phosphatidylinositol-3-kinase pathway in human dermal fibroblasts. Biol Pharm Bull 2018; 41(10): 1530-6.
[http://dx.doi.org/10.1248/bpb.b18-00107] [PMID: 30270322]
[91]
Mai L-M, Lin C-Y, Chen C-Y, Tsai Y-C. Synergistic effect of bismuth subgallate and borneol, the major components of Sulbogins on the healing of skin wound. Biomaterials 2003; 24: 3005-12.
[http://dx.doi.org/10.1016/S0142-9612(03)00126-1] [PMID: 12895572]
[92]
Hsiao C-Y, Hung C-Y, Tsai T-H, Chak K-F. A study of the wound healing mechanism of a traditional chinese medicine, Angelica sinensis, using a proteomic approach. Evid Based Complement Alternat Med 2012; 2012: 14.
[http://dx.doi.org/10.1155/2012/467531]
[93]
Ghaisas MM, Kshirsagar SB, Sahane RS. Evaluation of wound healing activity of ferulic acid in diabetic rats. Int Wound J 2014; 11(5): 523-32.
[PMID: 23236955]
[94]
Ebeling S, Naumann K, Pollok S, et al. From a traditional medicinal plant to a rational drug: understanding the clinically proven wound healing efficacy of birch bark extract. PLoS One 2014; 9(1): e86147.
[http://dx.doi.org/10.1371/journal.pone.0086147] [PMID: 24465925]
[95]
Metelmann HR, Brandner JM, Schumann H, et al. Accelerated reepithelialization by triterpenes: proof of concept in the healing of surgical skin lesions. Skin Pharmacol Physiol 2015; 28(1): 1-11.
[http://dx.doi.org/10.1159/000357501] [PMID: 25034442]
[96]
Scheffler A. The wound healing properties of betulin from birch bark from bench to bedside. Planta Med 2019; 85(7): 524-7.
[http://dx.doi.org/10.1055/a-0850-0224] [PMID: 30856673]
[97]
Siyumbwa SN, Ekeuku SO, Amini F, Emerald NM, Sharma D, Okechukwu PN. Wound healing and antibacterial activities of 2-pentadecanone in streptozotocin-induced type 2 diabetic rats. Pharmacogn Mag 2019; 15: S71-7.
[http://dx.doi.org/10.4103/pm.pm_444_18]

Rights & Permissions Print Cite
Article Metrics
21
1
© 2024 Bentham Science Publishers | Privacy Policy