Abstract
Recent advances in the metal-catalyzed hydrofunctionalization of alkynes with carboxylic acids are comprehensively reviewed. Both inter- and intramolecular processes, leading respectively to enol esters and lactones, are discussed, as well as the involvement of these transformations in the synthesis of natural products and biologically active molecules, and the assembly of elaborated heterocyclic compounds through cascade processes. Literature published since 2011 is covered.
Keywords: Enol esters, lactones, alkynes, hydro-oxycarbonylation reactions, cycloisomerization reactions, metal-catalyzed transformations.
Graphical Abstract
Current Organic Chemistry
Title:Recent Advances in the Transition Metal-Catalyzed Addition of Carboxylic Acids to Alkynes
Volume: 25 Issue: 20
Author(s): Victorio Cadierno*
Affiliation:
- Departamento de Quimica Organica e Inorganica, Facultad de Quimica, Universidad de Oviedo, E-33006 Oviedo,Spain
Keywords: Enol esters, lactones, alkynes, hydro-oxycarbonylation reactions, cycloisomerization reactions, metal-catalyzed transformations.
Abstract: Recent advances in the metal-catalyzed hydrofunctionalization of alkynes with carboxylic acids are comprehensively reviewed. Both inter- and intramolecular processes, leading respectively to enol esters and lactones, are discussed, as well as the involvement of these transformations in the synthesis of natural products and biologically active molecules, and the assembly of elaborated heterocyclic compounds through cascade processes. Literature published since 2011 is covered.
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Cite this article as:
Cadierno Victorio *, Recent Advances in the Transition Metal-Catalyzed Addition of Carboxylic Acids to Alkynes, Current Organic Chemistry 2021; 25 (20) . https://dx.doi.org/10.2174/1385272825666210308113837
DOI https://dx.doi.org/10.2174/1385272825666210308113837 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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