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Review Article

Dichrostachys cinerea: Ethnomedicinal Uses, Phytochemistry and Pharmacological Activities - A Review

Author(s): Ofentse Mazimba*, Tebogo E. Kwape and Goabaone Gaobotse

Volume 12, Issue 3, 2022

Published on: 04 January, 2022

Article ID: e060821195380 Pages: 11

DOI: 10.2174/2210315511666210806144540

Price: $65

Abstract

Indigenous and medicinal plants have proven crucial to the health of mankind for a very long time. Dichrostachys cinerea is a traditional herb used in the treatment of a variety of human diseases in African and Indian traditional medicine. This paper reviews the ethnomedicinal uses, phytochemical constituents, pharmacology, and toxicity of D. cinerea, in order to provide scientific consensus for further research and exploitation of the therapeutic potential of this plant. Information was accessed by literature searches in different sources including Science Direct, PubMed, and Google Scholar. The findings of this review paper highlight D. Cinerea as an important component of African and Indian traditional medicine. D. cinerea is traditionally used in the treatment of rheumatism, diabetes, coughs, asthma, kidney disorders, gonorrhea, syphilis, malaria, tuberculosis, epilepsy, snake bites, pains, wounds, boils, burns, toothache, headache, and scabies. D. cinerea displays diverse phytochemistry, with a wide range of isolated compounds that have well-documented biological activities. D. cinerea has demonstrated both in vitro and in vivo biological activities. In vitro, biological activities exhibited include enzyme inhibition, antibacterial, anti-fungal, and antimalarial activities. In vivo activities demonstrated by D. cinerea include anti-inflammatory, antidiarrheal, anti-analgesic, hepatoprotective, anti-urolithiatic, anti-lice, anti-dandruff, and neuropharmacological activities. Animal studies have elucidated the non-toxicity of D. cinerea for the ethanol root extract and methanol and water leaf extracts. It is vital that future studies on D. cinerea focus on the mechanisms of action behind these biological activities for both the crude extract and its chemical compounds. These studies could lead to clinical trials to confirm biological activities found in animal studies. Further studies on multi-target network pharmacology, and molecular docking technology of D. cinerea sub fractions for enzyme inhibitions and neuropharmacological activities are of great importance and could accelerate the process of pharmaceutical development of this plant.

Keywords: Ethnopharmacology, Dichrostachys cinerea, traditional uses, herbal medicine, pharmacological activities, biological activities.

