Login Register Cart 0
Generic placeholder image

Endocrine, Metabolic & Immune Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Thyroid Diseases During Pregnancy: Bibliometric Analysis of Scientific Publications

Author(s): Ning Yuan, Li Wang, Zhi Li and Xiaomei Zhang*

Volume 22, Issue 2, 2022

Published on: 03 February, 2021

Page: [247 - 258] Pages: 12

DOI: 10.2174/1871530321666210203214142

Price: $65

Abstract

Background: Bibliometric analysis can analyze development trends and predict research hotspots. We used these analyses to better understand the pregnancy-related implications of thyroid diseases.

Methods: Publications on thyroid diseases during pregnancy from 1926 to hitherto were retrieved based on the Web of Science database. The publications and references, the institutions and countries, the journals, the keywords and citations were analyzed by utilizing VOSviewer, CiteSpace and Cit- NetExplorer.

Results: A total of 3310 publications were retrieved and were cited 87913 times. The United States took the dominant position in outputs and collaborations. Harvard University had the most articles 86, which also had the highest h-index 30. Thyroid ranked first with 201 publications and Journal of Clinical Endocrinology Metabolism had the highest h-index 67. Among the 49 burst keywords, "antibody" had the longest burst period from 1991 to 2012, "thyroxine" had the strongest burst strength 16.7026, "hypothyroxinemia" appeared most recently in 2018. The most frequent keyword was "pregnancy" which occurred 1324 times. All the top 98 frequent keywords were clustered into 4 clusters. The citation network visualization was grouped into 8 groups.

Conclusion: The research focus of thyroid diseases in pregnancy ranged from clinical thyroid dysfunction to milder thyroid dysfunction. Guidelines published by the American Thyroid Association enacted a crucial purpose in the treatment and development of thyroid diseases during pregnancy. Some randomized controlled studies of unresolved problems and long-term follow-up of offspring may be the direction of future research. In the meantime, bibliometric methods can help scholars choose journals, track research hotspots, and identify the direction or focus of future research.

Keywords: Thyroid diseases, pregnancy, maternal, bibliometrics, guideline, outcomes.

