Abstract
Introduction: COVID-19 pandemic represents a major health issue caused by SARS CoV2, a human coronavirus. Since the outbreak of this pandemic, the literature on SARS CoV-2 has grown differentially, with increased awareness of extra-respiratory symptoms, including neurological symptoms.
Methods: Review based on studies published from December 2019 to June 2020.
Results and Discussion: This review discusses the neurological aspect of SARS CoV2, including the suggested mechanism involved. Neurological disorders are cited in addition to emerging experimental models with viral involvement.
Conclusion: There is a need for further investigation to clarify how it can lead to the onset of acute and chronic neurological disorders, mentioning the importance of experimental studies in neuropsychopharmacology.
Keywords: COVID-19, SARS CoV2, nervous system, neuropsychopharmacology, neurological disorders, central nervous system.
[http://dx.doi.org/10.4149/av_2017_401] [PMID: 29186956]
[http://dx.doi.org/10.1016/j.bbi.2020.03.031] [PMID: 32240762]
[http://dx.doi.org/10.1016/S2213-2600(20)30076-X] [PMID: 32085846]
[http://dx.doi.org/10.1093/infdis/jiv499] [PMID: 26486634]
[http://dx.doi.org/10.1128/JVI.00737-08] [PMID: 18495771]
[http://dx.doi.org/10.3389/fncel.2018.00386] [PMID: 30416428]
[http://dx.doi.org/10.1371/journal.ppat.0030005] [PMID: 17222058]
[http://dx.doi.org/10.1086/515386] [PMID: 9728532]
[http://dx.doi.org/10.1084/jem.20050828] [PMID: 16043521]
[http://dx.doi.org/10.1001/jamaneurol.2020.1127] [PMID: 32275288]
[http://dx.doi.org/10.1148/radiol.2020201187]
[http://dx.doi.org/10.7759/cureus.7352] [PMID: 32328364]
[http://dx.doi.org/10.1016/j.neurol.2020.04.007] [PMID: 32359804]
[http://dx.doi.org/10.1186/s12883-020-01796-z] [PMID: 32460711]
[http://dx.doi.org/10.1128/JCM.00730-16] [PMID: 27335149]
[http://dx.doi.org/10.1016/j.coviro.2014.12.009] [PMID: 25681709]
[http://dx.doi.org/10.1016/S0140-6736(20)30628-0] [PMID: 32192578]
[http://dx.doi.org/10.3201/eid1708.101528] [PMID: 21801621]
[http://dx.doi.org/10.1056/NEJMoa2002032] [PMID: 32109013]
[http://dx.doi.org/10.1021/acschemneuro.0c00122] [PMID: 32167747]
[http://dx.doi.org/10.1016/j.wneu.2020.05.193] [PMID: 32474093] [PMCID: PMC7255736]
[http://dx.doi.org/10.3892/ijmm.2020.4608] [PMID: 32468014]
[http://dx.doi.org/10.1016/j.wneu.2020.05.193] [PMID: 32474093] [PMCID: PMC7255736]
[http://dx.doi.org/10.1007/s00415-020-09896-z] [PMID: 32436101]
[PMID: 27957611]