Novel Nitrogen Containing Steroid Derivatives for Prostate Cancer Treatment

Title:Novel Nitrogen Containing Steroid Derivatives for Prostate Cancer Treatment

Volume: 28 Issue: 40

Author(s): Alexandra S. Latysheva, Vladimir A. Zolottsev, Vadim S. Pokrovsky*, Irina I. Khan and Alexander Yu. Misharin

Affiliation:

• N.N. Blokhin National Medical Research Center of Oncology of Ministry of Health of Russian Federation, 24, Kashirskoye highway, 115478 Moscow,Russian Federation

Keywords: Prostate cancer, steroid CYP17A1 inhibitors, abiraterone, galeterone, novel nitrogen, anti-prostate cancer agents, androgen deprivation therapy.

Abstract: This mini-review focuses on the investigation of novel nitrogen-containing steroid derivatives that are potentially applicable for prostate cancer treatment. It covers the literature of the last decade, highlighting the structure of new steroid compounds that exhibit significant activity in prostate cancer cells and possess pharmacological potency. New derivatives of known anti-prostate cancer agents: abiraterone and galeterone, new derivatives of androstane and pregnane modified with nitrogen-containing heterocycles, and some related steroid-derived compounds are discussed in the review.

Cite this article as:

Latysheva S. Alexandra, Zolottsev A. Vladimir , Pokrovsky S. Vadim *, Khan I. Irina and Misharin Yu. Alexander , Novel Nitrogen Containing Steroid Derivatives for Prostate Cancer Treatment, Current Medicinal Chemistry 2021; 28 (40) . https://dx.doi.org/10.2174/0929867328666210208113919