« Previous
Graphical Abstract

[1]
Korevaar, T.I.M.; Medici, M.; Visser, T.J.; Peeters, R.P. Thyroid disease in pregnancy: new insights in diagnosis and clinical management. Nat. Rev. Endocrinol., 2017, 13(10), 610-622.
[http://dx.doi.org/10.1038/nrendo.2017.93] [PMID: 28776582]
[2]
Nathan, N.; Sullivan, S.D. Thyroid disorders during pregnancy. Endocrinol. Metab. Clin. North Am., 2014, 43(2), 573-597.
[http://dx.doi.org/10.1016/j.ecl.2014.02.008] [PMID: 24891179]
[3]
Stagnaro-Green, A.; Abalovich, M.; Alexander, E.; Azizi, F.; Mestman, J.; Negro, R.; Nixon, A.; Pearce, E.N.; Soldin, O.P.; Sullivan, S.; Wiersinga, W. American Thyroid Association Taskforce on Thyroid Disease During Pregnancy and Postpartum. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid, 2011, 21(10), 1081-1125.
[http://dx.doi.org/10.1089/thy.2011.0087] [PMID: 21787128]
[4]
De Groot, L.; Abalovich, M.; Alexander, E.K.; Amino, N.; Barbour, L.; Cobin, R.H.; Eastman, C.J.; Lazarus, J.H.; Luton, D.; Mandel, S.J.; Mestman, J.; Rovet, J.; Sullivan, S. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab., 2012, 97(8), 2543-2565.
[http://dx.doi.org/10.1210/jc.2011-2803] [PMID: 22869843]
[5]
Alexander, E.K.; Pearce, E.N.; Brent, G.A.; Brown, R.S.; Chen, H.; Dosiou, C.; Grobman, W.A.; Laurberg, P.; Lazarus, J.H.; Mandel, S.J.; Peeters, R.P.; Sullivan, S. 2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum. Thyroid, 2017, 27(3), 315-389.
[http://dx.doi.org/10.1089/thy.2016.0457] [PMID: 28056690]
[6]
Korevaar, T.I.M.; Derakhshan, A.; Taylor, P.N.; Meima, M.; Chen, L.; Bliddal, S.; Carty, D.M.; Meems, M.; Vaidya, B.; Shields, B.; Ghafoor, F.; Popova, P.V.; Mosso, L.; Oken, E.; Suvanto, E.; Hisada, A.; Yoshinaga, J.; Brown, S.J.; Bassols, J.; Auvinen, J.; Bramer, W.M.; López-Bermejo, A.; Dayan, C.; Boucai, L.; Vafeiadi, M.; Grineva, E.N.; Tkachuck, A.S.; Pop, V.J.M.; Vrijkotte, T.G.; Guxens, M.; Chatzi, L.; Sunyer, J.; Jiménez-Zabala, A.; Riaño, I.; Murcia, M.; Lu, X.; Mukhtar, S.; Delles, C.; Feldt-Rasmussen, U.; Nelson, S.M.; Alexander, E.K.; Chaker, L.; Männistö, T.; Walsh, J.P.; Pearce, E.N.; Steegers, E.A.P.; Peeters, R.P. Consortium on Thyroid and Pregnancy—Study Group on Preterm Birth. Association of Thyroid Function Test Abnormalities and Thyroid Autoimmunity With Preterm Birth: A Systematic Review and Meta-analysis. JAMA, 2019, 322(7), 632-641.
[http://dx.doi.org/10.1001/jama.2019.10931] [PMID: 31429897]
[7]
Carlé, A.; Knudsen, N.; Jørgensen, T.; Thuesen, B.; Karmisholt, J.; Linding Andersen, S.; Bülow Pedersen, I. Previous Live Births and Induced Abortions May Precede Later Development of Graves’. Hyperthyroidism. Eur. Thyroid J., 2019, 8(2), 70-78.
[http://dx.doi.org/10.1159/000494836] [PMID: 31192145]
[8]
Falagas, M.E.; Pitsouni, E.I.; Malietzis, G.A.; Pappas, G. Comparison of PubMed, Scopus, Web of Science, and Google Scholar: strengths and weaknesses. FASEB J., 2008, 22(2), 338-342.
[http://dx.doi.org/10.1096/fj.07-9492LSF] [PMID: 17884971]
[9]
van Eck, N.J.; Waltman, L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics, 2010, 84(2), 523-538.