Graphical Abstract

[1]
Balch, J.F.; Stenger, M.; Young-Balch, R. Prescription for drug alternatives: all-natural options for better health without the side effects; John Wiley & Sons, Inc.: Hoboken, New Jersey, 2008.
[2]
James, P.B.; Wardle, J.; Steel, A.; Adams, J. Traditional, complementary and alternative medicine use in Sub-Saharan Africa: A systematic review. BMJ Glob. Health, 2018, 3(5), e000895.
[http://dx.doi.org/10.1136/bmjgh-2018-000895] [PMID: 30483405]
[3]
Pan, S.Y.; Zhou, S.F.; Gao, S.H.; Yu, Z.L.; Zhang, S.F.; Tang, M.K.; Sun, J.N.; Ma, D.L.; Han, Y.F.; Fong, W.F.; Ko, K.M. New perspectives on how to discover drugs from herbal medicines: Cam’s outstanding contribution to modern therapeutics. Evid. Based Complement. Alternat. Med., 2013, 2013, 627375.
[http://dx.doi.org/10.1155/2013/627375] [PMID: 23634172]
[4]
Maridass, M.; Britto, A.J. Origins of plant derived medicines. Ethnobotanical Leaflets, 2008, 12, 373-387.
[5]
Leistner, O.A. Flora of Southern Africa.South African Government Printer, 1963.
[6]
Venter, F.; Venter, J.A. Making the most of indigenous trees; Briza Publications: Arcadia, Pretoria, 1996.
[7]
du Puy, D.J.; Labat, J.N.; Rabevohitra, R.; Villiers, J.F.; Bosser, J.; Moat, J. The leguminosae of madagascar.Royal Botanic Gardens: Kew, Richmond, United Kingdom, 2002.
[8]
Mann, A.; Amupitan, J.O.; Oyewale, A.O.; Okogun, J.I.; Ibrahim, K.; Oladosu, P.; Lawson, I.; Olajide, I.; Nnamdi, A. Evaluation of in vitro antimycobacterial activity of Nigerian plants used for treatment of respiratory diseases. Afr. J. Biotechnol., 2008, 7, 1630-1636.
[http://dx.doi.org/10.5897/AJB08.438]
[9]
Curtis, B.A.; Mannheimer, C.A. Tree atlas of Namibia; National Botanical Research Institute of Namibia: Windhoek, 2005.
[10]
Pedroso, D.T.; Kaltschmitt, M. Dichrostachys cinerea as a possible energy crop-facts and figures. Biomass Convers. Biorefin., 2012, 2, 41-51.
[http://dx.doi.org/10.1007/s13399-011-0026-y]
[11]
Fowler, D.G.; Lewis, G. Dichrostachys cinerea (L.) Wight & Arn.Prota 11 (2), Medicinal plants 2; Schmelzer, G.H.; Gurib- Fakim, A., Eds.; Wageningen, Netherlands, 2013.
[12]
Dalziel, J.M. The useful plants of west tropical Africa. J. R. Afr. Soc., 1937, 36, 398-399.
[13]
Sunday, O.O.; Uguru, M.O.; Ogbonna, A. Antimicrobial and hypoglycemic effects of Momordica balsamina. Linn. J. Nat. Prod., 2008, 1, 03-09.
[14]
Nadkarni, K.M. Indian materia medica; Popular book depot: Bombay, 1954.
[15]
Aiyer, N.M.A.; Kolammal, M. Pharmacognosy of ayurvedic drugs, kerala, series‐1: number‐8, department of pharmacognosy.University of Kerala: Trivandrum, Kerala, India, 1964.
[16]
Palmer, E.; Pitman, N. Trees of southern Africa covering all known indigenous species in the Republic of South Africa, South-West Africa, Botswana, Lesotho and Swaziland; Balkema: Cape Town, South Africa Botany, 1972, p. 2235..
[17]
Ross, J.H. Dichrostachys. Flora of southern. Africa (Lond.), 1975, 16, 123-129.
[18]
Thomas, J.M.C. Notes d’ethnobotanique africaine: Plantes utilisées dans la région dela Lobaye (AfriqueCentrale). J. Agric. Trop. Bot. Appl., 1959, 6, 370.
[http://dx.doi.org/10.3406/jatba.1959.2562]
[19]
Vergiat, A.M. Plantes magiqueset médicinales des Féticheursdel’Oubangui (Région deBangui). J. Agric. Trop. Bot. Appl., 1969, 16, 343.
[20]
