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Current Drug Discovery Technologies

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ISSN (Print): 1570-1638
ISSN (Online): 1875-6220

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Review Article

Prunella vulgaris L: Critical Pharmacological, Expository Traditional Uses and Extensive Phytochemistry: A Review

Author(s): Reyaz Hassan Mir*, Mohammad Faizan Bhat, Gifty Sawhney, Parveen Kumar, Nusrit Iqbal Andrabi, Majeed Shaikh, Roohi Mohi-ud-Din and Mubashir Hussain Masoodi*

Volume 19, Issue 1, 2022

Published on: 03 February, 2021

Article ID: e140122191102 Pages: 13

DOI: 10.2174/1570163818666210203181542

Price: $65

Abstract

Background: Prunella vulgaris , family Lamiaceae also known as self-heal, has been traditionally used as an expectorant, anti-inflammatory, anti-pyretic, and anti-rheumatic. Due to the widespread distribution of the plant, Vulgaris is also called ‘vulgar’ in Latin adjective meaning common.

Objective: The objective of this review was to describe the relevant aspects of phytochemistry and therapeutic uses of different fractions as well as isolated compounds from Prunella vulgaris . An attempt was also made to enumerate the possible leads, e.g . betulinic acid, oleanolic acid, ursolic acid, umbelliferone, scopoletin, esculetin, luteolin, homoorientin, Rosmarinic acid and cinaroside, for further development.

Method: For peer-reviewed research literature, we undertook a structured search of bibliographic databases using a focused review question. Scientific databases such as PubMed, Scopus, Science Direct, and Google Scholar were searched.

Results: Phytochemistry of Prunella vulgaris (PV) after a thorough literature survey revealed varied and copious metabolites, such as triterpenoids, phenolic acid, sterols, carbohydrates, coumarins, fatty acids, and volatile oils. Many of these compounds have been found to possess a wide range of biological activities per se, including anti-microbial, immunosuppressive, anti-cancer, cardio- protective, anti-allergic and anti-inflammatory activities.

Conclusion: Prunella vulgaris is a medicinal plant of immense medicinal importance having a variety of compounds, such as triterpenoids, phenolic acid, sterols, carbohydrates, coumarins, fatty acids, and volatile oils, and diversity in the pharmacological spectrum. The plant could be further exploited to isolate the various biologically active constituents responsible for its activity.

Keywords: Prunella vulgaris, phytochemistry, cytotoxicity, antimicrobial, immunosuppressive, anticancer, cardioprotective.