[http://dx.doi.org/10.1007/s11192-009-0146-3] [PMID: 20585380]
[10]
Synnestvedt, M.B.; Chen, C.; Holmes, J.H. CiteSpace II: visualization and knowledge discovery in bibliographic databases; JASIST, 2005, pp. 724-728.
[11]
van Eck, N.J.; Waltman, L. CitNetExplorer: A new software tool for analyzing and visualizing citation networks. J. Informetrics, 2014, 8(4), 802-823.
[http://dx.doi.org/10.1016/j.joi.2014.07.006]
[12]
Abalovich, M.; Amino, N.; Barbour, L.A.; Cobin, R.H.; De Groot, L.J.; Glinoer, D.; Mandel, S.J.; Stagnaro-Green, A. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society Clinical Practice Guideline. J. Clin. Endocrinol. Metab., 2007, 92(8)(Suppl.), S1-S47.
[http://dx.doi.org/10.1210/jc.2007-0141] [PMID: 17948378]
[13]
Li, C.; Peng, S.; Zhang, X.; Xie, X.; Wang, D.; Mao, J.; Teng, X.; Shan, Z.; Teng, W. The Urine Iodine to Creatinine as an Optimal Index of Iodine During Pregnancy in an Iodine Adequate Area in China. J. Clin. Endocrinol. Metab., 2016, 101(3), 1290-1298.
[http://dx.doi.org/10.1210/jc.2015-3519] [PMID: 26789777]
[14]
Xiao, Y.; Sun, H.; Li, C.; Li, Y.; Peng, S.; Fan, C.; Teng, W.; Shan, Z. Effect of Iodine Nutrition on Pregnancy Outcomes in an Iodine-Sufficient Area in China. Biol. Trace Elem. Res., 2018, 182(2), 231-237.
[http://dx.doi.org/10.1007/s12011-017-1101-4] [PMID: 28770411]
[15]
Teng, X.; Shan, Z.; Li, C.; Yu, X.; Mao, J.; Wang, W.; Xie, X.; Du, J.; Zhang, S.; Gao, Z.; Zhang, X.; Li, L.; Fan, C.; Teng, W. Iron Deficiency May Predict Greater Risk for Hypothyroxinemia: A Retrospective Cohort Study of Pregnant Women in China. Thyroid, 2018, 28(8), 968-975.
[http://dx.doi.org/10.1089/thy.2017.0491] [PMID: 29968513]
[16]
Kahaly, G.J.; Bartalena, L.; Hegedüs, L.; Leenhardt, L.; Poppe, K.; Pearce, S.H. 2018 European Thyroid Association Guideline for the Management of Graves’. Hyperthyroidism. Eur. Thyroid J., 2018, 7(4), 167-186.
[http://dx.doi.org/10.1159/000490384] [PMID: 30283735]
[17]
Muller, I.; Moran, C.; Lecumberri, B.; Decallonne, B.; Robertson, N.; Jones, J.; Dayan, C.M. 2019 European Thyroid Association Guidelines on the Management of Thyroid Dysfunction following Immune Reconstitution Therapy. Eur. Thyroid J., 2019, 8(4), 173-185.
[http://dx.doi.org/10.1159/000500881] [PMID: 31602359]
[18]
Zhou, H.; Tan, W.; Qiu, Z.; Song, Y.; Gao, S. A bibliometric analysis in gene research of myocardial infarction from 2001 to 2015. PeerJ, 2018, 6e4354.
[http://dx.doi.org/10.7717/peerj.4354] [PMID: 29456889]
[19]
Zou, L.X.; Sun, L. Global diabetic kidney disease research from 2000 to 2017: A bibliometric analysis. Medicine (Baltimore), 2019, 98(6)e14394
[http://dx.doi.org/10.1097/MD.0000000000014394] [PMID: 30732183]
[20]
Goodwin, T.M.; Montoro, M.; Mestman, J.H. Transient hyperthyroidism and hyperemesis gravidarum: clinical aspects. Am. J. Obstet. Gynecol., 1992, 167(3), 648-652.
[http://dx.doi.org/10.1016/S0002-9378(11)91565-8] [PMID: 1382389]
[21]
Skuza, K.A.; Sills, I.N.; Stene, M.; Rapaport, R. Prediction of neonatal hyperthyroidism in infants born to mothers with Graves disease. J. Pediatr., 1996, 128(2), 264-268.