Ouattara, D. Recensement d’espèces végétales employees dans le traitement de l’Asthme bronchique: casdu District d’Abidjan (Côted’Ivoire).Mémoire de maîtrise de botanique et de phytothérapie; University of Abobo-Adjamé: Ivory Coast, 2007.
[21]
Schnell, R. Sur quelques croyances et pratiques concernant les serpents. J. Soc. Afr, 1949, 19, 93-95.
[http://dx.doi.org/10.3406/jafr.1949.2597]
[22]
Sillans, R. Surquel ques plantes médicinales de l’Afrique Centrale. Revue international ede botanique appliquée et d’agriculture tropicale, 31e; , 1951, pp. 345-346.
[23]
Kuber, R.B.; SanthRani, T. Evaluation of neuropharmacological effect of Dichrostachys cinerea root. Int. J. Pharmaceut. Sci. Nanotechnol., 2009, 1, 367-374.
[24]
Chauke, M.A.; Shai, L.J.; Mogale, M.A.; Tshisikhawe, M.P.; Mokgotho, M.P. Medicinal plant use of villagers in the Mopani District, Limpopo Province, South Africa. Afr. J. Tradit. Complement. Altern. Med., 2015, 12, 9-26.
[http://dx.doi.org/10.4314/ajtcam.v12i3.2]
[25]
Varier, P.S. Indian Medicinal Plants, Compendium of 500 species; Arya Vaidya Sala: Kottakkal, 1993, 2, p. 12.
[26]
Sini, K.R.; Sinha, B.N.; Karpagavalli, M. Determining the antioxidant activity of certain medicinal plants of Attapady, (Palakkad), India using DPPH assay. Curr. Biot., 2010, 1, 13-16.
[27]
Neondo, J.O.; Mbithe, C.M.; Njenga, P.K.; Muthuri, C.W. Phytochemical characterization, antibacterial screening and toxicity evaluation of Dichrostachys cinerea. Int. J. Med. Plants. Res, 2012, 1, 032-037.
[28]
Mishra, N.; Pareek, A. Floristic diversity of angiosperms with special reference to their medicinal properties from Kota district of Rajasthan, India. Int. J. Adv. Res. (Indore), 2015, 994-1007.
[29]
Vergiat, A.M. Plantes magiqueset médicinales des Féticheursdel’Oubangui (Région deBangui). J. Agric. Trop. Bot. Appl., 1970, 17, 181.
[30]
Arbonnier, M. Trees, shrubs and lianas of West African dry zones; CIRAD, Margraf Publishers Gmbh, MNHN: Paris, France, 2004.
[31]
Maundu, P.; Tengnäs, B. Useful trees and shrubs for Kenya.Technical Handbook 35; World agroforestry centre - east and central africa regional programme (ICRAF-ECA: Nairobi, Kenya, 2005.
[32]
Fankam, A.G.; Kuete, V.; Voukeng, I.K.; Kuiate, J.R.; Pages, J.M. Antibacterial activities of selected Cameroonian spices and their synergistic effects with antibiotics against multidrug-resistant phenotypes. BMC Complement. Altern. Med., 2011, 11, 104.
[http://dx.doi.org/10.1186/1472-6882-11-104] [PMID: 22044718]
[33]
Burkill, H.M. Families J-L.The useful plants of west tropical Africa, 2nd; Richmond, United Kingdom, 1995, 3, . Royal Botanic Gardens, Kew
[34]
Kambizi, L.; Afolayan, A.J. An ethnobotanical study of plants used for the treatment of sexually transmitted diseases (njovhera) in Guruve District, Zimbabwe. J. Ethnopharmacol., 2001, 77(1), 5-9.
[http://dx.doi.org/10.1016/S0378-8741(01)00251-3] [PMID: 11483371]
[35]
Vaidyaratanam, P.S.V. Indian medicinal plants-a compendium of 500 species; Orient longman limited: Aryavaidyasala, Kottakkal, India, 1994, p. 1..
[36]
Yoganarasimhan, S.N. Medicinal plants of India; Regional research institute (Ayurveda): Bangalore, India, 2000.
[37]
Bekele-Tesemma, A. Useful trees and shrubs for Ethiopia: identification, propagation and management for 17 agro climatic zones; Nairobi, Kenya, 2007.
[38]