Graphical Abstract

[1]
Extracts H. WOUND ROOT 2015. Available from: http://www.herbalextracts plus.com/wound-root.html
[2]
Markova H, Sousek J, Ulrichova J. Prunella vulgaris L.--a rediscovered medicinal plant. Ceska a Slovenska farmacie: casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 1997; 46(2): 58-63..
[3]
Khalid A, et al. Antibacterial activity analysis of extracts of various plants against gram-positive and-negative bacteria. Afr J Pharm Pharmacol 2011; 5(7): 887-93.
[4]
Jackson D, Bergeron K. Plant profile of Prunella vulgaris L 2006.
[5]
Blake SF, Atwood AC. Geographical guide to floras of the world: Miscellenious Publication, Washington D.C.. US Government Printing Office 1961. pp. 420-41.
[6]
Chattopadhyay D, Sarkar MC, Chatterjee T, et al. Recent advancements for the evaluation of anti-viral activities of natural products. N Biotechnol 2009; 25(5): 347-68.
[http://dx.doi.org/10.1016/j.nbt.2009.03.007] [PMID: 19464980]
[7]
Xu H-X, Lee SH, Lee SF, White RL, Blay J. Isolation and characterization of an anti-HSV polysaccharide from Prunella vulgaris. Antiviral Res 1999; 44(1): 43-54.
[http://dx.doi.org/10.1016/S0166-3542(99)00053-4] [PMID: 10588332]
[8]
Fang X, Yu MM, Yuen WH, Zee SY, Chang RC. Immune modulatory effects of Prunella vulgaris L. on monocytes/macrophages. Int J Mol Med 2005; 16(6): 1109-16.
[http://dx.doi.org/10.3892/ijmm.16.6.1109] [PMID: 16273294]
[9]
Zhang G, He L, Hu M. Optimized ultrasonic-assisted extraction of flavonoids from Prunella vulgaris L. and evaluation of antioxidant activities in vitro. Innov Food Sci Emerg Technol 2011; 12(1): 18-25.
[http://dx.doi.org/10.1016/j.ifset.2010.12.003]
[10]
Koh H-L, Woo S-O. Chinese proprietary medicine in Singapore: regulatory control of toxic heavy metals and undeclared drugs. Drug Saf 2000; 23(5): 351-62.
[http://dx.doi.org/10.2165/00002018-200023050-00001] [PMID: 11085343]
[11]
Duke J, Ayensu E. Medicinal plants of China. Reference PublReview by Prance, GT in Brittonia Algonac, USA 1985; vol 2(670): 37-194.
[12]
Foster S, Duke JA. A field guide to medicinal plants: eastern and central North America 1990; Vol. 395353092.: 366. ISBN.
[13]
Chauhan NS. Medicinal and aromatic plants of Himachal Pradesh. Indus Publishing 1999.
[14]
Pui-hay BP, Hson-mou C. Pharmacology and applications of Chinese materia medica. World Scientific 1987; Vol. 1; pp779-786.
[15]
Goldschmidt A. The evolution of Chinese medicine: Song dynasty, 960–1200
[http://dx.doi.org/10.4324/9780203946435]
[16]
Qureshi NA, Ali GI, Abushanab TS, et al. History of cupping (Hijama): a narrative review of literature. J Integr Med 2017; 15(3): 172-81.
[http://dx.doi.org/10.1016/S2095-4964(17)60339-X] [PMID: 28494847]
[17]
Du H, Kuang TT, Qiu S, et al. Fecal medicines used in traditional medical system of China: a systematic review of their names, original species, traditional uses, and modern investigations. Chin Med 2019; 14(1): 31.
[http://dx.doi.org/10.1186/s13020-019-0253-x] [PMID: 31528199]
[18]
Yao X-J, Wainberg MA, Parniak MA. Mechanism of inhibition of HIV-1 infection in vitro by purified extract of Prunella vulgaris. Virology 1992; 187(1): 56-62.
[http://dx.doi.org/10.1016/0042-6822(92)90294-Y] [PMID: 1371029]
[19]