[http://dx.doi.org/10.1016/S0022-3476(96)70405-5] [PMID: 8636826]
[22]
Wasserstrum, N.; Anania, C.A. Perinatal consequences of maternal hypothyroidism in early pregnancy and inadequate replacement. Clin. Endocrinol. (Oxf.), 1995, 42(4), 353-358.
[http://dx.doi.org/10.1111/j.1365-2265.1995.tb02642.x] [PMID: 7750188]
[23]
Haddow, J.E.; Palomaki, G.E.; Allan, W.C.; Williams, J.R.; Knight, G.J.; Gagnon, J.; O’Heir, C.E.; Mitchell, M.L.; Hermos, R.J.; Waisbren, S.E.; Faix, J.D.; Klein, R.Z. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N. Engl. J. Med., 1999, 341(8), 549-555.
[http://dx.doi.org/10.1056/NEJM199908193410801] [PMID: 10451459]
[24]
Parkes, A.B.; Othman, S.; Hall, R.; John, R.; Lazarus, J.H. Role of complement in the pathogenesis of postpartum thyroiditis: relationship between complement activation and disease presentation and progression. Eur. J. Endocrinol., 1995, 133(2), 210-215.
[http://dx.doi.org/10.1530/eje.0.1330210] [PMID: 7655646]
[25]
Lucas, A.; Pizarro, E.; Granada, M.L.; Salinas, I.; Foz, M.; Sanmarti, A. Postpartum thyroiditis: epidemiology and clinical evolution in a nonselected population. Thyroid, 2000, 10(1), 71-77.
[http://dx.doi.org/10.1089/thy.2000.10.71] [PMID: 10691316]
[26]
Wier, F.A.; Farley, C.L. Clinical controversies in screening women for thyroid disorders during pregnancy. J. Midwifery Womens Health, 2006, 51(3), 152-158.
[http://dx.doi.org/10.1016/j.jmwh.2005.11.007] [PMID: 16647667]
[27]
Pop, V.J.; Brouwers, E.P.; Vader, H.L.; Vulsma, T.; van Baar, A.L.; de Vijlder, J.J. Maternal hypothyroxinaemia during early pregnancy and subsequent child development: a 3-year follow-up study. Clin. Endocrinol. (Oxf.), 2003, 59(3), 282-288.
[http://dx.doi.org/10.1046/j.1365-2265.2003.01822.x] [PMID: 12919150]
[28]
Román, G.C. Autism: transient in utero hypothyroxinemia related to maternal flavonoid ingestion during pregnancy and to other environmental antithyroid agents. J. Neurol. Sci., 2007, 262(1-2), 15-26.
[http://dx.doi.org/10.1016/j.jns.2007.06.023] [PMID: 17651757]
[29]
Casey, B.M.; Dashe, J.S.; Spong, C.Y.; McIntire, D.D.; Leveno, K.J.; Cunningham, G.F. Perinatal significance of isolated maternal hypothyroxinemia identified in the first half of pregnancy. Obstet. Gynecol., 2007, 109(5), 1129-1135.
[http://dx.doi.org/10.1097/01.AOG.0000262054.03531.24] [PMID: 17470594]
[30]
Korada, M.; Pearce, M.S.; Avis, E.; Turner, S.; Cheetham, T. TSH levels in relation to gestation, birth weight and sex. Horm. Res., 2009, 72(2), 120-123.
[http://dx.doi.org/10.1159/000232165] [PMID: 19690430]
[31]
Phoojaroenchanachai, M.; Sriussadaporn, S.; Peerapatdit, T.; Vannasaeng, S.; Nitiyanant, W.; Boonnamsiri, V.; Vichayanrat, A. Effect of maternal hyperthyroidism during late pregnancy on the risk of neonatal low birth weight. Clin. Endocrinol. (Oxf.), 2001, 54(3), 365-370.
[http://dx.doi.org/10.1046/j.1365-2265.2001.01224.x] [PMID: 11298089]
[32]
