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Current Alzheimer Research

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Review Article

Research Progress on circRNA in Nervous System Diseases

Author(s): Nana Ma, Wei Zhang* and Jun Wan*

Volume 17, Issue 8, 2020

Page: [687 - 697] Pages: 11

DOI: 10.2174/1567205017666201111114928

Price: $65

Abstract

Circular RNAs (circRNAs) are a kind of non-coding RNA molecule with highly stable circular structures. CircRNAs are primarily composed of exons and/or introns. Recently, a lot of exciting studies showed that circRNA played an essential role in the development of nervous system diseases. Here, classification, characteristics, biogenesis, and the association of circRNA dysregulation with nervous system diseases, such as Alzheimer’s disease, are summarized. The review not only contributes to a better understanding of circRNAs, but also provides new research directions toward the diagnosis, treatment, and prevention of nervous system diseases.

Keywords: Circular RNA, non-coding RNA, nervous system, disease, Alzheimer's disease, Parkinson disease.

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