Bai Y, Xia B, Xie W, et al. Phytochemistry and pharmacological activities of the genus Prunella. Food Chem 2016; 204: 483-96.
[http://dx.doi.org/10.1016/j.foodchem.2016.02.047] [PMID: 26988527]
[20]
Wang S-J, Wang XH, Dai YY, et al. Prunella vulgaris: A Comprehensive Review of Chemical Constituents, Pharmacological Effects and Clinical Applications. Curr Pharm Des 2019; 25(3): 359-69.
[http://dx.doi.org/10.2174/1381612825666190313121608] [PMID: 30864498]
[21]
Wang ZJ, Zhao YY, Chen YY, Ma BN. [Triterpenoid compounds of Prunella genus and their features of 13C NMR spectroscopy]. Zhongguo Zhongyao Zazhi 2000; 25(10): 583-8.
[PMID: 12516447]
[22]
CAI, Z.-q., H.-y. MA, and M. ZHANG. Content analysis of oleanolic acid and ursolic acid in Prunella vulgaris based on its provenances and appearances [J]. J Guangdong Pharmaceutical College 2009; 3: 010..
[23]
Sun Y, et al. Determination of Ursolic Acid in Prunella vulgaris from Different Areas by HPLC. Shizhen Guoyi Guoyao 2009; 20: 1125-6.
[24]
Kojima H, Ogura H. Triterpenoids from Prunella vulgaris. Phytochemistry 1986; 25(3): 729-33.
[http://dx.doi.org/10.1016/0031-9422(86)88033-5]
[25]
Kojima H, et al. Two novel hexacyclic triterpenoids from Prunella vulgaris. Phytochemistry 1988; 27(9): 2921-5.
[http://dx.doi.org/10.1016/0031-9422(88)80689-7]
[26]
Şahin S, Demir C, Malyer H. Determination of phenolic compounds in Prunella L. by liquid chromatography-diode array detection. J Pharm Biomed Anal 2011; 55(5): 1227-30.
[http://dx.doi.org/10.1016/j.jpba.2011.03.016] [PMID: 21498022]
[27]
Şahin S, Ari F, Demir C, Ulukaya E. Isolation of Major Phenolic Compounds from the Extracts of P runella L. Species Grown in T urkey and Their Antioxidant and Cytotoxic Activities. J Food Biochem 2014; 38(2): 248-57.
[http://dx.doi.org/10.1111/jfbc.12043]
[28]
Kojima H, Sato N, Hatano A, Ogura H. Pentacyclic triterpenoids from Prunella vulgaris. Phytochemistry 1987; 26(4): 1107-11.
[http://dx.doi.org/10.1016/S0031-9422(00)82359-6]
[29]
Kojima H, Sato N, Hatano A, Ogura H. Sterol glucosides from Prunella vulgaris. Phytochemistry 1990; 29(7): 2351-5.
[http://dx.doi.org/10.1016/0031-9422(90)83073-A]
[30]
Zhengmu M, Liwen H. Studies on Constituents of Prunella vulgaris L. Zhongguo Yaoke Daxue Xuebao 1995; 6.
[31]
Meng G, Wang M, Zhang K, Guo Z, Shi J. Research progress on the chemistry and pharmacology of Prunella vulgaris species. Open Access Library Journal 2014; 1(03): 1.
[http://dx.doi.org/10.4236/oalib.1100558]
[32]
Wang Z. Studies on the chemical constituents from Prunella vulgaris. Yao Xue Xue Bao 1999; 34: 679-81.
[33]
Hu X, Cui S, Chen X, Hu Z. CE with field-enhanced stacking for rapid and sensitive determination of umbelliferone, rutin and aesculetin in Prunella vulgaris. Chromatographia 2009; 70(11-12): 1733.
[http://dx.doi.org/10.1365/s10337-009-1373-8]
[34]
Jozef S. Phytochemical Studies on Prunella vulgaris and Prunella Grandiflora Saponin and Triterpene Compounds. Dissertations Pharm 1963; 15: 333-3.
[35]
Zhang L-Z, Guo YJ, Tu GZ, et al. A novel triterpenoid saponin from Prunella vulgaris. Yao Xue Xue Bao 2008; 43(2): 169-72.
[PMID: 18507344]
[36]
Xu Z. Study on the chemical constituents and biological activities of Prunella vulgaris. Zhongchengyao 1996; 18(11): 42-5.
[37]
