Interleukin-10 in Oral Lichen Planus – Review and Meta-Analysis

Farzaneh       Agha-Hosseini; Nima       Rezaei; Mahdieh-Sadat       Moosavi

doi:10.2174/1573395516999201111162844

Abstract

Background: Interleukin 10 (IL-10) is a powerful anti-inflammatory cytokine capable of preventing inflammatory and autoimmune diseases. Oral lichen planus (OLP) is an autoimmune, chronic, inflammatory disease with relapsing nature involving oral mucous membranes. It was prevsiouly assumed that like other autoimmune diseases, IL-10 may have a role in OLP pathogenesis, and many studies focused on that. But there are obvious controversies among IL-10 levels in OLP patients.

Objective: In this review with Meta-Analysis, we attempt to assess IL-10 expression in OLP patients.

Methods: The search was conducted via Pubmed, Ovid, and Google Scholar, to identify articles published up to Jun 2020. A meta-Analysis by Revman 5.3 was conducted based on serum levels of IL-10 in 313 OLPs and 203 controls.

Results: With Meta-Analysis in 313 OLPs and 203 controls, the Mean difference between IL-10 in OLPs and controls was obtained as 0.26 (95% CI: -0.51-1.03), demonstrating no statistically significant difference.

Conclusion: IL-10, in concert with its receptors, has a crucial role in the pathogenesis of various diseases, including inflammatory, infectious, and autoimmune diseases. Both over-expression, as well as IL-10 deficiency, have been described in oral lichen planus. With Meta-Analysis on serum IL-10 levels, it is speculated that no significant relationship exists between IL-10 and OLP pathogenesis. With respect to the importance of cytokines in the autoimmunity process, performing additional studies is of necessity to understand the association of other cytokines with OLP predisposition and its underlying pathological processes.

Keywords: Autoimmunity, oral Lichen planus, interleukin 10, serum, inflammatory disease, chronic.

« Previous Next »

