Generic placeholder image

Endocrine, Metabolic & Immune Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Research Article

Hidden Hunger of Vitamin E among Healthy College Students: A Cross- Sectional Study

Author(s): Zhongqi Wan, Li Wang, Yinyang Xu, Yuanyuan Wang, Tianyou Zhang, Xinlan Mao, Qiao Li, Yangzhi Zhu, Ming Zhou* and Zhong Li*

Volume 21, Issue 6, 2021

Published on: 01 January, 2021

Page: [1025 - 1030] Pages: 6

DOI: 10.2174/1871530321666210101165648

Abstract

Background: College students may have a risk of fat-soluble vitamin deficiencies due to unhealthy dietary habits, especially for vitamin A and E. They are important members of the human antioxidant network; deficiencies of these vitamins may increase the risk of many critical diseases.

Objective: The current study was undertaken to determine the status of vitamin A and E in college students.

Methods: Healthy college students were recruited, and fasting blood samples of them were collected and used for determining serum levels of retinol and α-tocopherol by the HPLC method.

Results: We found that there was no vitamin A deficiency in college students. However, vitamin E deficiency existed in 34.5% of college students, especially in males. All the students had no vitamin E adequacy. In addition, our findings showed that BMI was inversely associated with serum α-- tocopherol, but not serum retinol.

Conclusion: These results suggest that vitamin E deficiency in college students should be given more attention, and it is necessary to consider using vitamin E supplements.

Keywords: Hidden hunger, fat-soluble vitamins, vitamin A, vitamin E, BMI, college students.

