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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Review Article

Drug Design of GLP-1 Receptor Agonists: Importance of In Silico Methods

Author(s): Smriti Sharma and Vinayak Bhatia*

Volume 27, Issue 8, 2021

Published on: 18 November, 2020

Page: [1015 - 1024] Pages: 10

DOI: 10.2174/1381612826666201118094502

Price: $65

Abstract

Drug design based on degradation-resistant, long-acting Glucagon-like peptide-1 receptor (GLP-1R) agonists for treating type 2 diabetes is attracting a lot of attention. Here, the authors have examined in detail how in silico drug design is aiding in developing novel GLP-1 receptor agonist drugs. Their pharmacotherapy and adverse effects have also been summarized. After the analysis of currently available information on this topic, the authors feel that in silico method is a great auxiliary tool in almost all the experimental studies on GLP-1 receptors and is highly efficient in identifying novel drug molecules that can act as GLP-1 receptor agonists.

Keywords: GLP-1, Type 2 diabetes mellitus (T2DM), GLP-1 receptor agonists, In Silico, CADDD, molecular docking, drug design.

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