Alvarez-Pedrerol, M.; Guxens, M.; Mendez, M.; Canet, Y.; Martorell, R.; Espada, M.; Plana, E.; Rebagliato, M.; Sunyer, J. Iodine levels and thyroid hormones in healthy pregnant women and birth weight of their offspring. Eur. J. Endocrinol., 2009, 160(3), 423-429.
[http://dx.doi.org/10.1530/EJE-08-0716] [PMID: 19114540]
[33]
Wu, M.Q.; Liu, J.; Wang, Y.Q.; Yang, Y.; Yan, C.H.; Hua, J. The Impact of Subclinical Hypothyroidism on Adverse Perinatal Outcomes and the Role of Thyroid Screening in Pregnancy. Front. Endocrinol. (Lausanne), 2019, 10, 522.
[http://dx.doi.org/10.3389/fendo.2019.00522] [PMID: 31447778]
[34]
Maraka, S.; Mwangi, R.; McCoy, R.G.; Yao, X.; Sangaralingham, L.R.; Singh Ospina, N.M.; O’Keeffe, D.T.; De Ycaza, A.E.; Rodriguez-Gutierrez, R.; Coddington, C.C., III; Stan, M.N.; Brito, J.P.; Montori, V.M. Thyroid hormone treatment among pregnant women with subclinical hypothyroidism: US national assessment. BMJ, 2017, 356, i6865.
[http://dx.doi.org/10.1136/bmj.i6865] [PMID: 28122781]
[35]
Abel, M.H.; Caspersen, I.H.; Meltzer, H.M.; Haugen, M.; Brandlistuen, R.E.; Aase, H.; Alexander, J.; Torheim, L.E.; Brantsæter, A.L. Suboptimal Maternal Iodine Intake Is Associated with Impaired Child Neurodevelopment at 3 Years of Age in the Norwegian Mother and Child Cohort Study. J. Nutr., 2017, 147(7), 1314-1324.
[http://dx.doi.org/10.3945/jn.117.250456] [PMID: 28515161]
[36]
Zhang, Y.; Fan, Y.; Yu, X.; Wang, X.; Bao, S.; Li, J.; Fan, C.; Shan, Z.; Teng, W. Maternal Subclinical Hypothyroidism Impairs Neurodevelopment in Rat Offspring by Inhibiting the CREB Signaling Pathway. Mol. Neurobiol., 2015, 52(1), 432-441.
[http://dx.doi.org/10.1007/s12035-014-8855-x] [PMID: 25193019]
[37]
Liu, H.; Shan, Z.; Li, C.; Mao, J.; Xie, X.; Wang, W.; Fan, C.; Wang, H.; Zhang, H.; Han, C.; Wang, X.; Liu, X.; Fan, Y.; Bao, S.; Teng, W. Maternal subclinical hypothyroidism, thyroid autoimmunity, and the risk of miscarriage: a prospective cohort study. Thyroid, 2014, 24(11), 1642-1649.
[http://dx.doi.org/10.1089/thy.2014.0029] [PMID: 25087688]
[38]
Mosaddegh, M.H.; Ghasemi, N.; Jahaninejad, T.; Mohsenifar, F.; Aflatoonian, A. Treatment of recurrent pregnancy loss by Levothyroxine in women with high Anti-TPO antibody. Iran. J. Reprod. Med., 2012, 10(4), 373-376.
[PMID: 25246900]
[39]
Yang, Y.; Li, Q.; Wang, Q.; Ma, X. Thyroid antibodies and gestational diabetes mellitus: a meta-analysis. Fertil. Steril., 2015, 104(3), 665-71.e3.
[http://dx.doi.org/10.1016/j.fertnstert.2015.06.003] [PMID: 26151621]
[40]
Zhang, F.; Chen, J.; Lin, X.; Peng, S.; Yu, X.; Shan, Z.; Teng, W. Subclinical hypothyroidism in pregnant rats impaired learning and memory of their offspring by promoting the p75NTR signal pathway. Endocr. Connect., 2018, 7(5), 688-697.
[http://dx.doi.org/10.1530/EC-18-0069] [PMID: 29669804]
[41]
Thompson, W.; Russell, G.; Baragwanath, G.; Matthews, J.; Vaidya, B.; Thompson-Coon, J. Maternal thyroid hormone insufficiency during pregnancy and risk of neurodevelopmental disorders in offspring: A systematic review and meta-analysis. Clin. Endocrinol. (Oxf.), 2018, 88(4), 575-584.
[http://dx.doi.org/10.1111/cen.13550] [PMID: 29325223]