Graphical Abstract

[1]
de Oliveira, L.F.; de Azevedo, L.G.; da Mota Santana, J.; de Sales, L.P.C.; Pereira-Santos, M. Obesity and overweight decreases the effect of vitamin D supplementation in adults: systematic review and meta-analysis of randomized controlled trials. Rev. Endocr. Metab. Disord., 2020, 21(1), 67-76.
[http://dx.doi.org/10.1007/s11154-019-09527-7] [PMID: 31832878]
[2]
Yang, C.S.; Luo, P.; Zeng, Z.; Wang, H.; Malafa, M.; Suh, N. Vitamin E and cancer prevention: Studies with different forms of tocopherols and tocotrienols. Mol. Carcinog., 2020, 59(4), 365-389.
[http://dx.doi.org/10.1002/mc.23160] [PMID: 32017273]
[3]
Martens, P.J.; Gysemans, C.; Verstuyf, A.; Mathieu, A.C. Vitamin D’s Effect on Immune Function. Nutrients, 2020, 12(5), 1248.
[http://dx.doi.org/10.3390/nu12051248] [PMID: 32353972]
[4]
Brown, C.C.; Noelle, R.J. Seeing through the dark: New insights into the immune regulatory functions of vitamin A. Eur. J. Immunol., 2015, 45(5), 1287-1295.
[http://dx.doi.org/10.1002/eji.201344398] [PMID: 25808452]
[5]
Albahrani, A.A.; Greaves, R.F. Fat-Soluble Vitamins: Clinical Indications and Current Challenges for Chromatographic Measurement. Clin. Biochem. Rev., 2016, 37(1), 27-47.
[PMID: 27057076]
[6]
Al-Daghri, N.M.; Abd-Alrahman, S.H.; Panigrahy, A.; Al-Saleh, Y.; Aljohani, N.; Al-Attas, O.S.; Khattak, M.N.K.; Alokail, M. Efficacy of Vitamin D interventional strategies in saudi children and adults. J. Steroid Biochem. Mol. Biol., 2018, 180, 29-34.
[http://dx.doi.org/10.1016/j.jsbmb.2017.12.004] [PMID: 29247784]
[7]
Nimri, L.F. Vitamin D status of female UAE college students and associated risk factors. J. Public Health (Oxf.), 2018, 40(3), e284-e290.
[http://dx.doi.org/10.1093/pubmed/fdy009] [PMID: 29385507]
[8]
BinSaeed, A.A.; Torchyan, A.A.; AlOmair, B.N.; AlQadhib, N.S.; AlSuwayeh, F.M.; Monshi, F.M.; AlRumaih, F.I.; AlQahtani, S.A.; AlYousefi, N.; Al-Drees, A. Determinants of vitamin D deficiency among undergraduate medical students in Saudi Arabia. Eur. J. Clin. Nutr., 2015, 69(10), 1151-1155.
[http://dx.doi.org/10.1038/ejcn.2014.286] [PMID: 25690868]
[9]
Zhou, M.; Zhuang, W.; Yuan, Y.; Li, Z.; Cai, Y. Investigation on vitamin D knowledge, attitude and practice of university students in Nanjing, China. Public Health Nutr., 2016, 19(1), 78-82.
[http://dx.doi.org/10.1017/S1368980015000373] [PMID: 25702904]
[10]
Martinez-Ferran, M.; Sanchis-Gomar, F.; Lavie, C.J.; Lippi, G.; Pareja-Galeano, H. Do Antioxidant Vitamins Prevent Exercise-Induced Muscle Damage? A Systematic Review. Antioxidants, 2020, 9(5), 372.
[http://dx.doi.org/10.3390/antiox9050372] [PMID: 32365669]
[11]
Koekkoek, W.A.C.K.; van Zanten, A.R.H. Antioxidant Vitamins and Trace Elements in Critical Illness. Nutr. Clin. Pract., 2016, 31(4), 457-474.
[http://dx.doi.org/10.1177/0884533616653832] [PMID: 27312081]
[12]
Ssentongo, P.; Ba, D.M.; Ssentongo, A.E.; Fronterre, C.; Whalen, A.; Yang, Y.; Ericson, J.E.; Chinchilli, V.M. Association of vitamin A deficiency with early childhood stunting in Uganda: A population-based cross-sectional study. PLoS One, 2020, 15(5), e0233615.
[http://dx.doi.org/10.1371/journal.pone.0233615] [PMID: 32470055]
[13]
Bastos Maia, S.; Rolland Souza, A.S.; Costa Caminha, M.F.; Lins da Silva, S.; Callou Cruz, R.S.B.L.; Carvalho Dos Santos, C.; Batista Filho, M. Vitamin A and Pregnancy: A Narrative Review. Nutrients, 2019, 11(3), 681.
[http://dx.doi.org/10.3390/nu11030681] [PMID: 30909386]
[14]
Dror, D.K.; Allen, L.H.D.K. Vitamin E deficiency in developing countries. Food Nutr. Bull., 2011, 32(2), 124-143.
[http://dx.doi.org/10.1177/156482651103200206] [PMID: 22164974]
[15]
Traber, M.G.; Vitamin, E. Vitamin E inadequacy in humans: causes and consequences. Adv. Nutr., 2014, 5(5), 503-514.