Karou, S.D.; Tchacondo, T.; Djikpo Tchibozo, M.A.; Abdoul-Rahaman, S.; Anani, K.; Koudouvo, K.; Batawila, K.; Agbonon, A.; Simpore, J.; de Souza, C. Ethnobotanical study of medicinal plants used in the management of diabetes mellitus and hypertension in the central region of togo. Pharm. Biol., 2011, 49(12), 1286-1297.
[http://dx.doi.org/10.3109/13880209.2011.621959] [PMID: 22077164]
[39]
Maruthupandian, A.; Mohan, V.R.; Kottaimuthu, R. Ethnomedicinal plants used for the treatment of diabetes and jaundice by Palliyar tribals in Sirumalai hills, Western Ghats, Tamil Nadu, India. Indian J. Nat. Prod. Resour., 2011, 2, 493-497.
[40]
Shandukani, P.D.; Tshidino, S.C.; Masoko, P.; Moganedi, K.M. Antibacterial activity and in situ efficacy of Bidens pilosa Linn and Dichrostachys cinerea Wight et Arn extracts against common diarrhoea-causing waterborne bacteria. BMC Complement. Altern. Med., 2018, 18(1), 171.
[http://dx.doi.org/10.1186/s12906-018-2230-9] [PMID: 29859076]
[41]
Vennaposa, S.; Sandeep, S.K.; Sumanthi, K.; Kumar, N.S. Phytochemical and antimicrobial evaluations of Dichrostachys cinerea. Inter. Res. J. Pharm, 2013, 4, 106-111.
[42]
Ribalta, V.; Torres, L.; Hernández, E.; Sueiro, M; Armas, Y.; Ruz, V. Evaluation of antioxidant activity and acute toxicity of aqueous fraction of Dichrostachys cinerea (L.) Wight & Arn. (Mimosaceae) leaves; , 2015.
[43]
Rao, J.M.; Rao, R.J.; Yadav, J.S.; Raghavan, K.V. A process for the preparation of ()-epicatechin from a new natural source namely Dichrostachys cinerea. WIPO, WO, 2004/054994, A1., 2004.
[44]
Bhargava, V.V.; Saluja, A.K.; Dholwani, K.K. Detection of heavy metal contents and proximate analysis of roots of Anogeissus latifolia. J. Pharmacogn. Phytochem., 2013, 1, 61-65.
[45]
Zeid, A.H.; Hifnawy, M.S.; Mohammed, R.S.; Sleem, A.A. Lipoidal contents, analgesic and antipyretic activities of the aerial parts of Dichrostachys cinerea L. J. Herbs Spices Med. Plants, 2015, 21, 118-128.
[http://dx.doi.org/10.1080/10496475.2014.920459]
[46]
Zeid, A.H.; Hifnawy, M.S.; Mohammed, R.S. Anti-tumour activity and phytochemical constituents of the aerial parts of Dichrostachys cinerea L. Planta Med., 2008, 1020-1021.
[47]
Renganayagi, R. Pharmacocgnostic, phytochemical and bioactivity studies on Dichrostachys cinerea (L) Wight and Arn.. PhD Thesis, India, 2013.
[48]
Lavanya, A.; Ambikapathy, V. Preliminary qualitative analysis of phytoconstituents of Dichrostachys cinerea L. J. Pharmacogn. Phytochem., 2016, 5, 86-88.
[49]
Kolapo, A.L.; Okunade, M.B.; Adejumobi, J.A.; Ogundiya, M.O. In vitro antimicrobial activity and phytochemical composition of Dichrostachys cinerea. Med. Aromat. Plant Sci. Biotechnol., 2008, 2, 131-133.
[50]
Aworet-Samseny, R.R.R.; Souza, A.; Kpahé, F.; Konaté, K.; Datté, J.Y. Dichrostachys cinerea (L.) Wight et Arn (Mimosaceae) hydro-alcoholic extract action on the contractility of tracheal smooth muscle isolated from guinea-pig. BMC Complement. Altern. Med., 2011, 11, 23.
[http://dx.doi.org/10.1186/1472-6882-11-23] [PMID: 21414220]
[51]
Ezeonu, C.S.; Ejikeme, C.M. Qualitative and Quantitative Determination of phytochemical contents of indigenous Nigerian softwoods. New J. Sci., 2016.
[http://dx.doi.org/10.1155/2016/5601327]
[52]
Joshi, K.C.; Sharma, T. Triterpenoids and some other constituents from Dichrostachys cinerea. Phytochemistry, 1977, 13, 2010-2011.
[http://dx.doi.org/10.1016/0031-9422(74)85147-2]
[53]
