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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Synthesis and Development of Indole Based 5-HT3 Receptor Antagonists as Anti-Emetic Drugs in Oncology: An Update

Author(s): Johana L. Rivera-Fonseca, Nelly González-Rivas, M. V. Basavanag Unnamatla, Marco A. García-Eleno, Horacio Reyes, L. Germán López-Valdez, David Corona-Becerril and Erick Cuevas-Yañez*

Volume 28, Issue 42, 2021

Published on: 08 July, 2021

Page: [8733 - 8754] Pages: 22

DOI: 10.2174/0929867328666210708091134

Price: $65

Abstract

An important group of antiemetic drugs used in the treatment of nausea and vomiting after chemotherapy containing an indole moiety in their structures, working as 5- hydroxytryptamine type 3 serotonin receptor antagonist (5-HT3). This study focuses on compounds bearing an indole core that present a 5-HT3 receptor antagonist activity, which have been successfully used as antiemetic drugs for reducing chemotherapy adverse secondary effects during cancer treatment. Their synthesis, biological activities, and some outstanding characteristics are discussed, providing a general outlook towards the development of more efficient antiemetic drugs.

Keywords: Antiemetic drugs, 5-HT3, indole, synthesis, ondansetron, ramosetron, dolasetron, granisetron, ricasetron, tropisetron.


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