Graphical Abstract

[1] 
Zhu Y, Li J, Bai Y, et al. Hydroxychloroquine decreases the upregulated frequencies of Tregs in patients with oral lichen planus. Clin Oral Investig  2014; 18(8): 1903-11.
[http://dx.doi.org/10.1007/s00784-013-1176-z] [PMID: 24420505] 
[2] 
Agha-Hosseini F, Moslemi E, Mirzaii-Dizgah I. Comparative evaluation of low-level laser and CO laser in treatment of patients with oral lichen planus. Int J Oral Maxillofac Surg  2012; 41(10): 1265-9.
[http://dx.doi.org/10.1016/j.ijom.2012.06.001] [PMID: 22784653] 
[3] 
Bai J, Jiang L, Lin M, Zeng X, Wang Z, Chen Q. Association of polymorphisms in the tumor necrosis factor-α and interleukin-10 genes with oral lichen planus: a study in a chinese cohort with Han ethnicity. J Interferon Cytokine Res  2009; 29(7): 381-8.
[http://dx.doi.org/10.1089/jir.2008.0089] [PMID: 19450147] 
[4] 
Iyer SS, Cheng G. Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease. Critical Reviews™ in Immunology  2012; 32(1)
[http://dx.doi.org/10.1615/CritRevImmunol.v32.i1.30] 
[5] 
Xavier GM, de Sá AR, Guimarães AL, da Silva TA, Gomez RS. Investigation of functional gene polymorphisms interleukin-1β, interleukin-6, interleukin-10 and tumor necrosis factor in individuals with oral lichen planus. J Oral Pathol Med  2007; 36(8): 476-81.
[http://dx.doi.org/10.1111/j.1600-0714.2007.00560.x] [PMID: 17686006] 
[6] 
Payeras MR, Cherubini K, Figueiredo MA, Salum FG. Oral lichen planus: focus on etiopathogenesis. Arch Oral Biol  2013; 58(9): 1057-69.
[http://dx.doi.org/10.1016/j.archoralbio.2013.04.004] [PMID: 23660124] 
[7] 
Juretić M, Cerović R, Belušić-Gobić M, et al. Salivary levels of TNF-α and IL-6 in patients with oral premalignant and malignant lesions. Folia Biol (Praha)  2013; 59(2): 99-102.
[PMID: 23746176] 
[8] 
Agha-Hosseini F, Moosavi MS, Hajifaraj Tabrizi M. Comparison of Oral Lichen Planus and Systemic Lupus Erythematosus in Interleukins Level. Arch Iran Med  2015; 18(10): 703-12.
[PMID: 26443253] 
[9] 
Biočina-Lukenda D, Cekić-Arambasin A, Markeljević J, Buković D. Serum immunoglobulins IgG, IgA and IgM in patients with oral lichen ruber. Coll Antropol  2008; 32(1): 161-3.
[PMID: 18496909] 
[10] 
Lukač J, Brozović S, Vucicević-Boras V, Mravak-Stipetić M, Malenica B, Kusić Z. Serum autoantibodies to desmogleins 1 and 3 in patients with oral lichen planus. Croat Med J  2006; 47(1): 53-8.
[PMID: 16489697] 
[11] 
Jin X, Wang J, Zhu L, et al. Association between -308 G/A polymorphism in TNF-α gene and lichen planus: a meta-analysis. J Dermatol Sci  2012; 68(3): 127-34.
[http://dx.doi.org/10.1016/j.jdermsci.2012.09.003] [PMID: 23021488] 
[12] 
Mozaffari HR, Ramezani M, Mahmoudiahmadabadi M, Omidpanah N, Sadeghi M. Salivary and serum levels of tumor necrosis factor-alpha in oral lichen planus: a systematic review and meta-analysis study. Oral Surg Oral Med Oral Pathol Oral Radiol  2017; 124(3): e183-9.
[http://dx.doi.org/10.1016/j.oooo.2017.06.117] [PMID: 28823317] 
[13] 
Qiu M, Wang J, He P, et al. Association between -1082 A/G polymorphism in IL-10 and oral lichen planus: A meta-analysis. J Dermatol Sci  2017; 85(3): 252-3.
[http://dx.doi.org/10.1016/j.jdermsci.2016.12.018] [PMID: 28094099] 
[14] 
van der Meij EH, van der Waal I. Lack of clinicopathologic correlation in the diagnosis of oral lichen planus based on the presently available diagnostic criteria and suggestions for modifications. J Oral Pathol Med  2003; 32(9): 507-12.
[http://dx.doi.org/10.1034/j.1600-0714.2003.00125.x] [PMID: 12969224] 
[15] 
Dan H, Liu W, Wang J, et al. Elevated IL-10 concentrations in serum and saliva from patients with oral lichen planus. Quintessence Int  2011; 42(2): 157-63.
