Association of Admission Leukocyte Count with Clinical Outcomes in Acute Ischemic Stroke Patients Undergoing Intravenous Thrombolysis with Recombinant Tissue Plasminogen Activator

Title:Association of Admission Leukocyte Count with Clinical Outcomes in Acute Ischemic Stroke Patients Undergoing Intravenous Thrombolysis with Recombinant Tissue Plasminogen Activator

Volume: 17 Issue: 5

Author(s): Jie Chen, Fu-Liang Zhang, Shan Lv, Hang Jin, Yun Luo, Yang Qu, Zhen-Ni Guo*Yi Yang*

Affiliation:

• China National Comprehensive Stroke Center, Department of Neurology, the First Hospital of Jilin University, Xinmin Street No. 1, Chang Chun,China

• China National Comprehensive Stroke Center, Department of Neurology, the First Hospital of Jilin University, Xinmin Street No. 1, Chang Chun,China

Keywords: Acute ischemic stroke, leucocyte count, rt-PA, mortality, functional outcomes, thrombolysis.

Abstract:

Objective: An increased leukocyte count is positively associated with poor outcomes and all-cause mortality in coronary heart disease, cancer, and ischemic stroke. The role of leukocyte count in acute ischemic stroke (AIS) remains important. We aimed to investigate the association between admission leukocyte count before thrombolysis with recombinant tissue plasminogen activator (rt-PA) and 3-month outcomes in AIS patients.

Methods: This retrospective study included consecutive AIS patients who received intravenous (IV) rt-PA within 4.5 h of symptom onset between January 2016 to December 2018. We assessed outcomes, including short-term hemorrhagic transformation (HT), 3-month mortality, and functional independence (modified Rankin Scale [mRS] score of 0–2 or 0–1).

Results: Among 579 patients who received IV rt-PA, 77 (13.3%) exhibited HT at 24 h, 43 (7.4%) died within 3 months, and 211 (36.4%) exhibited functional independence (mRS score: 0–2). Multivariable logistic regression revealed admission leukocyte count as an independent predictor of good and excellent outcomes at 3 months. Each 1-point increase in admission leukocyte count increased the odds of poor outcomes at 3 months by 7.6% (mRS score: 3–6, odds ratio [OR]: 1.076, 95% confidence interval [CI]: 1.003–1.154, p=0.041) and 7.8% (mRS score: 2–6, OR: 1.078, 95% CI: 1.006–1.154, p=0.033). Multivariable regression analysis revealed no association between HT and 3-month mortality. Admission neutrophil and lymphocyte count were not associated with 3-- month functional outcomes or 3-month mortality.

Conclusion: A lower admission leukocyte count independently predicts good and excellent outcomes at 3 months in AIS patients undergoing rt-PA treatment.

Cite this article as:

Chen Jie , Zhang Fu-Liang , Lv Shan , Jin Hang , Luo Yun , Qu Yang , Guo Zhen-Ni *, Yang Yi *, Association of Admission Leukocyte Count with Clinical Outcomes in Acute Ischemic Stroke Patients Undergoing Intravenous Thrombolysis with Recombinant Tissue Plasminogen Activator, Current Neurovascular Research 2020; 17 (5) . https://dx.doi.org/10.2174/1567202617999201125201616