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Current Drug Safety

Editor-in-Chief

ISSN (Print): 1574-8863
ISSN (Online): 2212-3911

Case Report

Isolated Tongue Angioedema after Alteplase Infusion in Acute Ischemic Stroke

Author(s): Ermanno Pisani, Carmen Gaudiano, Alfredo Petrone, Furio Stancati and Antonio Siniscalchi*

Volume 17, Issue 1, 2022

Published on: 28 July, 2021

Page: [75 - 77] Pages: 3

DOI: 10.2174/1574886316666210728104331

Price: $65

Abstract

Background: Angioedema, like anaphylaxis, has been reported as a rare adverse event of alteplase infusion in acute ischemic stroke.

Objective: We report the case of a patient with acute ischemic stroke who, after treatment of alteplase, developed angioedema.

Methods: We report the case of an 81-year-old woman who presented to our observation with acute ischemic stroke. The patient was on therapy with 100 mg acetylsalicylic acid and a triple combination antihypertensive drug (perindopril 10 mg + 2.5 mg indapamide + 5 mg amlodipine). The patient was treated with alteplase infusion.

Results: Five minutes after the end of the alteplase infusion (0.9 mg/kg for 1 hour), the patient developed isolated angioedema of the lips and tongue.

Conclusion: Although the incidence of alteplase-induced angioedema in these patients is rare, this case report suggests the need for a routine inspection of the tongue in an acute ischemic patient in treatment with alteplase infusion, especially in female patients in treatment with ACE inhibitors.

Keywords: ACE inhibitor, acute ischemic stroke, angioedema, alteplase, woman, alteplase infusion.

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