Koudou, J.; Roblot, G.; Wylde, R.; Heitz, A. Constituents of the hexane extract from dichrostachys glomerata. Planta Med., 1994, 60(1), 96-97.
[http://dx.doi.org/10.1055/s-2006-959422] [PMID: 17236025]
[54]
Dadea, J.M.E.; Irie-N’Guessanb, G.; Komlagac, G.; Saya, M.; Okpekona, T.A.; Botia, J.B.; Kablanb, B.J.; Bambaa, E.S. Pyrrolidine alkaloids and their glycosylated derivatives from the root bark of Dichrostachys cinerea (L) Wight & Arn. (Fabaceae). Phytochem. Lett., 2016, 16, 268-276.
[http://dx.doi.org/10.1016/j.phytol.2016.05.002]
[55]
Long, C.; Marcourt, L.; Raux, R.; David, B.; Gau, C.; Menendez, C.; Gao, M.; Laroche, M.F.; Schambel, P.; Delaude, C.; Ausseil, F.; Lavaud, C.; Massiot, G. Meroterpenes from Dichrostachys cinerea inhibit protein farnesyl transferase activity. J. Nat. Prod., 2009, 72(10), 1804-1815.
[http://dx.doi.org/10.1021/np900095z] [PMID: 19761234]
[56]
Fotie, J.; Nkengfack, A.E.; Peter, M.G.; Heydenreich, M.; Fomum, Z.T. Chemical constituents of the ethyl acetate extracts of the stem bark and fruits of Dichrostachys cinerea and the roots of Parkia bicolor. Bull. Chem. Soc. Ethiop., 2004, 18, 111-115.
[http://dx.doi.org/10.4314/bcse.v18i1.61646]
[57]
Zeid, A.H.; Hifnawy, M.S.; Mohammed, R.S. Phenolic compounds and biological activities of Dichrostachys cinerea L. Med. Aromat. Plant Sci. Biotechnol., 2009, 3, 42-49.
[58]
Sanbongi, C.; Osakabe, N.; Natsume, M.; Takizawa, T.; Gomi, S.; Osawa, T. Antioxidative polyphenols isolated from Theobroma cacao. J. Agric. Food Chem., 1998, 46(2), 454-457.
[http://dx.doi.org/10.1021/jf970575o] [PMID: 10554262]
[59]
Makkar, H.P.S.; Becker, K. Isolation of tannins from leaves of some trees and shrubs and their properties. J. Agric. Food Chem., 1994, 42, 731-734.
[http://dx.doi.org/10.1021/jf00039a026]
[60]
Moglad, E.H.; Hamad, A.M.; Fatima, F.; Devanathadesikan, S.V.; Naz, M. Antimicrobial and wound healing activities of certain Sudanese medicinal plants. Saudi J. Biol. Sci., 2020, 27(7), 1766-1772.
[http://dx.doi.org/10.1016/j.sjbs.2020.05.017] [PMID: 32565694]
[61]
Uritu, C.M.; Mihai, C.T.; Stanciu, G-D.; Dodi, G.; Alexa-Stratulat, T.; Luca, A.; Leon-Constantin, M-M.; Stefanescu, R.; Bild, V.; Melnic, S.; Tamba, B.I. Medicinal plants of the family Lamiaceae in pain therapy: A review. Pain Res. Manag., 2018, 2018, 7801543.
[http://dx.doi.org/10.1155/2018/7801543] [PMID: 29854039]
[62]
Tshikalange, T.E.; Mamba, P.; Adebayo, S.A. Antimicrobial, antioxidant and cytotoxicity studies of medicinal plants used in the treatment of sexually transmitted diseases. Inter. J. Pharmacog. Phytochem. Res, 2016, 8, 1891-1895.
[63]
Shukla, A.K.; Shukla, S.; Garg, A.; Garg, S. A review on anti-urolithiatic activity of herbal folk plants. Asian J. Biomater. Res, 2017, 3, 1-11.
[64]
Banso, A.; Adeyemo, S.O. Evaluation of antibacterial properties of tannins isolated from Dichrostachys cinerea. Afr. J. Biotechnol., 2007, 6, 1785-1787.
[http://dx.doi.org/10.5897/AJB2007.000-2262]
[65]
Eisa, M.M.; Almagboul, A.Z.; Omer, M.E.; Elegami, A.A. Antibacterial activity of Dichrostachys cinerea. Fitoterapia, 2000, 71(3), 324-327.
[http://dx.doi.org/10.1016/S0367-326X(99)00171-9] [PMID: 10844173]
[66]
Hassan, H.S.; Sule, M.I.; Musa, A.M.; Musa, K.Y.; Abubakar, M.S.; Hassan, A.S. Anti-inflammatory activity of crude saponin extracts from five Nigerian medicinal plants. Afr. J. Tradit. Complement. Altern. Med., 2011, 9(2), 250-255.
