A Review of the Effects of Gold, Silver, Selenium, and Zinc Nanoparticles on Diabetes Mellitus in Murine Models

Title:A Review of the Effects of Gold, Silver, Selenium, and Zinc Nanoparticles on Diabetes Mellitus in Murine Models

Volume: 21 Issue: 14

Author(s): Fernando Martínez-Esquivias , Juan Manuel Guzmán-Flores*, Alejandro Pérez-Larios, José Luis Rico and Julieta Saraí Becerra-Ruiz

Affiliation:

• Instituto de Investigacion en Biociencias, Centro Universitario de Los Altos, Universidad de Guadalajara, Tepatitlan de Morelos, Jalisco,Mexico

Keywords: metal nanoparticles, diabetes, gold, silver, selenium, zinc.

Abstract: Diabetes mellitus is a disease that presents great challenges for healthcare systems worldwide, and the identification of alternative therapies for the treatment of this disease is of vital importance. Metallic nanoparticles (gold, silver, and selenium) and metallic oxide (ZnO) have been studied in different areas such as medicine, biotechnology, the environment, and the food industry with promising results. In medicine, current research has revealed these nanoparticles' anti-diabetic properties thanks to the implementation of animal models. This review will address the existing antecedents and the effects of gold, silver, selenium, and zinc oxide nanoparticles in diabetes administered alone, functionalized with other molecules, or combined with drugs that have shown promising therapeutic effects. The anti-diabetic effects of these nanoparticles are related to the regulation of glucose, insulin, and lipid profiles. In addition, oxidative stress markers, liver and kidney markers, the reduction of inflammation, apoptosis of the pancreas, and the restoration of normal liver and kidney histology are also reported in the literature after using these nanoparticles. However, the therapeutic effects that these nanoparticles provide are limited due to the lack of specific protocols dictated by international organizations to evaluate the risks of using these nanoparticles.

Cite this article as:

Martínez-Esquivias Fernando , Guzmán-Flores Manuel Juan *, Pérez-Larios Alejandro , Rico Luis José and Becerra-Ruiz Saraí Julieta , A Review of the Effects of Gold, Silver, Selenium, and Zinc Nanoparticles on Diabetes Mellitus in Murine Models, Mini-Reviews in Medicinal Chemistry 2021; 21 (14) . https://dx.doi.org/10.2174/1389557521666210203154024