Current Pathogenesis of Alzheimer’s Disease and Plants Derived Neuroprotective Phytoconstituents: A Comprehensive Review

Title:Current Pathogenesis of Alzheimer’s Disease and Plants Derived Neuroprotective Phytoconstituents: A Comprehensive Review

Volume: 10

Author(s): Anil K. Pradhan, Bimala Tripathy*, Bimalendu Chowdhury, Sasmita K. Acharjya and Rajaram Das

Affiliation:

• Roland Institute of Pharmaceutical Sciences, Khodasingi, Berhampur-760010, Ganjam, Odisha,India

Keywords: Amyloid beta, amyloid precursor protein, tau hyperphosphorylation, oxidative stress, neuroprotection, phytochemicals.

Abstract:

Background: The exact pathogenesis of Alzheimer’s disease is still a matter to debate. Currently there is no reliable therapy established for Alzheimer’s disease. However, several pieces of evidence suggest that the use of plant based phytoconstituents mainly delays the onset of Alzheimer’s disease. So, in this review, we collect information about the cause of Alzheimer’s disease hypothesis and the neuroprotective effect of phytoconstituents.

Objective: This review paper aimed to analyze the current pathogenesis of Alzheimer’s disease and therapeutic effect of plant phytoconstituents that play a vital role in neuroprotective and antistress activities in Alzheimer’s disease and other neurodegenerative disorders.

Methods: The source of literature review obtained from Scopus, Science Direct, PubMed, Web of Science database, and journal by using Alzheimer’s pathogenesis, neuroinflammation, oxidative stress, amyloid beta, flavonoids, alkaloids are an important part of these review research.

Results: The current review explored different types of pathogenesis involved in Alzheimer’s disease and the role of phytoconstituents in its treatment. The collected information showed that plant based constituents inhibit the major cause of Alzheimer’s disease related to amyloid beta, tau protein, oxidative stress, neuroinflammation, etc.

Conclusion: The study provides the clue for the investigation of eminent bioactive constituents may serve as an alternative candidate against Alzheimer’s disease and other neurodegenerative disorders.

Cite this article as:

Pradhan K. Anil, Tripathy Bimala*, Chowdhury Bimalendu, Acharjya K. Sasmita and Das Rajaram, Current Pathogenesis of Alzheimer’s Disease and Plants Derived Neuroprotective Phytoconstituents: A Comprehensive Review, Current Psychopharmacology 2021; 10 (3) : e280721195076 . https://dx.doi.org/10.2174/2211556010666210728123937