[http://dx.doi.org/10.3945/an.114.006254] [PMID: 25469382]
[16]
Burri, B.J.; Dopler-Nelson, M.; Neidllinger, T.R. Measurements of the major isoforms of vitamins A and E and carotenoids in the blood of people with spinal-cord injuries. J. Chromatogr. A, 2003, 987(1-2), 359-366.
[http://dx.doi.org/10.1016/S0021-9673(02)01908-8] [PMID: 12613829]
[17]
Sommer, A.; Davidson, F.R. Assessment and control of vitamin A deficiency: the Annecy Accords. J. Nutr., 2002, 132(9)(Suppl.), 2845S-2850S.
[http://dx.doi.org/10.1093/jn/132.9.2845S] [PMID: 12221259]
[18]
McBurney, M.I.; Yu, E.A.; Ciappio, E.D.; Bird, J.K.; Eggersdorfer, M.; Mehta, S. Suboptimal Serum α-Tocopherol Concentrations Observed among Younger Adults and Those Depending Exclusively upon Food Sources, NHANES 2003-20061-3. PLoS One, 2015, 10(8), e0135510.
[http://dx.doi.org/10.1371/journal.pone.0135510] [PMID: 26287975]
[19]
Wright, M.E.; Lawson, K.A.; Weinstein, S.J.; Pietinen, P.; Taylor, P.R.; Virtamo, J.; Albanes, D. Higher baseline serum concentrations of vitamin E are associated with lower total and cause-specific mortality in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Am. J. Clin. Nutr., 2006, 84(5), 1200-1207.
[http://dx.doi.org/10.1093/ajcn/84.5.1200] [PMID: 17093175]
[20]
Traber, M.G.; Stevens, J.F. Vitamins C and E: beneficial effects from a mechanistic perspective. Free Radic. Biol. Med., 2011, 51(5), 1000-1013.
[http://dx.doi.org/10.1016/j.freeradbiomed.2011.05.017] [PMID: 21664268]
[21]
Harding, K.L.; Aguayo, V.M.; Webb, P. Hidden hunger in South Asia: a review of recent trends and persistent challenges. Public Health Nutr., 2018, 21(4), 785-795.
[http://dx.doi.org/10.1017/S1368980017003202] [PMID: 29256361]
[22]
Al-Qahtani, M.H. Dietary Habits of Saudi Medical Students at University of Dammam. Int. J. Health Sci. (Qassim), 2016, 10(3), 353-362.
[http://dx.doi.org/10.12816/0048729] [PMID: 27610058]
[23]
Bawadi, H.; Khataybeh, T.; Obeidat, B.; Kerkadi, A.; Tayyem, R.; Banks, A.D.; Subih, H. Sugar-Sweetened Beverages Contribute Significantly to College Students’ Daily Caloric Intake in Jordan: Soft Drinks Are Not the Major Contributor. Nutrients, 2019, 11(5), 1058.
[http://dx.doi.org/10.3390/nu11051058] [PMID: 31083526]
[24]
Hiraoka, M. Nutritional status of vitamin A, E, C, B1, B2, B6, nicotinic acid, B12, folate, and beta-carotene in young women. J. Nutr. Sci. Vitaminol. (Tokyo), 2001, 47(1), 20-27.
[http://dx.doi.org/10.3177/jnsv.47.20] [PMID: 11349886]
[25]
Du, S.S.; Jiang, Y.S.; Chen, Y.; Li, Z.; Zhang, Y.F.; Sun, C.H.; Feng, R.N. Development and Applicability of an Internet-Based Diet and Lifestyle Questionnaire for College Students in China: A Cross-Sectional Study. Medicine (Baltimore), 2015, 94(49), e2130.
[http://dx.doi.org/10.1097/MD.0000000000002130] [PMID: 26656341]
[26]
Ene-Obong, H.N.; Odoh, I.F.; Ikwuagwu, O.E. Plasma vitamin A and C status of in-school adolescents and associated factors in Enugu State, Nigeria. J. Health Popul. Nutr., 2003, 21(1), 18-25.
[PMID: 12751670]
[27]
de Pee, S.; Yuniar, Y.; West, C.E.; Muhilal, Evaluation of biochemical indicators of vitamin A status in breast-feeding and non-breast-feeding Indonesian women. Am. J. Clin. Nutr., 1997, 66(1), 160-167.
[http://dx.doi.org/10.1093/ajcn/66.1.160] [PMID: 9209185]
[28]
Woestenenk, J.W.; Broos, N.; Stellato, R.K.; Arets, H.G.M.; van der Ent, C.K.; Houwen, R.H.J. Vitamin A intake and serum retinol levels in children and adolescents with cystic fibrosis. Clin. Nutr., 2016, 35(3), 654-659.
[http://dx.doi.org/10.1016/j.clnu.2015.04.010] [PMID: 25975494]
[29]
Jacques, P.F.; Sulsky, S.I.; Sadowski, J.A.; Phillips, J.C.; Rush, D.; Willett, W.C. Comparison of micronutrient intake measured by a dietary questionnaire and biochemical indicators of micronutrient status. Am. J. Clin. Nutr., 1993, 57(2), 182-189.