Nátherová L, Leifertová I, Kunetková M. Evaluation of flavonoids in the domestic species of genus Fragaria L. Cesk Farm 1973; 22(10): 441-3.
[PMID: 4776919]
[38]
Tabba HD, Chang RS, Smith KM. Isolation, purification, and partial characterization of prunellin, an anti-HIV component from aqueous extracts of Prunella vulgaris. Antiviral Res 1989; 11(5-6): 263-73.
[http://dx.doi.org/10.1016/0166-3542(89)90036-3] [PMID: 2802570]
[39]
Jain M, Saxena V. Chemical examination of the fat from the leaves of Brunella vulgaris. J Inst Chem (India) 1984; 56(3): 133-4.
[40]
Mir RH, Shah AJ, Mohi-Ud-Din R, et al. Natural Anti-inflammatory Compounds as Drug Candidates in Alzheimer’s Disease. Curr Med Chem 2020.
[http://dx.doi.org/10.2174/0929867327666200730213215] [PMID: 32744957]
[41]
Mir RH, Sawhney G, Verma R, et al. Oreganum Vulgare: In-vitro assessment of cytotoxicity, Molecular docking studies, Antioxidant, and evaluation of anti-inflammatory activity in LPS stimulated RAW 264.7 cells. Shariqah, United Arab Emirates Medicinal Chemistry 2020.
[42]
Mir RH, Masoodi MH. Anti-inflammatory Plant Polyphenolics and Cellular Action Mechanisms. Curr Bioact Compd 2020; 16(6): 809-17.
[http://dx.doi.org/10.2174/1573407215666190419205317]
[43]
Mir RH, Masoodi MH. Phytochemical Screening and Liquid Chromatography-Mass Spectrometry Studies of Ethyl Acetate Extract of Origanum vulgare. Int J Pharm Investig 2020; 10(2): 132-5.
[http://dx.doi.org/10.5530/ijpi.2020.2.24]
[44]
Newman DJ, Cragg GM, Snader KM. The influence of natural products upon drug discovery. Nat Prod Rep 2000; 17(3): 215-34.
[http://dx.doi.org/10.1039/a902202c] [PMID: 10888010]
[45]
Dar MA, et al. Extensive Phytochemistry, Comprehensive Traditional Uses, and Critical Pharmacological Profile of the Great Mullein: Verbascum thapsus L. Nat Prod J 2019; 9(3): 158-71.
[http://dx.doi.org/10.2174/2210315508666180821153531]
[46]
Hassan R, Masoodi MH. Saussurea lappa: A Comprehensive Review on its Pharmacological Activity and Phytochemistry. Curr Tradit Med 2020; 6(1): 13-23.
[http://dx.doi.org/10.2174/2215083805666190626144909]
[47]
Rasool R, Ganai BA, Akbar S, Kamili AN, Masood A. Phytochemical screening of Prunella vulgaris l. - an important medicinal plant of Kashmir. Pak J Pharm Sci 2010; 23(4): 399-402.
[PMID: 20884453]
[48]
Psotová J, Kolár M, Sousek J, Svagera Z, Vicar J, Ulrichová J. Biological activities of Prunella vulgaris extract. Phytother Res 2003; 17(9): 1082-7.
[http://dx.doi.org/10.1002/ptr.1324] [PMID: 14595592]
[49]
Krygier K, Sosulski F, Hogge L. Free, esterified, and insoluble-bound phenolic acids. 1. Extraction and purification procedure. J Agric Food Chem 1982; 30(2): 330-4.
[http://dx.doi.org/10.1021/jf00110a028]
[50]
Kanokmedhakul S, Kanokmedhakul K, Lekphrom R. Bioactive constituents of the roots of Polyalthia cerasoides. J Nat Prod 2007; 70(9): 1536-8.
[http://dx.doi.org/10.1021/np070293a] [PMID: 17845001]
[51]
El-Jaber N, Estévez-Braun A, Ravelo AG, Muñoz-Muñoz O, Rodríguez-Afonso A, Murguia JR. Acetylenic acids from the aerial parts of Nanodea muscosa. J Nat Prod 2003; 66(5): 722-4.
[http://dx.doi.org/10.1021/np020513e] [PMID: 12762819]
[52]
Lu J, Qin R, Ye S, Yang M. Prunella vulgaris L. extract improves cellular immunity in MDR-TB challenged rats. J Med Coll PLA 2011; 26(4): 230-7.
