Serum Pro-oxidant-antioxidant Balance in Subjects with Type 2 Diabetes Mellitus

Title:Serum Pro-oxidant-antioxidant Balance in Subjects with Type 2 Diabetes Mellitus

Volume: 24 Issue: 9

Author(s): Mahsa Ahmadnezhad*, Hamideh Ghazizadeh*, Moniba Bijari*, Mohammad Reza Oladi*, Habibollah Esmaily, Seyed Javad Hoseini, Elham Barati, Samaneh Silakhori, Maryam Mohammadi-Bajgiran, Hafezeh Davari, Mohammad Reza Parizadeh, Naghme Mokhber, Payam Sharifan, Seyed Rafie Aref-Hosseini, Gordon A Ferns, Mohsen Moohebati and Majid Ghayour-Mobarhan

Affiliation:

• Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad,Iran

• Student Research Committee, Mashhad University of Medical Sciences, Mashhad,Iran

• Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad,Iran

• International UNESCO Center for Health- Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad,Iran

Keywords: Pro-oxidant-Antioxidant balance, Type 2 diabetes mellitus, MASHAD cohort study, oxidative stress, inflammation.

Abstract: Aim and Objective: Diabetes mellitus is associated with inflammation and increased oxidative stress. In the current study, we aimed to investigate the relationship between type 2 diabetes mellitus (T2DM) and serum pro-oxidant-antioxidant balance (PAB) in a large populationbased study.

Methods: In this cross-sectional study, 7888 individuals were recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorders (MASHAD) cohort study. Participants were divided into three groups based on their serum PAB values (levels < 36.4, 36.4-82.6 and > 82.6 HK). Serum PAB values were measured using a colorimetric method and enzyme-linked immune sorbent assay (ELISA).

Results: Serum PAB in subjects with and without diabetes was reported 76.85 ± 61.07 HK and 69.51 ± 55.50 HK. In subjects with a serum PAB > 82.6 HK the risk of T2DM was 1.2 fold higher in comparison to subjects with a serum PAB < 36.4 HK (OR: 1.26, 95% CI: 1.09 – 1.47, P-value: 0.002). This association remained significant after adjustment for confounding factors in multivariable analysis (OR: 1.19, 95% CI: 1.02 – 1.38, P-value: 0.027).

Conclusion: Increased pro-oxidant levels may be a major complication of T2DM in our study subjects and PAB could be an indicator of higher oxidative stress in T2DM patients from northeastern Iran.

Cite this article as:

Ahmadnezhad Mahsa *, Ghazizadeh Hamideh *, Bijari Moniba *, Oladi Reza Mohammad *, Esmaily Habibollah , Hoseini Javad Seyed , Barati Elham , Silakhori Samaneh , Mohammadi-Bajgiran Maryam , Davari Hafezeh , Parizadeh Reza Mohammad , Mokhber Naghme , Sharifan Payam , Aref-Hosseini Rafie Seyed , Ferns A Gordon , Moohebati Mohsen and Ghayour-Mobarhan Majid , Serum Pro-oxidant-antioxidant Balance in Subjects with Type 2 Diabetes Mellitus, Combinatorial Chemistry & High Throughput Screening 2021; 24 (9) . https://dx.doi.org/10.2174/1386207323999201103203153

DOI https://dx.doi.org/10.2174/1386207323999201103203153	Print ISSN 1386-2073
Publisher Name Bentham Science Publisher	Online ISSN 1875-5402