[PMID: 23983342]
[67]
Jayakumari, S.; Rao, G.H.S.; Anbu, J.; Ravichandiran, V. Antidiarrhoeal activity of Dichrostachys cinerea (L.) Wight & Arn. Int. J. Pharm. Pharm. Sci., 2011, 3, 6163.
[68]
Babu, P.S.; Krishna, V.; Maruthi, K.R.; Shankarmurthy, K.; Babu, R.K. Evaluation of acute toxicity and hepatoprotective activity of the methanolic extract of Dichrostachys cinerea (Wight and Arn.) leaves. Pharmacognosy Res., 2011, 3(1), 40-43.
[http://dx.doi.org/10.4103/0974-8490.79114] [PMID: 21731394]
[69]
Bapela, M.J.; Meyer, J.J.; Kaiser, M. In vitro antiplasmodial screening of ethnopharmacologically selected south african plant species used for the treatment of malaria. J. Ethnopharmacol., 2014, 156, 370-373.
[http://dx.doi.org/10.1016/j.jep.2014.09.017] [PMID: 25245771]
[70]
Kimani, P.M.; Mwitari, P.G.; Njagi, S.M.; Kirira, P.G.; Kiboi, D.M. In vitro anti-proliferative activity of selected plant extracts against cervical and prostate cancer cell lines. J. Cancer Sci. Ther., 2018, 10, 9.
[http://dx.doi.org/10.4172/1948-5956.1000555]
[71]
Viol, D.I.; Chagonda, L.S.; Moyo, S.R.; Mericli, A.H. Toxicity and antiviral activities of some medicinal plants used by traditional medical practitioners in Zimbabwe. Am. J. Plant Sci., 2016, 7, 1538-1544.
[http://dx.doi.org/10.4236/ajps.2016.711145]
[72]
Jayakumari, S.; Anbu, J.; Ravichandran, V. Antiurolithiatic activity of Dichrostachys cinerea (L.) Wight&Arn root extract. J. Pharm. Res., 2011, 4, 1206-1208.
[73]
Susithra, E.; Jayakumari, S. Analgesic and anti-inflammatory activities of Dichrostachys cinerea (L.) Wight and Arn. Drug Invention Today, 2018, 10, 361-366.
[74]
Mishra, U.S.; Behera, S.R.; Murphy, P.N.; Manish, K.; Kumar, D. Antibacterial and analgesic effects of the leaves of Dichrostachys Cinerea. Int. J. Pharm. Pharm. Sci., 2009, 1, 230-238.
[75]
Heidari, M.R.; Foroumadi, A.; Noroozi, H.; Samzadeh-Kermani, A.; Azimzadeh, B.S. Study of the anti-inflammatory and analgesic effects of novel rigid benzofuran-3, 4-dihydroxy chalcone by formalin, hot-plate and carrageenan tests in mice. Pak. J. Pharm. Sci., 2009, 22(4), 395-401.
[PMID: 19783518]
[76]
Russo, M.; Coppola, V.; Giannetti, E.; Buonavolontà, R.; Piscitelli, A.; Staiano, A. Oral administration of tannins and flavonoids in children with acute diarrhea: A pilot, randomized, control-case study. Ital. J. Pediatr., 2018, 44(1), 64.
[http://dx.doi.org/10.1186/s13052-018-0497-6] [PMID: 29866147]
[77]
Dudley, D.J. Oxytocin: Use and abuse, science and art. Clin. Obstet. Gynecol., 1997, 40(3), 516-524.
[http://dx.doi.org/10.1097/00003081-199709000-00009] [PMID: 9328731]
[78]
Taur, D.J.; Patil, R.Y. Some medicinal plants with antiasthmatic potential: A current status. Asian Pac. J. Trop. Biomed., 2011, 1(5), 413-418.
[http://dx.doi.org/10.1016/S2221-1691(11)60091-9] [PMID: 23569804]
[79]
Kirthikar, K.R.; Basu, B.D. Indian medicinal plants; CSIR: New Delhi, India, 1975, II, . Publications and Information Division
[80]
Vaidyaratnam, P.S. Indian Medicinal plants. a compendium of 500 species; Orient Longman Ltd: Chennai, India, 1998, 1, p. 10.
[81]
Patel, B.R.; Sharma, P.P. Clinical evaluation of Veerataru (Dichrostachys cinerea Linn.) in the management of Mootrakruchchhra (Dysuria). Ayu, 2013, 34(3), 249-253.
[http://dx.doi.org/10.4103/0974-8520.123105] [PMID: 24501517]

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