[http://dx.doi.org/10.1016/S1000-1948(11)60040-3]
[53]
Rasool R, Ganai BA. Primella Vulgaris L. A Literature Review on its Therapeutic Potentials 2013.
[54]
Suh Y-A, Arnold RS, Lassegue B, et al. Cell transformation by the superoxide-generating oxidase Mox1. Nature 1999; 401(6748): 79-82.
[http://dx.doi.org/10.1038/43459] [PMID: 10485709]
[55]
Geiszt M, Kopp JB, Várnai P, Leto TL. Identification of renox, an NAD(P)H oxidase in kidney. Proc Natl Acad Sci USA 2000; 97(14): 8010-4.
[http://dx.doi.org/10.1073/pnas.130135897] [PMID: 10869423]
[56]
Asada K. Production and sacvenging of active oxygen in photosynthesis. Photoinhibition 1987; pp227-287.
[57]
Lamaison JL, Petitjean-Freytet C, Carnat A. [Medicinal Lamiaceae with antioxidant properties, a potential source of rosmarinic acid]. Pharm Acta Helv 1991; 66(7): 185-8.
[PMID: 1763093]
[58]
Liu F, Ng TB. Antioxidative and free radical scavenging activities of selected medicinal herbs. Life Sci 2000; 66(8): 725-35.
[http://dx.doi.org/10.1016/S0024-3205(99)00643-8] [PMID: 10680580]
[59]
Skottová N, Kazdová L, Oliyarnyk O, Vecera R, Sobolová L, Ulrichová J. Phenolics-rich extracts from Silybum marianum and Prunella vulgaris reduce a high-sucrose diet induced oxidative stress in hereditary hypertriglyceridemic rats. Pharmacol Res 2004; 50(2): 123-30.
[http://dx.doi.org/10.1016/j.phrs.2003.12.013] [PMID: 15177299]
[60]
Psotova J, Svobodova A, Kolarova H, Walterova D. Photoprotective properties of Prunella vulgaris and rosmarinic acid on human keratinocytes. J Photochem Photobiol B 2006; 84(3): 167-74.
[http://dx.doi.org/10.1016/j.jphotobiol.2006.02.012] [PMID: 16631374]
[61]
Jun MS, Kim HS, Kim YM, et al. Ethanol extract of Prunella vulgaris var. lilacina inhibits HMGB1 release by induction of heme oxygenase-1 in LPS-activated RAW 264.7 cells and CLP-induced septic mice. Phytother Res 2012; 26(4): 605-12.
[http://dx.doi.org/10.1002/ptr.3613] [PMID: 21971692]
[62]
Shin T-Y, Kim Y-K, Kim H-M. Inhibition of immediate-type allergic reactions by Prunella vulgaris in a murine model. Immunopharmacol Immunotoxicol 2001; 23(3): 423-35.
[http://dx.doi.org/10.1081/IPH-100107341] [PMID: 11694032]
[63]
Collins NH, Lessey EC, DuSell CD, et al. Characterization of antiestrogenic activity of the Chinese herb, prunella vulgaris, using in vitro and in vivo (Mouse Xenograft) models. Biol Reprod 2009; 80(2): 375-83.
[http://dx.doi.org/10.1095/biolreprod.107.065375] [PMID: 18923163]
[64]
Zdarilová A, Svobodová A, Simánek V, Ulrichová J. Prunella vulgaris extract and rosmarinic acid suppress lipopolysaccharide-induced alteration in human gingival fibroblasts. Toxicol In Vitro 2009; 23(3): 386-92.
[http://dx.doi.org/10.1016/j.tiv.2008.12.021] [PMID: 19159670]
[65]
Hwang SM, Kim JS, Lee YJ, et al. Anti-diabetic atherosclerosis effect of Prunella vulgaris in db/db mice with type 2 diabetes. Am J Chin Med 2012; 40(5): 937-51.
[http://dx.doi.org/10.1142/S0192415X12500693] [PMID: 22928826]
[66]
Horikawa K, Mohri T, Tanaka Y, Tokiwa H. Moderate inhibition of mutagenicity and carcinogenicity of benzo[a]pyrene, 1,6-dinitropyrene and 3,9-dinitrofluoranthene by Chinese medicinal herbs. Mutagenesis 1994; 9(6): 523-6.
[http://dx.doi.org/10.1093/mutage/9.6.523] [PMID: 7854143]
[67]