[PMID: 21359250] 
[16] 
Pekiner FN, Demirel GY, Borahan MO, Özbayrak S. Cytokine profiles in serum of patients with oral lichen planus. Cytokine  2012; 60(3): 701-6.
[http://dx.doi.org/10.1016/j.cyto.2012.08.007] [PMID: 22995209] 
[17] 
Zhou G, Zhang J, Ren XW, Hu JY, Du GF, Xu XY. Increased B7-H1 expression on peripheral blood T cells in oral lichen planus correlated with disease severity. J Clin Immunol  2012; 32(4): 794-801.
[http://dx.doi.org/10.1007/s10875-012-9683-2] [PMID: 22430646] 
[18] 
Zhou L, Cao T, Wang Y, et al. Frequently Increased but Functionally Impaired CD4+CD25+ Regulatory T Cells in Patients with Oral Lichen Planus. Inflammation  2016; 39(3): 1205-15.
[http://dx.doi.org/10.1007/s10753-016-0356-9] [PMID: 27106476] 
[19] 
Femiano F, Scully C. Functions of the cytokines in relation oral lichen planus-hepatitis C. Med Oral Patol Oral Cir Bucal  2005; 10(Suppl. 1): E40-4.
[PMID: 15800466] 
[20] 
Kalogerakou F, Albanidou-Farmaki E, Markopoulos AK, Antoniades DZ. Detection of T cells secreting type 1 and type 2 cytokines in the peripheral blood of patients with oral lichen planus. Hippokratia  2008; 12(4): 230-5.
[PMID: 19158967] 
[21] 
Simark-Mattsson C, Bergenholtz G, Jontell M, et al. Distribution of interleukin-2, -4, -10, tumour necrosis factor-α and transforming growth factor-β mRNAs in oral lichen planus. Arch Oral Biol  1999; 44(6): 499-507.
[http://dx.doi.org/10.1016/S0003-9969(99)00013-8] [PMID: 10401528] 
[22] 
Mittal SK, Roche PA. Suppression of antigen presentation by IL-10. Curr Opin Immunol  2015; 34: 22-7.
[http://dx.doi.org/10.1016/j.coi.2014.12.009] [PMID: 25597442] 
[23] 
Llorente L, Richaud-Patin Y. The role of interleukin-10 in systemic lupus erythematosus. J Autoimmun  2003; 20(4): 287-9.
[http://dx.doi.org/10.1016/S0896-8411(03)00043-X] [PMID: 12791314] 
[24] 
Wang B, Zhu J-M, Fan Y-G, et al. Association of the -1082G/A polymorphism in the interleukin-10 gene with systemic lupus erythematosus: a meta-analysis. Gene  2013; 519(2): 209-16.
[http://dx.doi.org/10.1016/j.gene.2013.01.026] [PMID: 23415626] 
[25] 
Al-Mohaya MA, Al-Harthi F, Arfin M, Al-Asmari A. TNF-α, TNF-β and IL-10 gene polymorphism and association with oral lichen planus risk in Saudi patients. J Appl Oral Sci  2015; 23(3): 295-301.
[http://dx.doi.org/10.1590/1678-775720150075] [PMID: 26221924] 
[26] 
King A, Balaji S, Le LD, Crombleholme TM, Keswani SG. Regenerative Wound Healing: The Role of Interleukin-10. Adv Wound Care (New Rochelle)  2014; 3(4): 315-23.
[http://dx.doi.org/10.1089/wound.2013.0461] [PMID: 24757588] 
[27] 
Georgakopoulou EA, Achtari MD, Achtaris M, Foukas PG, Kotsinas A. Oral lichen planus as a preneoplastic inflammatory model. J BioMed BioTechnol  2012; 2012: 759626.
[http://dx.doi.org/10.1155/2012/759626] 
[28] 
Czerninski R, Basile JR, Kartin-Gabay T, Laviv A, Barak V. Cytokines and tumor markers in potentially malignant disorders and oral squamous cell carcinoma: a pilot study. Oral Dis  2014; 20(5): 477-81.
[http://dx.doi.org/10.1111/odi.12160] [PMID: 23859102] 
[29] 
HJ H. Role of cytokine gene (interferon-g, transforminggrowth factor-b1, tumor necrosis factor-a, interleukin-6, and interleukin-10) polymorphismsin the risk of oral precancerous lesions inTaiwanese. Kaohsiung J Med Sci  2014; 30: 8.

Rights & Permissions Print Cite

Article Metrics

9

1

DOI https://dx.doi.org/10.2174/1573395516999201111162844	Print ISSN 1573-3955
Publisher Name Bentham Science Publisher	Online ISSN 1875-631X

Current Immunology Reviews (Discontinued)

Interleukin-10 in Oral Lichen Planus – Review and Meta-Analysis

Abstract Play Pause

Graphical Abstract

Related Articles

Abstract