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Current Neuropharmacology

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ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

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Mini-Review Article

The Epigenetic Mechanisms Involved in Chronic Pain in Rodents: A Mini- Review

Author(s): Ting Xu, Cui-Cui Liu and Wen-Jun Xin*

Volume 20, Issue 6, 2022

Published on: 17 March, 2022

Page: [1011 - 1021] Pages: 11

DOI: 10.2174/1570159X19666210924104757

Price: $65

Abstract

Chronic pain is a common distressing neurological disorder and about 30% of the global population suffers from it. In addition to being highly prevalent, chronic pain causes a heavy economic and social burden. Although substantial progress has been achieved to dissect the underlying mechanism of chronic pain in the past few decades, the incidence and treatment of this neurological illness is yet not properly managed in clinical practice. While nerve injury-, chemotherapy- or inflammation-induced functional regulation of gene expression in the dorsal root ganglion and spinal cord are extensively reported to be involved in the pathogenic process of chronic pain, the specific mechanism of these altered transcriptional profile still remains unclear. Recent studies have shown that epigenetic mechanisms, including DNA/RNA methylation, histone modification and circular RNAs regulation, are involved in the occurrence and development of chronic pain. In this review, we provide a description of research on the role of epigenetic mechanism in chronic pain, summarize the latest clinical and preclinical advance in this field, and propose the potential directions for further research to elucidate the molecular mechanism underlying the pathogenesis of chronic pain.

Keywords: Chronic pain, DNA methylation, RNA N6-methyladenosine modification, histone acetylation, circular RNA, dorsal root ganglion, spinal cord.

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