Xia N, Bollinger L, Steinkamp-Fenske K, Förstermann U, Li H. Prunella vulgaris L. Upregulates eNOS expression in human endothelial cells. Am J Chin Med 2010; 38(3): 599-611.
[http://dx.doi.org/10.1142/S0192415X10008081] [PMID: 20503475]
[68]
Zhang KJ, Zhang MZ, Wang QD, Liu WL. [The experimental research about the effect of Prunella vulgaris L. on Raji cells growth and expression of apoptosis related protein]. Zhong Yao Cai 2006; 29(11): 1207-10.
[PMID: 17228664]
[69]
Lin Y, Yang C, Tang J, et al. Characterization and anti-uterine tumor effect of extract from Prunella vulgaris L. BMC complementary medicine and therapies 2020; 20(1): 1-11..
[70]
Huang M, et al. Anti-tumor Properties of Prunella vulgaris. Curr Pharmacol Rep 2015; 1(6): 401-19.
[http://dx.doi.org/10.1007/s40495-015-0038-6]
[71]
Feng L, Jia XB, Shi F, Chen Y. Identification of two polysaccharides from Prunella vulgaris L. and evaluation on their anti-lung adenocarcinoma activity. Molecules 2010; 15(8): 5093-103.
[http://dx.doi.org/10.3390/molecules15085093] [PMID: 20714287]
[72]
Fu XR, Sun ZC, Zhang MZ. [Experimental study of extract from Prunella vulgaris inducing B, T lymphoma cell apoptosis]. Zhong Yao Cai 2012; 35(3): 433-8.
[PMID: 22876685]
[73]
Xu W, Tan L, Wang HF, et al. Meta-analysis of modifiable risk factors for Alzheimer’s disease. J Neurol Neurosurg Psychiatry 2015; 86(12): 1299-306.
[http://dx.doi.org/10.1136/jnnp-2015-310548] [PMID: 26294005]
[74]
Juan ME, Planas JM, Ruiz-Gutierrez V, Daniel H, Wenzel U. Antiproliferative and apoptosis-inducing effects of maslinic and oleanolic acids, two pentacyclic triterpenes from olives, on HT-29 colon cancer cells. Br J Nutr 2008; 100(1): 36-43.
[http://dx.doi.org/10.1017/S0007114508882979] [PMID: 18298868]
[75]
Song J, Zhao M, Zhang Z, et al. Effects of a Long-Term Administration of Aqueous Extract of Prunella vulgaris L. on Survival. Spontaneous Thyroid Carcinoma and Neoplastic C-cell Hyperplasia in Rats 2020.
[76]
Zhang X, Shen T, Zhou X, et al. Network pharmacology based virtual screening of active constituents of Prunella vulgaris L. and the molecular mechanism against breast cancer. Sci Rep 2020; 10(1): 15730.
[http://dx.doi.org/10.1038/s41598-020-72797-8] [PMID: 32978480]
[77]
Chen C, Wu G, Zhang M. The effects and mechanism of action of Prunella vulgaris l extract on Jurkat human T lymphoma cell proliferation. Chinese-German J Clin Oncol 2009; 8(7): 426-9.
[http://dx.doi.org/10.1007/s10330-009-0067-x]
[78]
Lin W, Zheng L, Zhuang Q, et al. Spica Prunellae extract inhibits the proliferation of human colon carcinoma cells via the regulation of the cell cycle. Oncol Lett 2013; 6(4): 1123-7.
[http://dx.doi.org/10.3892/ol.2013.1512] [PMID: 24137475]
[79]
Mofei H, Yian W, Ling X, et al. The effect of Prunella vulgaris L. on Eca109 cells. J Basic Clin Oncol 2006; 19(3): 199-200.
[80]
Hwang Y-J, Lee EJ, Kim HR, Hwang KA. In vitro antioxidant and anticancer effects of solvent fractions from Prunella vulgaris var. lilacina. BMC Complement Altern Med 2013; 13(1): 310.
[http://dx.doi.org/10.1186/1472-6882-13-310] [PMID: 24206840]
[81]
Chiej R. The Macdonald encyclopedia of medicinal plants 1984.
[82]
Lawson SK, Sharp LG, Satyal P, et al. Volatile components of the aerial parts of Prunella vulgaris L.(Lamiaceae). Am J Essential Oils Nat Products 2020; 8(1): 17-9.