[http://dx.doi.org/10.1093/ajcn/57.2.182] [PMID: 8424386]
[30]
Alghadir, A.H.; Gabr, S.A.; Iqbal, Z.A.; Al-Eisa, E. Association of physical activity, vitamin E levels, and total antioxidant capacity with academic performance and executive functions of adolescents. BMC Pediatr., 2019, 19(1), 156.
[http://dx.doi.org/10.1186/s12887-019-1528-1] [PMID: 31101100]
[31]
Morrissey, P.A.; Sheehy, P.J.A. Optimal nutrition: vitamin E. Proc. Nutr. Soc., 1999, 58(2), 459-468.
[http://dx.doi.org/10.1017/S0029665199000609] [PMID: 10466191]
[32]
Breidenassel, C.; Valtueña, J.; González-Gross, M.; Benser, J.; Spinneker, A.; Moreno, L.A.; de Henauw, S.; Widhalm, K.; Molnar, D.; Maiani, G.; Stehle, P. Antioxidant vitamin status (A, E, C, and beta-carotene) in European adolescents - the HELENA Study. Int. J. Vitam. Nutr. Res., 2011, 81(4), 245-255.
[http://dx.doi.org/10.1024/0300-9831/a000070] [PMID: 22237774]
[33]
Salas-Huetos, A.; Bulló, M.; Salas-Salvadó, J. Dietary patterns, foods and nutrients in male fertility parameters and fecundability: a systematic review of observational studies. Hum. Reprod. Update, 2017, 23(4), 371-389.
[http://dx.doi.org/10.1093/humupd/dmx006] [PMID: 28333357]
[34]
McGavin, J.K.; Mann, J.I.; Skeaff, C.M.; Chisholm, A. Comparison of a vitamin E-rich diet and supplemental vitamin E on measures of vitamin E status and lipoprotein profile. Eur. J. Clin. Nutr., 2001, 55(7), 555-561.
[http://dx.doi.org/10.1038/sj.ejcn.1601182] [PMID: 11464229]
[35]
Thomas-Valdés, S.; Tostes, M.D.G.V.; Anunciação, P.C.; da Silva, B.P.; Sant’Ana, H.M.P. Association between vitamin deficiency and metabolic disorders related to obesity. Crit. Rev. Food Sci. Nutr., 2017, 57(15), 3332-3343.
[http://dx.doi.org/10.1080/10408398.2015.1117413] [PMID: 26745150]
[36]
Luna, R.C.P.; do Nascimento, C.C.; Asciutti, L.S.R.; Franceschini, Sdo.C.; Filizola, R.G.; Diniz, Ada.S.; de Moraes, R.M.; Rivera, M.A.; Gonçalves, Mda.C.; Costa, M.J. Relation between glucose levels, high-sensitivity C-reactive protein (hs-CRP), body mass index (BMI) and serum and dietary retinol in elderly in population-based study. Arch. Gerontol. Geriatr., 2012, 54(3), 462-468.
[http://dx.doi.org/10.1016/j.archger.2011.06.005] [PMID: 21764149]
[37]
Gunanti, I.R.; Marks, G.C.; Al-Mamun, A.; Long, K.Z. Low serum concentrations of carotenoids and vitamin E are associated with high adiposity in Mexican-American children. J. Nutr., 2014, 144(4), 489-495.
[http://dx.doi.org/10.3945/jn.113.183137] [PMID: 24500938]
[38]
Palmieri, V.O.; Grattagliano, I.; Portincasa, P.; Palasciano, G. Systemic oxidative alterations are associated with visceral adiposity and liver steatosis in patients with metabolic syndrome. J. Nutr., 2006, 136(12), 3022-3026.
[http://dx.doi.org/10.1093/jn/136.12.3022] [PMID: 17116714]
[39]
Wong, S.K.; Chin, K.Y.; Suhaimi, F.H.; Ahmad, F.; Ima-Nirwana, S.; Vitamin, E.; Vitamin, E. Vitamin E As a Potential Interventional Treatment for Metabolic Syndrome: Evidence from Animal and Human Studies. Front. Pharmacol., 2017, 8, 444.
[http://dx.doi.org/10.3389/fphar.2017.00444] [PMID: 28725195]
[40]
Galli, F.; Azzi, A.; Birringer, M.; Cook-Mills, J.M.; Eggersdorfer, M.; Frank, J.; Cruciani, G.; Lorkowski, S.; Özer, N.K.; Vitamin, E.; Vitamin, E. Vitamin E: Emerging aspects and new directions. Free Radic. Biol. Med., 2017, 102, 16-36.
[http://dx.doi.org/10.1016/j.freeradbiomed.2016.09.017] [PMID: 27816611]
[41]
Sozen, E.; Demirel, T.; Ozer, N.K.; Vitamin, E.; Vitamin, E. Vitamin E: Regulatory role in the cardiovascular system. IUBMB Life, 2019, 71(4), 507-515.
[http://dx.doi.org/10.1002/iub.2020] [PMID: 30779288]

© 2024 Bentham Science Publishers | Privacy Policy