[42]
Zhang, Y.; Wang, H.; Pan, X.; Teng, W.; Shan, Z. Patients with subclinical hypothyroidism before 20 weeks of pregnancy have a higher risk of miscarriage: A systematic review and meta-analysis. PLoS One, 2017, 12(4)e0175708
[http://dx.doi.org/10.1371/journal.pone.0175708] [PMID: 28414788]
[43]
Stagnaro-Green, A.; Abalovich, M.; Alexander, E.; Azizi, F.; Mestman, J.; Negro, R.; Nixon, A.; Pearce, E.N.; Soldin, O.P.; Sullivan, S.; Wiersinga, W. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid : official journal of the American Thyroid Association, 2011, 21, 1081-1125.
[44]
Korevaar, T.I.; Medici, M.; de Rijke, Y.B.; Visser, W.; de Muinck Keizer-Schrama, S.M.; Jaddoe, V.W.; Hofman, A.; Ross, H.A.; Visser, W.E.; Hooijkaas, H.; Steegers, E.A.; Tiemeier, H.; Bongers-Schokking, J.J.; Visser, T.J.; Peeters, R.P. Ethnic differences in maternal thyroid parameters during pregnancy: the Generation R study. J. Clin. Endocrinol. Metab., 2013, 98(9), 3678-3686.
[http://dx.doi.org/10.1210/jc.2013-2005] [PMID: 23836936]
[45]
Shen, F.X.; Xie, Z.W.; Lu, S.M.; Aw, T.C.; Zhu, B. Gestational thyroid reference intervals in antibody-negative Chinese women. Clin. Biochem., 2014, 47(7-8), 673-675.
[http://dx.doi.org/10.1016/j.clinbiochem.2014.02.023] [PMID: 24631176]
[46]
Yan, Y.Q.; Dong, Z.L.; Dong, L.; Wang, F.R.; Yang, X.M.; Jin, X.Y.; Lin, L.X.; Sun, Y.N.; Chen, Z.P. Trimester- and method-specific reference intervals for thyroid tests in pregnant Chinese women: methodology, euthyroid definition and iodine status can influence the setting of reference intervals. Clin. Endocrinol. (Oxf.), 2011, 74(2), 262-269.
[http://dx.doi.org/10.1111/j.1365-2265.2010.03910.x] [PMID: 21044115]
[47]
Levie, D.; Derakhshan, A.; Shu, H.; Broeren, M.A.C.; de Poortere, R.A.; Peeters, R.P.; Bornehag, C.G.; Demeneix, B.; Korevaar, T.I.M. The Association of Maternal Iodine Status in Early Pregnancy with Thyroid Function in the Swedish Environmental Longitudinal, Mother and Child, Asthma and Allergy Study. Thyroid : official journal of the American Thyroid Association, 2019, 29(11), 1660-1668.
[48]
Yang, J.; Liu, Y.; Liu, H.; Zheng, H.; Li, X.; Zhu, L.; Wang, Z. Associations of maternal iodine status and thyroid function with adverse pregnancy outcomes in Henan Province of China. J. Trace Elem. Med. Biol., 2018, 47, 104-110.
[http://dx.doi.org/10.1016/j.jtemb.2018.01.013] [PMID: 29544795]
[49]
Bath, S.C.; Steer, C.D.; Golding, J.; Emmett, P.; Rayman, M.P. Effect of inadequate iodine status in UK pregnant women on cognitive outcomes in their children: results from the Avon Longitudinal Study of Parents and Children (ALSPAC). Lancet, 2013, 382(9889), 331-337.
[http://dx.doi.org/10.1016/S0140-6736(13)60436-5] [PMID: 23706508]
[50]
Millar, L.K.; Wing, D.A.; Leung, A.S.; Koonings, P.P.; Montoro, M.N.; Mestman, J.H. Low birth weight and preeclampsia in pregnancies complicated by hyperthyroidism. Obstet. Gynecol., 1994, 84(6), 946-949.
[PMID: 7970474]

Rights & Permissions Print Cite
Article Metrics
49
1
© 2024 Bentham Science Publishers | Privacy Policy