[83]
Zhang M, Wang X. Effects of extract from Prunella vulgaris combined with chemotherapeutic agents on proliferation of lymphoma cells. Tumor 2009; 29(10): 961-4.
[84]
Meng WW, Huang XM, Lu DC, et al. Prunella vulgaris and crenastra appendiculata anti-proliferate thyroid cancer cell in vitro. China J Mod Med 2012; 22(28): 46-50.
[85]
Liu G-Y, Luo Q, Xiong B, et al. Tissue array for Tp53, C-myc, CCND1 gene over-expression in different tumors. World J Gastroenterol 2008; 14(47): 7199-207.
[http://dx.doi.org/10.3748/wjg.14.7199] [PMID: 19084934]
[86]
Grosan A, Ștefanescu R, Gurzu S, et al. Study of the potential antiulcerous action of hydroalcoholic extracts from prunella vulgaris l. of romanian origin. farmacia 2020; 68(5): 870-881..
[87]
Lee IK, Kim DH, Lee SY, et al. Triterpenoic acids of Prunella vulgaris var. lilacina and their cytotoxic activities in vitro. Arch Pharm Res 2008; 31(12): 1578-83.
[http://dx.doi.org/10.1007/s12272-001-2154-6] [PMID: 19099227]
[88]
Kim J-H, Kim YH, Song GY, et al. Ursolic acid and its natural derivative corosolic acid suppress the proliferation of APC-mutated colon cancer cells through promotion of β-catenin degradation. Food Chem Toxicol 2014; 67: 87-95.
[http://dx.doi.org/10.1016/j.fct.2014.02.019] [PMID: 24566423]
[89]
Simon A, Najid A, Chulia AJ, Delage C, Rigaud M. Inhibition of lipoxygenase activity and HL60 leukemic cell proliferation by ursolic acid isolated from heather flowers (Calluna vulgaris). Biochim Biophys Acta 1992; 1125(1): 68-72.
[http://dx.doi.org/10.1016/0005-2760(92)90157-Q] [PMID: 1567909]
[90]
Es-saady D, Simon A, Ollier M, Maurizis JC, Chulia AJ, Delage C. Inhibitory effect of ursolic acid on B16 proliferation through cell cycle arrest. Cancer Lett 1996; 106(2): 193-7.
[http://dx.doi.org/10.1016/0304-3835(96)04312-1] [PMID: 8844972]
[91]
Es-Saady D, Simon A, Jayat-Vignoles C, Chulia AJ, Delage C. MCF-7 cell cycle arrested at G1 through ursolic acid, and increased reduction of tetrazolium salts. Anticancer Res 1996; 16(1): 481-6.
[PMID: 8615658]
[92]
Ahmad G, Masoodi MH, Tabassum N, et al. Phytochemical Analysis and Anti-inflammatory Activity of Various Extracts Obtained from Floral Spikes of Prunella Vulgaris L. Jordan J Pharm Sci 2020; 13(1)
[93]
Liu M, Hu DJ, Xia X, et al. Studies on the anti-tumor substances of an endophytic fungus CPCC 480171 isolated from Prunella vulgaris. Pharm Biotechnol 2008; 15(4): 262-5.
[94]
Rajendra Prasad N, Karthikeyan A, Karthikeyan S, Reddy BV. Inhibitory effect of caffeic acid on cancer cell proliferation by oxidative mechanism in human HT-1080 fibrosarcoma cell line. Mol Cell Biochem 2011; 349(1-2): 11-9.
[http://dx.doi.org/10.1007/s11010-010-0655-7] [PMID: 21116690]
[95]
Wang K, Dong HF, Zhang XY, et al. The effect of Prunella vulgaris L on SGC-7901 Cells. Shanghai J Med Lab Sci 2000; 15: 305-7.
[96]
Yin DT, Lei M, Xu J, et al. The Chinese herb Prunella vulgaris promotes apoptosis in human well-differentiated thyroid carcinoma cells via the B-cell lymphoma-2/Bcl-2-associated X protein/caspase-3 signaling pathway. Oncol Lett 2017; 14(2): 1309-14.
[http://dx.doi.org/10.3892/ol.2017.6317] [PMID: 28808482]
[97]
