Abstract
Background: Bone Tuberculosis of the skull base as well as maxillofacial and oral cavity involvement can rarely and only occur in about 3% of the cases with systemic diseases or in case of pulmonary involvement.
Case Presentation: A 37-year-old patient with fever and swelling in his face and neck referred to our center. After MRI and CT scan, it was revealed that multiple erosions and destructions are seen in the Hard Palate bones, as well as the pre-maxillary process, alveolar ridge, and the floor of maxillary sinus on both sides. In the Ziel Nelson staining, there were 5 Acid-fast bacilli in each field. The patient received standard anti-tuberculosis and clarithromycin therapy. In the follow-up three months later, the patient’s condition improved and MRI showed significant remission. Conclusion: The present case confirms that tuberculosis may occur in patients with skull bone involvement and osteolytic lesions whose early diagnosis and treatment can result in gaining good outcomes.Keywords: Tuberculosis, skull bone, maxillary, osteolytic lesions, destruction, Ziel Nelson staining.
Graphical Abstract
Infectious Disorders - Drug Targets
Title:Multifocal Osteolytic Lesions in Skull Bone with Mycobacterium Tuberculosis: A Case Report
Volume: 21 Issue: 5
Author(s): Milad Mellat-Ardakani, Fereshteh Ghiasvand, Malihe Hassan Nezhad, Faeze Salahshour and SeyedAhmad SeyedAlinaghi*
Affiliation:
- Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical Sciences, Tehran,Iran
Keywords: Tuberculosis, skull bone, maxillary, osteolytic lesions, destruction, Ziel Nelson staining.
Abstract: Background: Bone Tuberculosis of the skull base as well as maxillofacial and oral cavity involvement can rarely and only occur in about 3% of the cases with systemic diseases or in case of pulmonary involvement.
Case Presentation: A 37-year-old patient with fever and swelling in his face and neck referred to our center. After MRI and CT scan, it was revealed that multiple erosions and destructions are seen in the Hard Palate bones, as well as the pre-maxillary process, alveolar ridge, and the floor of maxillary sinus on both sides. In the Ziel Nelson staining, there were 5 Acid-fast bacilli in each field. The patient received standard anti-tuberculosis and clarithromycin therapy. In the follow-up three months later, the patient’s condition improved and MRI showed significant remission. Conclusion: The present case confirms that tuberculosis may occur in patients with skull bone involvement and osteolytic lesions whose early diagnosis and treatment can result in gaining good outcomes.Export Options
About this article
Cite this article as:
Mellat-Ardakani Milad , Ghiasvand Fereshteh , Nezhad Hassan Malihe , Salahshour Faeze and SeyedAlinaghi SeyedAhmad *, Multifocal Osteolytic Lesions in Skull Bone with Mycobacterium Tuberculosis: A Case Report, Infectious Disorders - Drug Targets 2021; 21 (5) : e270421187878 . https://dx.doi.org/10.2174/1871526520999201111200140
DOI https://dx.doi.org/10.2174/1871526520999201111200140 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Adverse Drug Reactions Amongst Adult Patients Admitted in Lagos State University Teaching Hospital Lagos, Nigeria
Current Drug Safety The Mode of Inhibition of Mycobacterium tuberculosis Wild-Type and Isoniazid-Resistant 2-Trans-Enoyl-ACP(CoA) Reductase Enzymes by An Inorganic Complex
Anti-Infective Agents in Medicinal Chemistry Current Status Of Short Synthetic Peptides As Vaccines
Medicinal Chemistry New Insights into Vitamin D and Autophagy in Inflammatory Bowel Diseases
Current Medicinal Chemistry A Glance on the Role of Bacterial Siderophore from the Perspectives of Medical and Biotechnological Approaches
Current Drug Targets Patent Selections:
Recent Patents on Drug Delivery & Formulation Selected Pharmaceutical Excipient Prevent Isoniazid and Rifampicin Induced Hepatotoxicity
Current Drug Metabolism Combined 3D-QSAR and molecular docking study for identification of diverse natural products as potent Pf ENR inhibitors
Current Computer-Aided Drug Design Treasures Hunt in Old Mines: Terminalia chebula-Based Traditional Herbal Medicinal Products
The Natural Products Journal Efficacy, Tolerability and Virological Consequences of Long-Term Use of Unboosted Atazanavir Plus 2 NRTIs in HIV-Infected Patients
Current HIV Research From Bone Marrow Transplantation to Cellular Therapies: Possible Therapeutic Strategies in Managing Autoimmune Disorders
Current Pharmaceutical Design Polymorphisms of Human N-Acetyltransferases and Cancer Risk
Current Drug Metabolism Chitosan Derivatives with Antimicrobial, Antitumour and Antioxidant Activities - a Review
Current Pharmaceutical Design Microbial Interactions in Plants: Perspectives and Applications of Proteomics
Current Protein & Peptide Science Bioisosters of β-Lactams as Anti-Infectives
Current Medicinal Chemistry - Anti-Infective Agents The Last Decade of Carbon Paste Electrodes in DNA Electrochemistry
Current Analytical Chemistry Quinoxaline Derivatives: Novel and Selective Butyrylcholinesterase Inhibitors
Medicinal Chemistry A Concise Overview on Recent Advances in Pharmaceutical Aerosols and their Commercial Applications
Current Materials Science Lipid-based Self-Adjuvanting Vaccines
Current Drug Delivery New Potential Biologically Active Compounds: Synthesis and Characterization of Urea and Thiourea Derivativpes Bearing 1,2,4-oxadiazole Ring
Current Organic Synthesis