FU , X.-r. , et al. Effect and mechanism of Prunella vulgaris L extract on proliferation of human Burkitt lymphoma cell line Raji. Shandong Yiyao 2008; 24. [J].
[98]
Lukiw WJ, Cui JG, Li YY, Culicchia F. Up-regulation of micro-RNA-221 (miRNA-221; chr Xp11.3) and caspase-3 accompanies down-regulation of the survivin-1 homolog BIRC1 (NAIP) in glioblastoma multiforme (GBM). J Neurooncol 2009; 91(1): 27-32.
[http://dx.doi.org/10.1007/s11060-008-9688-0] [PMID: 18759060]
[99]
Murphy BT, MacKinnon SL, Yan X, Hammond GB, Vaisberg AJ, Neto CC. Identification of triterpene hydroxycinnamates with in vitro antitumor activity from whole cranberry fruit (Vaccinium macrocarpon). J Agric Food Chem 2003; 51(12): 3541-5.
[http://dx.doi.org/10.1021/jf034114g] [PMID: 12769521]
[100]
Feng L, Jia X, Zhu M, Chen Y, Shi F. Chemoprevention by Prunella vulgaris L. extract of non-small cell lung cancer via promoting apoptosis and regulating the cell cycle. Asian Pac J Cancer Prev 2010; 11(5): 1355-8.
[PMID: 21198292]
[101]
Lin W, Zheng L, Zhuang Q, et al. Spica prunellae promotes cancer cell apoptosis, inhibits cell proliferation and tumor angiogenesis in a mouse model of colorectal cancer via suppression of stat3 pathway. BMC Complement Altern Med 2013; 13(1): 144.
[http://dx.doi.org/10.1186/1472-6882-13-144] [PMID: 23800091]
[102]
Mao X, Wang G, Zhang W, Li S. A study on inhibitory effect of Spica prunellae extract on T lymphoma cell EL-4 tumour. Afr J Tradit Complement Altern Med 2013; 10(5): 318-24.
[PMID: 24311843]
[103]
Furtado RA, Oliveira BR, Silva LR, et al. Chemopreventive effects of rosmarinic acid on rat colon carcinogenesis. Eur J Cancer Prev 2015; 24(2): 106-12.
[http://dx.doi.org/10.1097/CEJ.0000000000000055] [PMID: 24977626]
[104]
Casella ML, Parody JP, Ceballos MP, et al. Quercetin prevents liver carcinogenesis by inducing cell cycle arrest, decreasing cell proliferation and enhancing apoptosis. Mol Nutr Food Res 2014; 58(2): 289-300.
[http://dx.doi.org/10.1002/mnfr.201300362] [PMID: 24124108]
[105]
Xu Y, Xu G, Liu L, Xu D, Liu J. Anti-invasion effect of rosmarinic acid via the extracellular signal-regulated kinase and oxidation-reduction pathway in Ls174-T cells. J Cell Biochem 2010; 111(2): 370-9.
[http://dx.doi.org/10.1002/jcb.22708] [PMID: 20506543]
[106]
Sun H-X, Qin F, Pan Y-J. In vitro and in vivo immunosuppressive activity of Spica Prunellae ethanol extract on the immune responses in mice. J Ethnopharmacol 2005; 101(1-3): 31-6.
[http://dx.doi.org/10.1016/j.jep.2005.03.023] [PMID: 15919165]
[107]
Harput US, Saracoglu I, Ogihara Y. Effects of two Prunella species on lymphocyte proliferation and nitric oxide production. Phytother Res 2006; 20(2): 157-9.
[http://dx.doi.org/10.1002/ptr.1805] [PMID: 16444671]
[108]
Han EH, Choi JH, Hwang YP, et al. Immunostimulatory activity of aqueous extract isolated from Prunella vulgaris. Food Chem Toxicol 2009; 47(1): 62-9.
[http://dx.doi.org/10.1016/j.fct.2008.10.010] [PMID: 18983886]
[109]
Harikrishnan R, Kim JS, Kim MC, et al. Prunella vulgaris enhances the non-specific immune response and disease resistance of Paralichthys olivaceus against Uronema marinum. Aquaculture 2011; 318(1): 61-6.
[http://dx.doi.org/10.1016/j.aquaculture.2011.05.020]

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